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Paper · 39475504

Nicotinic Signaling Stimulates Glucagon Secretion in Mouse and Human Pancreatic α-Cells.

Hamilton A and 9 others. Diabetes, 2025. Cited by 6 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Nicotinic Signaling Stimulates Glucagon Secretion in Mouse and Human Pancreatic α-Cells. Papers, record 39475504. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39475504

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Nicotinic Signaling Stimulates Glucagon Secretion in Mouse and Human Pancreatic α-Cells.
PubMed
Journal
Diabetes
PubMed
Year
2025
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
6
iCite
Relative citation ratio, by iCite
1.77, provisional
iCite
Revised in PubMed
2026-07-21
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Hamilton AAlexander
2Zhang QQuan
3Gao RRui
4Hill TGThomas G
5Salehi AAlbert
6Knudsen JGJakob Ghttps://orcid.org/0000-0001-7237-8457
7Draper MBMatthew B
8Johnson PRVPaul R V
9Rorsman PPatrik
10Tarasov AIAndrei Ihttps://orcid.org/0000-0002-8883-176X

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Glucagon-Secreting CellsMajor topic
GlucagonMajor topic
NicotineMajor topic
Signal TransductionMajor topic
Animals
Mice
Humans
Insulin-Secreting Cells
Receptors, Nicotinic
Calcium
Male
Mice, Inbred C57BL

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
Fellowship, AITOxford Biomedical Research CouncilPubMed
PhD Studentship, AHDiabetes UKUnited KingdomPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References49

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
17,908,511Splanchnic neural regulation of somatostatin secretion in the isolated perfused human pancreas.Ann Surg1994https://conductscience.org/library/papers/7908511PubMed
2669,104Pancreatic polypeptide, glucagon and insulin secretion from the isolated perfused canine pancreas.Diabetologia1978https://conductscience.org/library/papers/669104PubMed
332,446,876Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet.Mol Metab2020https://conductscience.org/library/papers/32446876PubMed
419,434,055Impact of cigarette smoking in type 2 diabetes development.Acta Pharmacol Sin2009https://conductscience.org/library/papers/19434055PubMed
58,243,825Mechanism of awareness of hypoglycemia. Perception of neurogenic (predominantly cholinergic) rather than neuroglycopenic symptoms.Diabetes1993https://conductscience.org/library/papers/8243825PubMed
62,653,928Increased beta-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance.Diabetes1989https://conductscience.org/library/papers/2653928PubMed
73,288,530Automated method for isolation of human pancreatic islets.Diabetes1988https://conductscience.org/library/papers/3288530PubMed
8171,380The number of transmitter molecules in a quantum: an estimate from iontophoretic application of acetylcholine at the neuromuscular synapse.J Physiol1975https://conductscience.org/library/papers/171380PubMed
99,753,299Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects.Diabetes1998https://conductscience.org/library/papers/9753299PubMed
1027,390,011Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.Diabetologia2016https://conductscience.org/library/papers/27390011PubMed

1 to 10 of 49

See all 49 references

Cited by6

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 6 citations.

PMIDTitleJournalYearIn PapersSource
42,287,584Association between electronic cigarette use and prediabetes, diabetes, and insulin resistance: a systematic review and meta-analysis.Intern Emerg Med2026https://conductscience.org/library/papers/42287584PubMed
42,155,411Partial restoration of counterregulatory circulating glucagon by dapagliflozin and low-dose glibenclamide in men with type 1 diabetes: in vitro studies and randomised clinical crossover trial.EBioMedicine2026https://conductscience.org/library/papers/42155411PubMed
41,418,583ER calcium stores contribute to glucose-induced Ca2+ waves and intercellular connectivity in mouse pancreatic islets.Cell Calcium2026https://conductscience.org/library/papers/41418583PubMed
41,206,016Glucagon, the Alpha Cell, and Potential Targets for Diabetes Treatment.Endocrinology2025https://conductscience.org/library/papers/41206016PubMed
40,919,135Pancreatic Islet Cell Hormones: Secretion, Function, and Diabetes Therapy.MedComm (2020)2025https://conductscience.org/library/papers/40919135PubMed
40,364,147Recent Advances in Ionic Mechanisms in Pituitary Cells: Implications for Electrophysiological and Electropharmacological Research.J Clin Med2025https://conductscience.org/library/papers/40364147PubMed

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
GCG2,641PubTator's text mininghttps://conductscience.org/library/genes/2641NCBI Gene
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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