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Paper · 35657690

Cross Talk Between Insulin and Glucagon Receptor Signaling in the Hepatocyte.

Habegger KM. Diabetes, 2022. Cited by 23 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Cross Talk Between Insulin and Glucagon Receptor Signaling in the Hepatocyte. Papers, record 35657690. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/35657690

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Cross Talk Between Insulin and Glucagon Receptor Signaling in the Hepatocyte.
PubMed
Journal
Diabetes
PubMed
Year
2022
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Review
PubMed
Citations, by iCite
23
iCite
Relative citation ratio, by iCite
1.83
iCite
Revised in PubMed
2026-09-28
PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Habegger KMKirk Mhttps://orcid.org/0000-0002-0342-5480

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
GlucagonMajor topic
InsulinMajor topic
Animals
Blood Glucose
Glucose
Hepatocytes
Insulin, Regular, Human
Liver
Receptors, Glucagon

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P30 DK056336NIDDK NIH HHSUnited StatesP30DK056336PubMed and NIHNIH RePORTER
R01 DK112934NIDDK NIH HHSUnited StatesR01DK112934PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References117

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
110,816,439Perivenous localization of insulin receptor protein in rat liver, and regulation of its expression by glucose and oxygen in hepatocyte cultures.Biochem J2000https://conductscience.org/library/papers/10816439PubMed
215,047,619Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.Diabetes2004https://conductscience.org/library/papers/15047619PubMed
317,409,288The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications.Endocr Rev2007https://conductscience.org/library/papers/17409288PubMed
41,689,116Mechanism of sympathetic neural regulation of insulin, somatostatin, and glucagon secretion.Am J Physiol1990https://conductscience.org/library/papers/1689116PubMed
534,280,055Altered islet prohormone processing: a cause or consequence of diabetes?Physiol Rev2022https://conductscience.org/library/papers/34280055PubMed
630,203,123Single and multiple ascending-dose study of glucagon-receptor antagonist RN909 in type 2 diabetes: a phase 1, randomized, double-blind, placebo-controlled trial.Endocrine2018https://conductscience.org/library/papers/30203123PubMed
79,133,545Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas.Diabetes1997https://conductscience.org/library/papers/9133545PubMed
823,391,236Brain control of insulin and glucagon secretion.Endocrinol Metab Clin North Am2013https://conductscience.org/library/papers/23391236PubMed
97,590,348Cloning and sequence analysis of the murine glucagon receptor-encoding gene.Gene1995https://conductscience.org/library/papers/7590348PubMed
1022,214,853Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover.J Clin Invest2012https://conductscience.org/library/papers/22214853PubMed

1 to 10 of 117

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Cited by14

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 23 citations.

PMIDTitleJournalYearIn PapersSource
42,798,578Metabolomics profile in diabetes and blood glucose regulation: a systematic review.Front Nutr2026https://conductscience.org/library/papers/42798578PubMed
42,541,251Lipophagy: A key regulator in oxidative stress and metabolic disorders.Genes Dis2026https://conductscience.org/library/papers/42541251PubMed
41,659,206Three-dimensional interactive network: Mitochondrial-metabolic-calcium homeostasis driving Alzheimer's disease.Genes Dis2026https://conductscience.org/library/papers/41659206PubMed
41,635,536Synergistic therapeutic strategies for metabolic dysfunction-associated steatohepatitis and type 2 diabetes mellitus: molecular insights and clinical advances.Front Endocrinol (Lausanne)2025https://conductscience.org/library/papers/41635536PubMed
41,564,388Hepatocyte-hepatic stellate cell interactions in liver fibrosis: Mechanisms and therapeutic implications.Hepatol Commun2026https://conductscience.org/library/papers/41564388PubMed
41,513,899Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences.Nat Rev Endocrinol2026https://conductscience.org/library/papers/41513899PubMed
41,381,083Feasibility and Preliminary Impacts of a Diabetes Education Chatbot Simulation on Glycemic Targets, Loneliness, and Health Beliefs in Indonesia: An Explanatory Mixed-methods Study.J Prev Med Public Health2026https://conductscience.org/library/papers/41381083PubMed
40,994,783Effects of dietary n-6/n-3 PUFA ratio on growth performance and lipid metabolism in nursery pigs.Front Vet Sci2025https://conductscience.org/library/papers/40994783PubMed
40,969,875Ultrastable Insulin-Glucagon Fusion Protein Exploits an Endogenous Hepatic Switch to Mitigate Hypoglycemic Risk.ACS Pharmacol Transl Sci2025https://conductscience.org/library/papers/40969875PubMed
40,399,267GLP-1R/GCGR dual agonism dissipates hepatic steatosis to restore insulin sensitivity and rescue pancreatic β-cell function in obese male mice.Nat Commun2025https://conductscience.org/library/papers/40399267PubMed

1 to 10 of 14

See all 14 cited by

Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
GCG2,641PubTator's text mininghttps://conductscience.org/library/genes/2641NCBI Gene
GCGR2,642PubTator's text mininghttps://conductscience.org/library/genes/2642NCBI Gene
GH12,688PubTator's text mininghttps://conductscience.org/library/genes/2688NCBI Gene
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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