Paper · 24643196

Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias.

Andreassen KV and 7 others. PLoS One, 2014. Cited by 66 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias. Papers, record 24643196. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/24643196

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias.; PubMed
Journal: PLoS One; PubMed
Year: 2014; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/24643196/; PubMed
DOI: https://doi.org/10.1371/journal.pone.0092042; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC3958426/; PubMed
The journal: https://conductscience.org/library/journal-index/101285081; PubMed
Citations, by iCite: 66; iCite
Relative citation ratio, by iCite: 2.16; iCite
Revised in PubMed: 2021-10-21; PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Andreassen KV	Kim Vietz
2	Hjuler ST	Sara Toftegaard
3	Furness SG	Sebastian G
4	Sexton PM	Patrick M
5	Christopoulos A	Arthur
6	Nosjean O	Olivier
7	Karsdal MA	Morten Asser
8	Henriksen K	Kim

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Calcitonin	Major topic
Cyclic AMP	Major topic
Receptors, Calcitonin	Major topic
Signal Transduction	Major topic
Animals
Arrestins
Cell Line
Gene Expression Regulation
Humans
Ligands
Protein Transport
Salmon
Species Specificity
Time Factors
Transgenes
beta-Arrestins

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References36

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	1,847,755	Cell cycle-dependent coupling of the calcitonin receptor to different G proteins.	Science	1991	https://conductscience.org/library/papers/1847755	PubMed
2	11,996,901	Forty years of calcitonin--where are we now? A tribute to the work of Iain Macintyre, FRS.	Bone	2002	https://conductscience.org/library/papers/11996901	PubMed
3	7,723,741	Divergent structural requirements exist for calcitonin receptor binding specificity and adenylate cyclase activation.	Mol Pharmacol	1995	https://conductscience.org/library/papers/7723741	PubMed
4	3,032,571	Control of cyclic adenosine 3',5'-monophosphate production in osteoclasts: calcitonin-induced persistent activation and homologous desensitization of adenylate cyclase.	Endocrinology	1987	https://conductscience.org/library/papers/3032571	PubMed
5	20,161,833	HTRF: A technology tailored for drug discovery - a review of theoretical aspects and recent applications.	Curr Chem Genomics	2009	https://conductscience.org/library/papers/20161833	PubMed
6	21,615,667	A novel oral form of salmon calcitonin improves glucose homeostasis and reduces body weight in diet-induced obese rats.	Diabetes Obes Metab	2011	https://conductscience.org/library/papers/21615667	PubMed
7	15,119,591	Photoaffinity scanning in the mapping of the peptide receptor interface of class II G protein-coupled receptors.	J Pept Sci	2004	https://conductscience.org/library/papers/15119591	PubMed
8	19,701,185	Sustained cyclic AMP production by parathyroid hormone receptor endocytosis.	Nat Chem Biol	2009	https://conductscience.org/library/papers/19701185	PubMed
9	16,492,540	Receptor pharmacology.	Adv Pharmacol	2005	https://conductscience.org/library/papers/16492540	PubMed
10	1,324,163	Differential effects of the 3',5'-cyclic adenosine monophosphate and protein kinase C pathways on the response of isolated rat osteoclasts to calcitonin.	Endocrinology	1992	https://conductscience.org/library/papers/1324163	PubMed

1 to 10 of 36

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Cited by32

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 66 citations.

PMID	Title	Journal	Year	In Papers	Source
42,265,185	Dual amylin and calcitonin receptor agonists as multifaceted disease-modifying osteoarthritis drugs.	Int J Obes (Lond)	2026	https://conductscience.org/library/papers/42265185	PubMed
41,268,902	Functional characterization of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome.	Elife	2025	https://conductscience.org/library/papers/41268902	PubMed
40,925,966	Structure-Encoded Location Biased Signaling in a Class B GPCR: Focus on the PTH Type 1 Receptor.	Handb Exp Pharmacol	2026	https://conductscience.org/library/papers/40925966	PubMed
40,828,907	Amylin receptor subunit interactions are modulated by agonists and determine signaling.	Sci Signal	2025	https://conductscience.org/library/papers/40828907	PubMed
40,609,154	Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3.	EBioMedicine	2025	https://conductscience.org/library/papers/40609154	PubMed
40,172,014	Characterization of the Two-Domain Peptide Binding Mechanism of the Human CGRP Receptor for CGRP and the Ultrahigh Affinity ssCGRP Variant.	Biochemistry	2025	https://conductscience.org/library/papers/40172014	PubMed
40,168,114	Prolonged signaling of backbone-modified glucagon-like peptide-1 analogues with diverse receptor trafficking.	Proc Natl Acad Sci U S A	2025	https://conductscience.org/library/papers/40168114	PubMed
39,185,315	Assessing the immunogenicity risk of salmon calcitonin peptide impurities using in silico and in vitro methods.	Front Pharmacol	2024	https://conductscience.org/library/papers/39185315	PubMed
36,546,772	New Insights into the Structure and Function of Class B1 GPCRs.	Endocr Rev	2023	https://conductscience.org/library/papers/36546772	PubMed
36,289,629	The Impact of Exposure Profile on the Efficacy of Dual Amylin and Calcitonin Receptor Agonist Therapy.	Biomedicines	2022	https://conductscience.org/library/papers/36289629	PubMed

1 to 10 of 32

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Genes5

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
ARRB1	408	PubTator's text mining	https://conductscience.org/library/genes/408	NCBI Gene
CALCA	796	PubTator's text mining	https://conductscience.org/library/genes/796	NCBI Gene
CALCR	799	PubTator's text mining	https://conductscience.org/library/genes/799	NCBI Gene
MAPK1	5,594	PubTator's text mining	https://conductscience.org/library/genes/5594	NCBI Gene
VN1R17P	441,931	PubTator's text mining	https://conductscience.org/library/genes/441931	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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