ConductScience.org, home
Papers
API referenceFor AI assistants

Paper · 36735378

The importance of cache domains in α2δ proteins and the basis for their gabapentinoid selectivity.

Page KM and 4 others. Channels (Austin), 2023. Cited by 10 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Download JSON
Cite this record

ConductScience Library. The importance of cache domains in α2δ proteins and the basis for their gabapentinoid selectivity. Papers, record 36735378. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/36735378

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The importance of cache domains in α2δ proteins and the basis for their gabapentinoid selectivity.
PubMed
Journal
Channels (Austin)
PubMed
Year
2023
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural
PubMed
Citations, by iCite
10
iCite
Relative citation ratio, by iCite
1.02
iCite
Revised in PubMed
2023-03-23
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Page KMKaren M
2Gumerov VMVadim M
3Dahimene SShehrazade
4Zhulin IBIgor B
5Dolphin ACAnnette Chttps://orcid.org/0000-0003-4626-4856

Source PubMed

Topics4

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Calcium ChannelsMajor topic
AminesMajor topic
Gabapentin
Cell Membrane

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R35 GM131760NIGMS NIH HHSUnited StatesR35GM131760PubMed and NIHNIH RePORTER
098360/Z/12/ZWellcome TrustUnited KingdomPubMedPubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References84

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
12,168,391Subunits of purified calcium channels. Alpha 2 and delta are encoded by the same gene.J Biol Chem1990https://conductscience.org/library/papers/2168391PubMed
211,130,987Genomic organization of the mouse and human alpha2delta2 voltage-dependent calcium channel subunit genes.Mamm Genome2000https://conductscience.org/library/papers/11130987PubMed
329,391,435The activity of the C4-dicarboxylic acid chemoreceptor of Pseudomonas aeruginosa is controlled by chemoattractants and antagonists.Sci Rep2018https://conductscience.org/library/papers/29391435PubMed
420,861,389The alpha2delta ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit alpha2delta-2.J Neurosci2010https://conductscience.org/library/papers/20861389PubMed
518,690,052Time course and specificity of the pharmacological disruption of the trafficking of voltage-gated calcium channels by gabapentin.Channels (Austin)2008https://conductscience.org/library/papers/18690052PubMed
630,683,685Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.J Neurosci2019https://conductscience.org/library/papers/30683685PubMed
717,033,974Mutation in the auxiliary calcium-channel subunit CACNA2D4 causes autosomal recessive cone dystrophy.Am J Hum Genet2006https://conductscience.org/library/papers/17033974PubMed
816,061,813The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels.Proc Natl Acad Sci U S A2005https://conductscience.org/library/papers/16061813PubMed
921,558,437Anxiolytic-like activity of pregabalin in the Vogel conflict test in α2δ-1 (R217A) and α2δ-2 (R279A) mouse mutants.J Pharmacol Exp Ther2011https://conductscience.org/library/papers/21558437PubMed
109,880,589Molecular diversity of the calcium channel alpha2delta subunit.J Neurosci1999https://conductscience.org/library/papers/9880589PubMed

1 to 10 of 84

See all 84 references

Cited by9

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 10 citations.

PMIDTitleJournalYearIn PapersSource
42,457,853Synaptic Ca2+ channels and neurexins are linked through direct and indirect binding complexes.Sci Rep2026https://conductscience.org/library/papers/42457853PubMed
40,971,110Calcium Channel α2δ Ligands Mirogabalin, Pregabalin, and Gabapentin: Advancements in Diabetic Peripheral Neuropathic Pain Therapeutics.Pain Ther2025https://conductscience.org/library/papers/40971110PubMed
40,664,238Biochemistry and physiology of voltage-gated calcium channel trafficking: a target for gabapentinoid drugs.Open Biol2025https://conductscience.org/library/papers/40664238PubMed
40,367,942Presynaptic α2δs specify synaptic gain, not synaptogenesis, in the mammalian brain.Neuron2025https://conductscience.org/library/papers/40367942PubMed
39,136,907The Voltage-Gated Calcium Channel α2δ Subunit in Neuropathic Pain.Mol Neurobiol2025https://conductscience.org/library/papers/39136907PubMed
39,079,659Evaluation of Pregabalin bioadhesive multilayered microemulsion IOP-lowering eye drops.J Control Release2024https://conductscience.org/library/papers/39079659PubMed
37,647,406Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor.Sci Adv2023https://conductscience.org/library/papers/37647406PubMed
37,286,823Fighting pain: the structure of gabapentin and its binding site in the Cavα2δ subunit.Nat Struct Mol Biol2023https://conductscience.org/library/papers/37286823PubMed
36,973,510Structural basis for CaVα2δ:gabapentin binding.Nat Struct Mol Biol2023https://conductscience.org/library/papers/36973510PubMed

Genes10

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CACHD157,685PubTator's text mininghttps://conductscience.org/library/genes/57685NCBI Gene
CACNA1S779PubTator's text mininghttps://conductscience.org/library/genes/779NCBI Gene
CACNA2D1781PubTator's text mininghttps://conductscience.org/library/genes/781NCBI Gene
CACNA2D29,254PubTator's text mininghttps://conductscience.org/library/genes/9254NCBI Gene
CACNA2D355,799PubTator's text mininghttps://conductscience.org/library/genes/55799NCBI Gene
CAV1857PubTator's text mininghttps://conductscience.org/library/genes/857NCBI Gene
CAV2858PubTator's text mininghttps://conductscience.org/library/genes/858NCBI Gene
GPHA2170,589PubTator's text mininghttps://conductscience.org/library/genes/170589NCBI Gene
NR2E310,002PubTator's text mininghttps://conductscience.org/library/genes/10002NCBI Gene
RAB11A8,766PubTator's text mininghttps://conductscience.org/library/genes/8766NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/36735378

GET https://conductscience.org/api/papers/v1/36735378/references?page=2

API referenceFor AI assistants