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Paper · 39722698

sTREM2 cerebrospinal fluid levels are a potential biomarker in amyotrophic lateral sclerosis and associate with UMN burden.

Jiao L and 5 others. Front Neurol, 2024. Cited by 15 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. sTREM2 cerebrospinal fluid levels are a potential biomarker in amyotrophic lateral sclerosis and associate with UMN burden. Papers, record 39722698. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39722698

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
sTREM2 cerebrospinal fluid levels are a potential biomarker in amyotrophic lateral sclerosis and associate with UMN burden.
PubMed
Journal
Front Neurol
PubMed
Year
2024
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
15
iCite
Relative citation ratio, by iCite
2.16, provisional
iCite
Revised in PubMed
2025-01-04
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Jiao LLin
2Yang JJing
3Wang WWenjing
4Liu XXiangyi
5Fu YYu
6Fan DDongsheng

Source PubMed

Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References33

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
136,116,464Amyotrophic lateral sclerosis.Lancet2022https://conductscience.org/library/papers/36116464PubMed
227,995,062Magnetic susceptibility in the deep layers of the primary motor cortex in Amyotrophic Lateral Sclerosis.Neuroimage Clin2016https://conductscience.org/library/papers/27995062PubMed
338,647,181Motor band sign is specific for amyotrophic lateral sclerosis and corresponds to motor symptoms.Ann Clin Transl Neurol2024https://conductscience.org/library/papers/38647181PubMed
435,806,270Iron, Neuroinflammation and Neurodegeneration.Int J Mol Sci2022https://conductscience.org/library/papers/35806270PubMed
536,408,515The association between cerebrospinal ferritin and soluble triggering receptor expressed on myeloid cells 2 along Alzheimer's continuum.Front Neurol2022https://conductscience.org/library/papers/36408515PubMed
616,434,671Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS.Neurology2006https://conductscience.org/library/papers/16434671PubMed
711,464,847El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis.Amyotroph Lateral Scler Other Motor Neuron Disord2000https://conductscience.org/library/papers/11464847PubMed
828,651,542Evidence for an early innate immune response in the motor cortex of ALS.J Neuroinflammation2017https://conductscience.org/library/papers/28651542PubMed
926,941,262sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers.EMBO Mol Med2016https://conductscience.org/library/papers/26941262PubMed
1036,681,358Profiling TREM2 expression in amyotrophic lateral sclerosis.Brain Behav Immun2023https://conductscience.org/library/papers/36681358PubMed

1 to 10 of 33

See all 33 references

Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 15 citations.

PMIDTitleJournalYearIn PapersSource
42,865,133Context-dependent TREM2 signalling in myeloid cells: Molecular mechanisms and immunotherapeutic divergence in neurodegeneration and cancer.Clin Transl Med2026https://conductscience.org/library/papers/42865133PubMed
42,694,654TREM2 as a central hub of neuroimmune-metabolic crosstalk in central nervous system disorders: from microglial biology to therapeutic targeting.Front Immunol2026https://conductscience.org/library/papers/42694654PubMed
42,582,058Revisiting TREM2: from multi-omics signaling networks to clinical translation.Front Immunol2026https://conductscience.org/library/papers/42582058PubMed
42,458,498TREM2 in neurodegenerative diseases and acute neurological injuries: mechanisms to targeted therapies.Cell Commun Signal2026https://conductscience.org/library/papers/42458498PubMed
42,382,745The TREM2 paradox in fibrosis: a unified mechanism for opposite outcomes across organs.Front Immunol2026https://conductscience.org/library/papers/42382745PubMed
42,359,357Innate immune crosstalk in ALS/FTD pathogenesis.Cell Insight2026https://conductscience.org/library/papers/42359357PubMed
41,533,211TREM2-mediated Crosstalk in ALS: Microglial Fate Transition, Protein Aggregate Clearance, and Peripheral Nerve Repair.Neurosci Bull2026https://conductscience.org/library/papers/41533211PubMed
41,530,159Parkinson's disease: spatiotemporal regulation and therapeutic prospects of TREM2-mediated microglial responses.NPJ Parkinsons Dis2026https://conductscience.org/library/papers/41530159PubMed
41,449,430Role of TREM2 in neuroinflammation regulation: mechanisms, disease associations, and therapeutic translation advances.J Transl Med2025https://conductscience.org/library/papers/41449430PubMed
41,096,792The Biomarker Profile of Alzheimer's Disease for Disease-Modifying Treatment Eligibility: Questions and Debates.Int J Mol Sci2025https://conductscience.org/library/papers/41096792PubMed

1 to 10 of 13

See all 13 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
NEFL4,747PubTator's text mininghttps://conductscience.org/library/genes/4747

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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