Paper · 40925966

Structure-Encoded Location Biased Signaling in a Class B GPCR: Focus on the PTH Type 1 Receptor.

Peña KA and 1 other. Handb Exp Pharmacol, 2026. Cited by 0 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Structure-Encoded Location Biased Signaling in a Class B GPCR: Focus on the PTH Type 1 Receptor. Papers, record 40925966. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/40925966

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Structure-Encoded Location Biased Signaling in a Class B GPCR: Focus on the PTH Type 1 Receptor.; PubMed
Journal: Handb Exp Pharmacol; PubMed
Year: 2026; PubMed
Publication types: Journal Article, Review; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/40925966/; PubMed
DOI: https://doi.org/10.1007/164_2025_763; PubMed
The journal: https://conductscience.org/library/journal-index/7902231; PubMed
Citations, by iCite: 0; iCite
Revised in PubMed: 2026-01-02; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Peña KA	Karina A
2	Vilardaga JP	Jean-Pierre

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Receptor, Parathyroid Hormone, Type 1	Major topic
Signal Transduction	Major topic
Humans
Animals
Cyclic AMP
Ligands
Receptors, G-Protein-Coupled

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
I01 BX006371	BLRD VA	United States	I01BX006371	PubMed	NIH RePORTER
R01 DK102495	NIDDK NIH HHS	United States	R01DK102495	PubMed	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References101

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	1,313,566	Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.	Proc Natl Acad Sci U S A	1992	https://conductscience.org/library/papers/1313566	PubMed
2	24,643,196	Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias.	PLoS One	2014	https://conductscience.org/library/papers/24643196	PubMed
3	32,637,467	Effects of abaloparatide and teriparatide on bone resorption and bone formation in female mice.	Bone Rep	2020	https://conductscience.org/library/papers/32637467	PubMed
4	35,302,493	Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.	Elife	2022	https://conductscience.org/library/papers/35302493	PubMed
5	11,927,592	A highly effective dominant negative alpha s construct containing mutations that affect distinct functions inhibits multiple Gs-coupled receptor signaling pathways.	J Biol Chem	2002	https://conductscience.org/library/papers/11927592	PubMed
6	18,758,808	Regulation of phosphate transport in proximal tubules.	Pflugers Arch	2009	https://conductscience.org/library/papers/18758808	PubMed
7	33,796,549	NMR Characterization of the Interactions Between Glycosaminoglycans and Proteins.	Front Mol Biosci	2021	https://conductscience.org/library/papers/33796549	PubMed
8	19,688,034	Persistent cAMP-signals triggered by internalized G-protein-coupled receptors.	PLoS Biol	2009	https://conductscience.org/library/papers/19688034	PubMed
9	17,761,594	Mechanisms of anabolic therapies for osteoporosis.	N Engl J Med	2007	https://conductscience.org/library/papers/17761594	PubMed
10	26,912,788	Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth.	Mol Biol Cell	2016	https://conductscience.org/library/papers/26912788	PubMed

1 to 10 of 101

See all 101 references

Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 0 citations.

None in this release.

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
PTH1R	5,745	PubTator's text mining	https://conductscience.org/library/genes/5745

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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