Paper · 41499130

Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer.

Herzog SK and 18 others. Cancer Res, 2026. Cited by 0 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer. Papers, record 41499130. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41499130

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer.; PubMed
Journal: Cancer Res; PubMed
Year: 2026; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/41499130/; PubMed
DOI: https://doi.org/10.1158/0008-5472.can-24-3891; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC12898867/; PubMed
The journal: https://conductscience.org/library/journal-index/2984705R; PubMed
Citations, by iCite: 0; iCite
Revised in PubMed: 2026-09-20; PubMed

Authors19

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Herzog SK	Sarah K	https://orcid.org/0000-0003-3782-7389
2	Stevens JH	Jessica H	https://orcid.org/0009-0005-9741-9928
3	Gu G	Guowei	https://orcid.org/0000-0001-8845-4055
4	Grimm SL	Sandra L	https://orcid.org/0000-0002-0682-3134
5	Cardoza K	Kloma	https://orcid.org/0009-0006-0488-7894
6	Hawkins AGM	Autumn G M	https://orcid.org/0009-0001-8189-3159
7	Lin H	Hangqing	https://orcid.org/0009-0009-7691-8364
8	Ramos D	Daniela	https://orcid.org/0000-0002-3848-6478
9	Beyer AR	Amanda R	https://orcid.org/0009-0009-9244-1439
10	Edwards DG	David G	https://orcid.org/0000-0001-8002-0607

1 to 10 of 19Source PubMed

See all 19 authors

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Breast Neoplasms	Major topic
DNA Damage	Major topic
Estrogen Receptor alpha	Major topic
Mutation	Major topic
Humans
Female
Animals
Piperazines
Cell Line, Tumor
Poly(ADP-ribose) Polymerase Inhibitors
Mice
Poly (ADP-Ribose) Polymerase-1
Xenograft Model Antitumor Assays
Phthalazines
DNA Replication
Benzimidazoles
Aminopyridines

Source PubMed

Grants20

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
RP180712	Cancer Prevention and Research Institute of Texas (CPRIT)			PubMed	PubMed
S10 OD032185	NIH HHS	United States	S10OD032185	PubMed	NIH RePORTER
RC2 ES018789	NIEHS NIH HHS	United States	RC2ES018789	PubMed	NIH RePORTER
T32 2389301302	National Cancer Institute (NCI)			PubMed	PubMed
R01 CA207270	NCI NIH HHS	United States	R01CA207270	PubMed	NIH RePORTER
P42 ES027725	NIEHS NIH HHS	United States	P42ES027725	PubMed	NIH RePORTER
P30 DK056338	NIDDK NIH HHS	United States	P30DK056338	PubMed	NIH RePORTER
S10 OD030414	NIH HHS	United States	S10OD030414	PubMed	NIH RePORTER
24-055	Breast Cancer Research Foundation (BCRF)			PubMed	PubMed
F31 CA260983	NCI NIH HHS	United States	F31CA260983	PubMed	NIH RePORTER

1 to 10 of 20

See all 20 grants

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References68

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	29,950,726	High speed of fork progression induces DNA replication stress and genomic instability.	Nature	2018	https://conductscience.org/library/papers/29950726	PubMed
2	23,118,055	Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.	Cancer Res	2012	https://conductscience.org/library/papers/23118055	PubMed
3	37,679,326	A new wave of innovations within the DNA damage response.	Signal Transduct Target Ther	2023	https://conductscience.org/library/papers/37679326	PubMed
4	30,177,435	The comings and goings of PARP-1 in response to DNA damage.	DNA Repair (Amst)	2018	https://conductscience.org/library/papers/30177435	PubMed
5	34,637,323	Clinical Review on the Management of Hormone Receptor-Positive Metastatic Breast Cancer.	JCO Oncol Pract	2022	https://conductscience.org/library/papers/34637323	PubMed
6	19,910,308	edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.	Bioinformatics	2010	https://conductscience.org/library/papers/19910308	PubMed
7	22,955,987	GENCODE: the reference human genome annotation for The ENCODE Project.	Genome Res	2012	https://conductscience.org/library/papers/22955987	PubMed
8	34,508,175	A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors.	Oncogene	2021	https://conductscience.org/library/papers/34508175	PubMed
9	26,947,331	Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial.	Lancet Oncol	2016	https://conductscience.org/library/papers/26947331	PubMed
10	17,406,208	The comet assay: a method to measure DNA damage in individual cells.	Nat Protoc	2006	https://conductscience.org/library/papers/17406208	PubMed

1 to 10 of 68

See all 68 references

Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 0 citations.

None in this release.

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
EREG	2,069	PubTator's text mining	https://conductscience.org/library/genes/2069	NCBI Gene
ESR1	2,099	PubTator's text mining	https://conductscience.org/library/genes/2099	NCBI Gene
PARP1	142	PubTator's text mining	https://conductscience.org/library/genes/142	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/41499130

GET https://conductscience.org/api/papers/v1/41499130/references?page=2

API reference For AI assistants