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Paper · 40581663

Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma.

Lin B and 24 others. Acta Neuropathol Commun, 2025. Cited by 2 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma. Papers, record 40581663. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/40581663

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma.
PubMed
Journal
Acta Neuropathol Commun
PubMed
Year
2025
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
Citations, by iCite
2
iCite
Revised in PubMed
2026-05-16
PubMed

Authors25

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Lin BBenjamin
2Shelton AKAbigail K
3Smithberger EErin
4Ziebro JJulia
5Skinner KRKasey R
6Bash RERyan E
7Kirkman RRichard
8Stamper AAllie
9Butler MMadison
10Flores AAlex

1 to 10 of 25Source PubMed

See all 25 authors

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
GlioblastomaMajor topic
ErbB ReceptorsMajor topic
Brain NeoplasmsMajor topic
Protein Kinase InhibitorsMajor topic
Synthetic Lethal MutationsMajor topic
Animals
Humans
Mice
Drug Resistance, Neoplasm
Mice, Transgenic
Cell Line, Tumor
Antineoplastic Agents

Source PubMed

Grants33

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P30 CA013148NCI NIH HHSUnited StatesP30CA013148PubMed and NIHNIH RePORTER
R01 NS121319NINDS NIH HHSUnited StatesR01NS121319PubMed and NIHNIH RePORTER
R01 CA227089NCI NIH HHSUnited StatesR01CA227089PubMed and NIHNIH RePORTER
R37CA285434NCI NIH HHSUnited StatesR37CA285434PubMed and NIHNIH RePORTER
U01 CA227954NCI NIH HHSUnited StatesU01CA227954PubMed and NIHNIH RePORTER
R01 NS127424NINDS NIH HHSUnited StatesR01NS127424PubMed and NIHNIH RePORTER
R01NS042645NINDS NIH HHSUnited StatesR01NS042645PubMed and NIHNIH RePORTER
U19 CA264362NCI NIH HHSUnited StatesU19CA264362PubMed and NIHNIH RePORTER
R01 NS080939NINDS NIH HHSUnited StatesR01NS080939PubMed and NIHNIH RePORTER
R37 CA285434NCI NIH HHSUnited StatesR37CA285434PubMed and NIHNIH RePORTER

1 to 10 of 33

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Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References51

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
118,227,510The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.Proc Natl Acad Sci U S A2008https://conductscience.org/library/papers/18227510PubMed
233,062,157Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors.ACS Med Chem Lett2020https://conductscience.org/library/papers/33062157PubMed
336,370,105The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest.Nucleic Acids Res2023https://conductscience.org/library/papers/36370105PubMed
424,120,142The somatic genomic landscape of glioblastoma.Cell2013https://conductscience.org/library/papers/24120142PubMed
529,446,774Proteome-wide identification of ubiquitin interactions using UbIA-MS.Nat Protoc2018https://conductscience.org/library/papers/29446774PubMed
628,379,424Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma.Neuro Oncol2017https://conductscience.org/library/papers/28379424PubMed
723,104,886STAR: ultrafast universal RNA-seq aligner.Bioinformatics2013https://conductscience.org/library/papers/23104886PubMed
831,601,994The great escape: tumour cell plasticity in resistance to targeted therapy.Nat Rev Drug Discov2020https://conductscience.org/library/papers/31601994PubMed
98,845,302Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene.Cell Growth Differ1995https://conductscience.org/library/papers/8845302PubMed
1028,791,656EGFR as a Target for Glioblastoma Treatment: An Unfulfilled Promise.CNS Drugs2017https://conductscience.org/library/papers/28791656PubMed

1 to 10 of 51

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Cited by2

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 2 citations.

PMIDTitleJournalYearIn PapersSource
42,549,406Targeting replication stress in glioblastoma: From genotoxic treatment and inhibitors of the DNA damage response to immunotherapy.Neurooncol Adv2026https://conductscience.org/library/papers/42549406PubMed
41,930,350The Nexus of Stemness, Telomere Stability, and Metabolic Reprogramming in Glioblastoma: Foundations of Tumor Persistence and Targets for Intervention.MedComm (2020)2026https://conductscience.org/library/papers/41930350PubMed

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CDK61,021PubTator's text mininghttps://conductscience.org/library/genes/1021NCBI Gene
CDKN2A1,029PubTator's text mininghttps://conductscience.org/library/genes/1029NCBI Gene
EGFR1,956PubTator's text mininghttps://conductscience.org/library/genes/1956NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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