Paper · 41565619

Positive feedback regulation between USP8 and Hippo/YAP axis drives triple-negative breast cancer progression.

Li X and 9 others. Cell Death Dis, 2026. Cited by 1 paper, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Positive feedback regulation between USP8 and Hippo/YAP axis drives triple-negative breast cancer progression. Papers, record 41565619. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41565619

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Positive feedback regulation between USP8 and Hippo/YAP axis drives triple-negative breast cancer progression.; PubMed
Journal: Cell Death Dis; PubMed
Year: 2026; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/41565619/; PubMed
DOI: https://doi.org/10.1038/s41419-025-08356-8; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC12830590/; PubMed
The journal: https://conductscience.org/library/journal-index/101524092; PubMed
Citations, by iCite: 1; iCite
Revised in PubMed: 2026-06-30; PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Li X	Xin	https://orcid.org/0009-0007-3315-3408
2	Yang P	Penghe
3	Wang T	Tianshi
4	Su P	Peng	https://orcid.org/0000-0002-7000-0474
5	Zhang C	Chenmiao
6	Fangyu S	Shen
7	Yang H	Huijie
8	Zhu J	Jian	https://orcid.org/0000-0003-3596-4339
9	Tan X	Xiaodong	https://orcid.org/0000-0003-0862-1306
10	Zhuang T	Ting	https://orcid.org/0000-0002-6308-1253

Source PubMed

Topics19

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Triple Negative Breast Neoplasms	Major topic
Protein Serine-Threonine Kinases	Major topic
Ubiquitin Thiolesterase	Major topic
Adaptor Proteins, Signal Transducing	Major topic
Transcription Factors	Major topic
Feedback, Physiological	Major topic
Endopeptidases	Major topic
Phosphoproteins	Major topic
Humans
Female
Hippo Signaling Pathway
YAP-Signaling Proteins
Ubiquitination
Signal Transduction
Cell Line, Tumor
Disease Progression
Gene Expression Regulation, Neoplastic
Animals
Endosomal Sorting Complexes Required for Transport

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References40

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	31,443,516	Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer-How We Can Rise to the Challenge.	Cells	2019	https://conductscience.org/library/papers/31443516	PubMed
2	36,759,723	The oncogenic roles and clinical implications of YAP/TAZ in breast cancer.	Br J Cancer	2023	https://conductscience.org/library/papers/36759723	PubMed
3	19,008,097	What is triple-negative breast cancer?	Eur J Cancer	2008	https://conductscience.org/library/papers/19008097	PubMed
4	35,361,799	USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy.	Nat Commun	2022	https://conductscience.org/library/papers/35361799	PubMed
5	32,863,938	Regulation of Hippo/YAP signaling and Esophageal Squamous Carcinoma progression by an E3 ubiquitin ligase PARK2.	Theranostics	2020	https://conductscience.org/library/papers/32863938	PubMed
6	31,765,611	GDF15 induced by compressive force contributes to osteoclast differentiation in human periodontal ligament cells.	Exp Cell Res	2020	https://conductscience.org/library/papers/31765611	PubMed
7	27,485,598	Genetic variations in the Hippo signaling pathway and breast cancer risk in African American women in the AMBER Consortium.	Carcinogenesis	2016	https://conductscience.org/library/papers/27485598	PubMed
8	34,813,758	Deubiquitinases: From mechanisms to their inhibition by small molecules.	Mol Cell	2022	https://conductscience.org/library/papers/34813758	PubMed
9	32,206,112	A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy.	Theranostics	2020	https://conductscience.org/library/papers/32206112	PubMed
10	35,811,497	USP8 promotes cancer progression and extracellular vesicle-mediated CD8+ T cell exhaustion by deubiquitinating the TGF-β receptor TβRII.	EMBO J	2022	https://conductscience.org/library/papers/35811497	PubMed

1 to 10 of 40

See all 40 references

Cited by1

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1 citation.

PMID	Title	Journal	Year	In Papers
41,926,654	Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple-Negative Breast Cancer by Disrupting the Hippo-YAP/TEAD4-PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation.	Adv Sci (Weinh)	2026	https://conductscience.org/library/papers/41926654

Source PubMed

Genes17

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
ANXA5	308	PubTator's text mining	https://conductscience.org/library/genes/308	NCBI Gene
CCN1	3,491	PubTator's text mining	https://conductscience.org/library/genes/3491	NCBI Gene
CCN2	1,490	PubTator's text mining	https://conductscience.org/library/genes/1490	NCBI Gene
EGFR	1,956	PubTator's text mining	https://conductscience.org/library/genes/1956	NCBI Gene
ERBB2	2,064	PubTator's text mining	https://conductscience.org/library/genes/2064	NCBI Gene
FOSB	2,354	PubTator's text mining	https://conductscience.org/library/genes/2354	NCBI Gene
FOSL1	8,061	PubTator's text mining	https://conductscience.org/library/genes/8061	NCBI Gene
MYC	4,609	PubTator's text mining	https://conductscience.org/library/genes/4609	NCBI Gene
OTUB1	55,611	PubTator's text mining	https://conductscience.org/library/genes/55611	NCBI Gene
POMC	5,443	PubTator's text mining	https://conductscience.org/library/genes/5443	NCBI Gene

1 to 10 of 17

See all 17 genes

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/41565619

GET https://conductscience.org/api/papers/v1/41565619/references?page=2

API reference For AI assistants