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Paper · 40835949

Brevilin A, a novel LRRC15 inhibitor, exerts potent anti-rheumatoid arthritis effects by inhibiting the LRRC15/STAT3 signaling pathway.

Qiao Z and 5 others. Arthritis Res Ther, 2025. Cited by 5 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Brevilin A, a novel LRRC15 inhibitor, exerts potent anti-rheumatoid arthritis effects by inhibiting the LRRC15/STAT3 signaling pathway. Papers, record 40835949. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/40835949

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Brevilin A, a novel LRRC15 inhibitor, exerts potent anti-rheumatoid arthritis effects by inhibiting the LRRC15/STAT3 signaling pathway.
PubMed
Journal
Arthritis Res Ther
PubMed
Year
2025
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
5
iCite
Relative citation ratio, by iCite
1.48, provisional
iCite
Revised in PubMed
2026-06-26
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Qiao ZZhiping
2Meng QQiqi
3Xiao BBixia
4Long YYulei
5Liang QQi
6Su TTao

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Arthritis, RheumatoidMajor topic
STAT3 Transcription FactorMajor topic
Signal TransductionMajor topic
Membrane ProteinsMajor topic
Antirheumatic AgentsMajor topic
Animals
Rats
Humans
Mice
Arthritis, Experimental
Male
RAW 264.7 Cells
Female
Synoviocytes
Synovial Membrane
Cell Proliferation

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
82074019National Natural Science Foundation of ChinaPubMed
HOL2024PZ042Young Pearl River Scholar of Guangdong Province, Chinese Medicine Guangdong LaboratoryPubMed
2023KTSCX023Characteristic Innovation Projects of Universities in Guangdong ProvincePubMed
20222042Administration of Traditional Chinese Medicine of Guangdong ProvincePubMed
2025A04J5398Guangzhou Basic and Applied Basic Research FoundationPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References29

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
135,774,606Brevilin A Ameliorates Acute Lung Injury and Inflammation Through Inhibition of NF-κB Signaling via Targeting IKKα/β.Front Pharmacol2022https://conductscience.org/library/papers/35774606PubMed
233,529,910Fibroblast-like synoviocytes in rheumatoid arthritis: Surface markers and phenotypes.Int Immunopharmacol2021https://conductscience.org/library/papers/33529910PubMed
336,171,287LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity.Nature2022https://conductscience.org/library/papers/36171287PubMed
435,879,783Single-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritis.Genome Med2022https://conductscience.org/library/papers/35879783PubMed
539,716,892FGF19-Activated Hepatic Stellate Cells Release ANGPTL4 that Promotes Colorectal Cancer Liver Metastasis.Adv Sci (Weinh)2025https://conductscience.org/library/papers/39716892PubMed
638,101,413BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development.Dev Cell2024https://conductscience.org/library/papers/38101413PubMed
738,240,831Rheumatoid arthritis.Lancet2023https://conductscience.org/library/papers/38240831PubMed
828,612,747Pathogenetic insights from the treatment of rheumatoid arthritis.Lancet2017https://conductscience.org/library/papers/28612747PubMed
937,593,607Brevilin A exerts anti-colorectal cancer effects and potently inhibits STAT3 signaling invitro.Heliyon2023https://conductscience.org/library/papers/37593607PubMed
1016,978,198Synovitis score: discrimination between chronic low-grade and high-grade synovitis.Histopathology2006https://conductscience.org/library/papers/16978198PubMed

1 to 10 of 29

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Cited by4

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 5 citations.

PMIDTitleJournalYearIn PapersSource
42,737,864Natural Bioactive Compounds in Rheumatoid Arthritis: Experimental Evidence from Adjuvant Arthritis Model Supporting Combination Strategies with Methotrexate.Int J Mol Sci2026https://conductscience.org/library/papers/42737864PubMed
42,729,789Luteolin-7-O-rutinoside alleviates rheumatoid arthritis through downregulation of the PI3K/AKT/NF-κB and cell cycle signaling pathways.Front Pharmacol2026https://conductscience.org/library/papers/42729789PubMed
42,589,239The Molecular Structure, Expression, and Emerging Role of the 15-Leucine-Rich Repeat Containing Membrane Protein (LRRC15) in Skeletal Biology and Diseases.Int J Mol Sci2026https://conductscience.org/library/papers/42589239PubMed
42,429,045FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review).Int J Mol Med2026https://conductscience.org/library/papers/42429045PubMed

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
LRRC15131,578PubTator's text mininghttps://conductscience.org/library/genes/131578NCBI Gene
STAT36,774PubTator's text mininghttps://conductscience.org/library/genes/6774NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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