Paper · 38510491
miR-539-5p targets BMP2 to regulate Treg activation in B-cell acute lymphoblastic leukemia through TGF-β/Smads/MAPK.
Dai Q and 9 others. Exp Biol Med (Maywood), 2024. Cited by 4 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. miR-539-5p targets BMP2 to regulate Treg activation in B-cell acute lymphoblastic leukemia through TGF-β/Smads/MAPK. Papers, record 38510491. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/38510491
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- miR-539-5p targets BMP2 to regulate Treg activation in B-cell acute lymphoblastic leukemia through TGF-β/Smads/MAPK.
- PubMed
Topics8
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| MicroRNAs | Major topic |
| Precursor Cell Lymphoblastic Leukemia-Lymphoma | Major topic |
| Humans | |
| Transforming Growth Factor beta | |
| Transforming Growth Factor beta1 | |
| T-Lymphocytes, Regulatory | |
| Cell Proliferation | |
| Bone Morphogenetic Protein 2 |
Source PubMed
Grants0
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
None in this release.
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References55
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 30,169,285 | Global efforts toward the cure of childhood acute lymphoblastic leukaemia. | Lancet Child Adolesc Health | 2018 | https://conductscience.org/library/papers/30169285 | PubMed |
| 2 | 28,627,521 | Regulatory T cells: Subset-specific suppression. | Nat Rev Immunol | 2017 | https://conductscience.org/library/papers/28627521 | PubMed |
| 3 | 31,102,428 | Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target? | Cancer Sci | 2019 | https://conductscience.org/library/papers/31102428 | PubMed |
| 4 | 33,973,623 | miRNA interplay: mechanisms and consequences in cancer. | Dis Model Mech | 2021 | https://conductscience.org/library/papers/33973623 | PubMed |
| 5 | 26,465,987 | Acute Lymphoblastic Leukemia in Children. | N Engl J Med | 2015 | https://conductscience.org/library/papers/26465987 | PubMed |
| 6 | 31,833,074 | The role of microRNAs in acute lymphoblastic leukaemia: From biology to applications. | Cell Biochem Funct | 2020 | https://conductscience.org/library/papers/31833074 | PubMed |
| 7 | 25,968,569 | CD4+ and CD8+ T cells have opposing roles in breast cancer progression and outcome. | Oncotarget | 2015 | https://conductscience.org/library/papers/25968569 | PubMed |
| 8 | 26,110,906 | The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis. | PLoS One | 2015 | https://conductscience.org/library/papers/26110906 | PubMed |
| 9 | 31,257,581 | Targeting Treg cells in cancer immunotherapy. | Eur J Immunol | 2019 | https://conductscience.org/library/papers/31257581 | PubMed |
| 10 | 14,534,577 | Smad-dependent and Smad-independent pathways in TGF-beta family signalling. | Nature | 2003 | https://conductscience.org/library/papers/14534577 | PubMed |
1 to 10 of 55
See all 55 referencesCited by3
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 4 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 41,751,802 | Transcriptomic Profiling of MicroRNA and Non-Coding RNA from Whole Blood of African Americans with MASLD. | Int J Mol Sci | 2026 | https://conductscience.org/library/papers/41751802 | PubMed |
| 40,955,148 | miR-539-5p Regulates Irritable Bowel Syndrome Pathological Processes by Targeting KDM6A. | Turk J Gastroenterol | 2025 | https://conductscience.org/library/papers/40955148 | PubMed |
| 39,125,380 | Apoptosis and Inflammation Involved with Fluoride-Induced Bone Injuries. | Nutrients | 2024 | https://conductscience.org/library/papers/39125380 | PubMed |
Genes6
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| BMP2 | 650 | PubTator's text mining | https://conductscience.org/library/genes/650 | NCBI Gene |
| CD4 | 920 | PubTator's text mining | https://conductscience.org/library/genes/920 | NCBI Gene |
| IL2RA | 3,559 | PubTator's text mining | https://conductscience.org/library/genes/3559 | NCBI Gene |
| SMAD1 | 4,086 | PubTator's text mining | https://conductscience.org/library/genes/4086 | NCBI Gene |
| SMAD2 | 4,087 | PubTator's text mining | https://conductscience.org/library/genes/4087 | NCBI Gene |
| TGFB1 | 7,040 | PubTator's text mining | https://conductscience.org/library/genes/7040 | NCBI Gene |
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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