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Paper · 20161833

HTRF: A technology tailored for drug discovery - a review of theoretical aspects and recent applications.

Degorce F and 5 others. Curr Chem Genomics, 2009. Cited by 374 papers, by iCite.

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ConductScience Library. HTRF: A technology tailored for drug discovery - a review of theoretical aspects and recent applications. Papers, record 20161833. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/20161833

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
HTRF: A technology tailored for drug discovery - a review of theoretical aspects and recent applications.
PubMed
Journal
Curr Chem Genomics
PubMed
Year
2009
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
374
iCite
Relative citation ratio, by iCite
8.8
iCite
Revised in PubMed
2021-10-20
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Degorce FFrançois
2Card AAmy
3Soh SSharon
4Trinquet EEric
5Knapik GPGlenn P
6Xie BBing

Source PubMed

Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References70

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
116,965,760D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation.Anal Biochem2006https://conductscience.org/library/papers/16965760PubMed
220,161,828Cellular Ser/Thr-kinase assays using generic peptide substrates.Curr Chem Genomics2008https://conductscience.org/library/papers/20161828PubMed
318,626,113HTRF-based assay for microsomal prostaglandin E2 synthase-1 activity.J Biomol Screen2008https://conductscience.org/library/papers/18626113PubMed
412,419,336Homogeneous time-resolved fluorescence assay for identifying p53 interactions with its protein partners, directly in a cellular extract.Anal Biochem2002https://conductscience.org/library/papers/12419336PubMed
510,838,427HTRF(R) Technology.J Biomol Screen1999https://conductscience.org/library/papers/10838427PubMed
620,161,824Development of a HTRF kinase assay for determination of Syk activity.Curr Chem Genomics2008https://conductscience.org/library/papers/20161824PubMed
718,212,126Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass.Proc Natl Acad Sci U S A2008https://conductscience.org/library/papers/18212126PubMed
810,539,989Application of homogeneous time-resolved fluorescence (HTRFTM) to monitor poly-ubiquitination of wild-type p53.Comb Chem High Throughput Screen1999https://conductscience.org/library/papers/10539989PubMed
917,913,892Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens.Proc Natl Acad Sci U S A2007https://conductscience.org/library/papers/17913892PubMed
1018,267,118Identification and characterization of small-molecule inhibitors of Tie2 kinase.FEBS Lett2008https://conductscience.org/library/papers/18267118PubMed

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Cited by184

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 374 citations.

PMIDTitleJournalYearIn PapersSource
42,794,777Deubiquitinases as Regulators and Therapeutic Targets in Vascular Diseases.Int J Mol Sci2026https://conductscience.org/library/papers/42794777PubMed
42,768,037Mapping of dynamic allostery within p38 alpha kinase via network analyses and NMR spectroscopy.Nat Commun2026https://conductscience.org/library/papers/42768037PubMed
42,712,076A Biweekly GLP-1R Agonist Designed With Drug-Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability.Diabetes Obes Metab2026https://conductscience.org/library/papers/42712076PubMed
42,446,647Screening the Tox21 Compound Library for Chemicals That Stimulate the Adrenergic β1 Receptor.Chem Res Toxicol2026https://conductscience.org/library/papers/42446647PubMed
42,380,604Mechanisms that matter: unbiased cellular screening for degraders.NPJ Drug Discov2025https://conductscience.org/library/papers/42380604PubMed
42,347,521Biophysical and Biochemical Assays for Screening Small Molecule Inhibitors Targeting Toxin-Ribosome Interactions.Toxins (Basel)2026https://conductscience.org/library/papers/42347521PubMed
42,297,998Integrating HTS and CRISPR/Cas for next-generation nucleic and non-nucleic acid diagnostics.Mol Genet Genomics2026https://conductscience.org/library/papers/42297998PubMed
42,266,899Boosting peptide half-life: enabling efficient generation of Fc-peptide conjugates.Chem Sci2026https://conductscience.org/library/papers/42266899PubMed
42,261,660A Highly Selective, Cell-Permeable Fluorescent Probe for Imaging Histone Deacetylase 6 in Live Cells.J Am Chem Soc2026https://conductscience.org/library/papers/42261660PubMed
42,088,608Comparative analysis for optimal LSD1 inhibitors evaluation techniques: pros and cons.J Pharm Anal2026https://conductscience.org/library/papers/42088608PubMed

1 to 10 of 184

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Genes40

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ADORA2A135PubTator's text mininghttps://conductscience.org/library/genes/135NCBI Gene
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
APP351PubTator's text mininghttps://conductscience.org/library/genes/351NCBI Gene
AVP551PubTator's text mininghttps://conductscience.org/library/genes/551NCBI Gene
BRAF673PubTator's text mininghttps://conductscience.org/library/genes/673NCBI Gene
CALR811PubTator's text mininghttps://conductscience.org/library/genes/811NCBI Gene
CD28940PubTator's text mininghttps://conductscience.org/library/genes/940NCBI Gene
CD80941PubTator's text mininghttps://conductscience.org/library/genes/941NCBI Gene
CD86942PubTator's text mininghttps://conductscience.org/library/genes/942NCBI Gene
CX3CL16,376PubTator's text mininghttps://conductscience.org/library/genes/6376NCBI Gene

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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