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Paper · 40257546

Targeting IL-13 and IL-4 in Asthma: Therapeutic Implications on Airway Remodeling in Severe Asthma.

Sahnoon L and 4 others. Clin Rev Allergy Immunol, 2025. Cited by 63 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Targeting IL-13 and IL-4 in Asthma: Therapeutic Implications on Airway Remodeling in Severe Asthma. Papers, record 40257546. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/40257546

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Targeting IL-13 and IL-4 in Asthma: Therapeutic Implications on Airway Remodeling in Severe Asthma.
PubMed
Journal
Clin Rev Allergy Immunol
PubMed
Year
2025
PubMed
Publication types
Journal Article, Review
PubMed
Citations, by iCite
63
iCite
Relative citation ratio, by iCite
18.29, provisional
iCite
Revised in PubMed
2025-04-24
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Sahnoon LLina
2Bajbouj KKhuloud
3Mahboub BBassam
4Hamoudi RRifat
5Hamid QQutayba

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AsthmaMajor topic
Interleukin-13Major topic
Airway RemodelingMajor topic
Interleukin-4Major topic
Anti-Asthmatic AgentsMajor topic
Humans
Animals
Th2 Cells
Molecular Targeted Therapy
Severity of Illness Index
Signal Transduction

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
24010902153University of SharjahPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References205

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
138,785,953The Possible Roles of IL-4/IL-13 in the Development of Eosinophil-Predominant Severe Asthma.Biomolecules2024https://conductscience.org/library/papers/38785953PubMed
210,588,591Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial.Am J Respir Crit Care Med1999https://conductscience.org/library/papers/10588591PubMed
320,064,211A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma.BMC Pulm Med2010https://conductscience.org/library/papers/20064211PubMed
416,466,711Interleukin-4 improves the migration of human myogenic precursor cells in vitro and in vivo.Exp Cell Res2006https://conductscience.org/library/papers/16466711PubMed
531,866,859The Intriguing Role of Interleukin 13 in the Pathophysiology of Asthma.Front Pharmacol2019https://conductscience.org/library/papers/31866859PubMed
624,875,618Asthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components.J Allergy Clin Immunol2014https://conductscience.org/library/papers/24875618PubMed
737,397,552The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis: Therapeutic implications.Genes Dis2023https://conductscience.org/library/papers/37397552PubMed
826,074,138Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma.Am J Respir Cell Mol Biol2016https://conductscience.org/library/papers/26074138PubMed
922,561,837Therapies for allergic inflammation: refining strategies to induce tolerance.Nat Med2012https://conductscience.org/library/papers/22561837PubMed
1016,709,936Extracellular matrix regulates enhanced eotaxin expression in asthmatic airway smooth muscle cells.Am J Respir Crit Care Med2006https://conductscience.org/library/papers/16709936PubMed

1 to 10 of 205

See all 205 references

Cited by56

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 63 citations.

PMIDTitleJournalYearIn PapersSource
42,923,234Coordinated transcriptional and epigenetic regulation of type 2 CD8+ T cells in asthma.Front Immunol2026https://conductscience.org/library/papers/42923234PubMed
42,882,442House Dust Mite Induces Distinct Cellular and Extracellular Vesicle-Associated miRNA Signatures in BEAS-2B Cells: Targeted Analysis of IL-4 Responses.Cells2026https://conductscience.org/library/papers/42882442PubMed
42,877,672Immunologic comparison of alpha-gal sensitized and non-sensitized groups from a community based sample.Front Immunol2026https://conductscience.org/library/papers/42877672PubMed
42,839,285Real-world effectiveness of dupilumab in COPD: a German multicenter analysis.Respir Res2026https://conductscience.org/library/papers/42839285PubMed
42,793,127Curcumin Retains Anti-Inflammatory Effects Despite IDO Inhibition-Associated Neutrophilic Shift in OVA-Induced Rat Model.Biomolecules2026https://conductscience.org/library/papers/42793127PubMed
42,789,236Advanced Pulmonary Drug Delivery Systems: A Narrative Review.Pulm Ther2026https://conductscience.org/library/papers/42789236PubMed
42,781,660Correlation analysis of the serum CCR5 and LXA4 levels with airway remodelling in bronchial asthma patients.J Med Biochem2026https://conductscience.org/library/papers/42781660PubMed
42,713,017Interleukin-13 R130Q aggravates airway smooth-muscle phenotypic switching and promotes airway remodeling in severe asthma.Front Physiol2026https://conductscience.org/library/papers/42713017PubMed
42,712,896Pathogenic group 2 innate lymphoid cells as drivers of lung fibrosis in severe asthma.Front Immunol2026https://conductscience.org/library/papers/42712896PubMed
42,666,957Sophocarpine Alleviates Airway Epithelial Cell Inflammation in Asthma via Modulating the Cytokine- Cytokine Receptor and JAK2/STAT3 Signaling Pathways.Drug Des Devel Ther2026https://conductscience.org/library/papers/42666957PubMed

1 to 10 of 56

See all 56 cited by

Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
IGHE3,497PubTator's text mininghttps://conductscience.org/library/genes/3497NCBI Gene
IL133,596PubTator's text mininghttps://conductscience.org/library/genes/3596NCBI Gene
IL43,565PubTator's text mininghttps://conductscience.org/library/genes/3565NCBI Gene
IL53,567PubTator's text mininghttps://conductscience.org/library/genes/3567NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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