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Paper · 42589239

The Molecular Structure, Expression, and Emerging Role of the 15-Leucine-Rich Repeat Containing Membrane Protein (LRRC15) in Skeletal Biology and Diseases.

Lin ZH and 4 others. Int J Mol Sci, 2026. Cited by 0 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The Molecular Structure, Expression, and Emerging Role of the 15-Leucine-Rich Repeat Containing Membrane Protein (LRRC15) in Skeletal Biology and Diseases. Papers, record 42589239. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42589239

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The Molecular Structure, Expression, and Emerging Role of the 15-Leucine-Rich Repeat Containing Membrane Protein (LRRC15) in Skeletal Biology and Diseases.
PubMed
Journal
Int J Mol Sci
PubMed
Year
2026
PubMed
Publication types
Journal Article, Review
PubMed
Citations, by iCite
0
iCite
Revised in PubMed
2026-08-15
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Lin ZHZi-Hao
2Hu ZCZhi-Chao
3Zhang CQChang-Qing
4Zhu ZZZhen-Zhong
5Tang QQianhttps://orcid.org/0000-0002-4030-766X

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Membrane ProteinsMajor topic
Bone DiseasesMajor topic
Bone and BonesMajor topic
Humans
Animals
Signal Transduction
Osteosarcoma

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
82202665National Natural Science Foundation of ChinaPubMed
82172400National Natural Science Foundation of ChinaPubMed
ynyq202403Shanghai Sixth People's HospitalPubMed
ynqn202402Shanghai Sixth People's HospitalPubMed
GZC20231639Postdoctoral Fellowship Program of CPSFPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References79

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
120,193,003Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis.Immunol Rev2010https://conductscience.org/library/papers/20193003PubMed
234,702,854Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis.Sci Rep2021https://conductscience.org/library/papers/34702854PubMed
319,252,480The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex.Nature2009https://conductscience.org/library/papers/19252480PubMed
438,051,601Leucine-Rich Repeat Containing 15-Mediated Cell Adhesion Is Essential for Integrin Signaling in TGF-β1-Induced PDL Fibroblastic Differentiation.Stem Cells2024https://conductscience.org/library/papers/38051601PubMed
540,469,190Role of TGFβ-activated cancer-associated fibroblasts in the resistance to checkpoint blockade immunotherapy.Front Oncol2025https://conductscience.org/library/papers/40469190PubMed
625,613,900Proteomics. Tissue-based map of the human proteome.Science2015https://conductscience.org/library/papers/25613900PubMed
738,827,307Gene expression and immune infiltration analysis comparing lesioned and preserved subchondral bone in osteoarthritis.PeerJ2024https://conductscience.org/library/papers/38827307PubMed
831,852,685Dual role of Jam3b in early hematopoietic and vascular development.Development2020https://conductscience.org/library/papers/31852685PubMed
940,835,949Brevilin A, a novel LRRC15 inhibitor, exerts potent anti-rheumatoid arthritis effects by inhibiting the LRRC15/STAT3 signaling pathway.Arthritis Res Ther2025https://conductscience.org/library/papers/40835949PubMed
1026,688,464Mesenchymal Stem Cells and Their Clinical Applications in Osteoarthritis.Cell Transplant2016https://conductscience.org/library/papers/26688464PubMed

1 to 10 of 79

See all 79 references

Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 0 citations.

None in this release.

Genes5

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CTNNB11,499PubTator's text mininghttps://conductscience.org/library/genes/1499NCBI Gene
IL1B3,553PubTator's text mininghttps://conductscience.org/library/genes/3553NCBI Gene
LRRC15131,578PubTator's text mininghttps://conductscience.org/library/genes/131578NCBI Gene
NFKB14,790PubTator's text mininghttps://conductscience.org/library/genes/4790NCBI Gene
TGFB17,040PubTator's text mininghttps://conductscience.org/library/genes/7040NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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