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Paper · 39562829

KBTBD2 controls bone development by regulating IGF-1 signaling during osteoblast differentiation.

Xun Y and 5 others. Cell Death Differ, 2025. Cited by 8 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. KBTBD2 controls bone development by regulating IGF-1 signaling during osteoblast differentiation. Papers, record 39562829. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39562829

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
KBTBD2 controls bone development by regulating IGF-1 signaling during osteoblast differentiation.
PubMed
Journal
Cell Death Differ
PubMed
Year
2025
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural
PubMed
Citations, by iCite
8
iCite
Relative citation ratio, by iCite
2.29, provisional
iCite
Revised in PubMed
2026-09-16
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Xun YYu
2Jiang YYiao
3Khalid AAysha
4Tian ZZeru
5Rios JJonathanhttps://orcid.org/0000-0002-0969-2184
6Zhang ZZhaohttps://orcid.org/0000-0001-9345-3663

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Insulin-Like Growth Factor IMajor topic
OsteoblastsMajor topic
Cell DifferentiationMajor topic
Bone DevelopmentMajor topic
Animals
Signal Transduction
Mice
Osteogenesis
Humans
Proto-Oncogene Proteins c-akt
Mice, Knockout
Class Ia Phosphatidylinositol 3-Kinase

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
R21 HD117154NICHD NIH HHSUnited StatesR21HD117154PubMed and NIH
R21HD117154U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)R21HD117154PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References44

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
128,198,415Quick and inexpensive paraffin-embedding method for dynamic bone formation analyses.Sci Rep2017https://conductscience.org/library/papers/28198415PubMed
219,246,619The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments.Clin Chem2009https://conductscience.org/library/papers/19246619PubMed
327,708,159Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.Proc Natl Acad Sci U S A2016https://conductscience.org/library/papers/27708159PubMed
426,974,159PI3-kinase mutation linked to insulin and growth factor resistance in vivo.J Clin Invest2016https://conductscience.org/library/papers/26974159PubMed
58,762,647[Histomorphometric analysis of the bone tissue in patients with non-insulin-dependent diabetes (DMNID)].Rev Hosp Clin Fac Med Sao Paulo1996https://conductscience.org/library/papers/8762647PubMed
624,077,964Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice.Dis Model Mech2013https://conductscience.org/library/papers/24077964PubMed
721,907,838Genetic mouse models for bone studies--strengths and limitations.Bone2011https://conductscience.org/library/papers/21907838PubMed
88,669,449SHORT syndrome: a new case with probable autosomal dominant inheritance.Am J Med Genet1996https://conductscience.org/library/papers/8669449PubMed
930,041,403Neuroglobin Regulates Wnt/β-Catenin and NFκB Signaling Pathway through Dvl1.Int J Mol Sci2018https://conductscience.org/library/papers/30041403PubMed
1022,729,283Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells.Nat Med2012https://conductscience.org/library/papers/22729283PubMed

1 to 10 of 44

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Cited by6

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 8 citations.

PMIDTitleJournalYearIn PapersSource
42,494,755Ultrasonic-driven force-electric nanodomains orchestrate lysosome-to-mitochondria functional cascade to accelerate bone regeneration.Bioact Mater2026https://conductscience.org/library/papers/42494755PubMed
42,286,555Type 2 diabetes mellitus impairs tooth supraeruption by disrupting periapical alveolar bone remodeling.BMC Oral Health2026https://conductscience.org/library/papers/42286555PubMed
42,202,563Combined in ovo and post-hatch choline supplementation enhances growth and muscle development in goslings.Poult Sci2026https://conductscience.org/library/papers/42202563PubMed
42,026,367The liver-bone axis: an emerging player in disease pathogenesis and therapeutic intervention.Sci China Life Sci2026https://conductscience.org/library/papers/42026367PubMed
42,020,734The evolutionary history and unique genetic diversity of Indigenous Americans.Nature2026https://conductscience.org/library/papers/42020734PubMed
41,500,998GIPC2 regulation of the PKM2/SREBP1 signaling axis controls adipogenic differentiation of mesenchymal stem cells.Cell Death Dis2026https://conductscience.org/library/papers/41500998PubMed

Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
IGF13,479PubTator's text mininghttps://conductscience.org/library/genes/3479NCBI Gene
KBTBD225,948PubTator's text mininghttps://conductscience.org/library/genes/25948NCBI Gene
PIK3R15,295PubTator's text mininghttps://conductscience.org/library/genes/5295NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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