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Paper · 41579375

SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring.

Vold VA and 8 others. Cell Rep, 2026. Cited by 0 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring. Papers, record 41579375. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41579375

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring.
PubMed
Journal
Cell Rep
PubMed
Year
2026
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
0
iCite
Revised in PubMed
2026-08-13
PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Vold VAVictoria Amstrup
2Yang JJie
3Østergaard MMaiken
4Lassen ASAnna Schrøder
5Kádková AAnna
6Kumar AAvinash
7Walter AMAlexander M
8Zhang YYongli
9Sørensen JBJakob B

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Synaptosomal-Associated Protein 25Major topic
Synaptic TransmissionMajor topic
SNARE ProteinsMajor topic
Animals
Humans
Neurons
Mutation

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
R35 GM131714NIGMS NIH HHSUnited StatesR35GM131714PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References93

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
117,728,451Differential abilities of SNAP-25 homologs to support neuronal function.J Neurosci2007https://conductscience.org/library/papers/17728451PubMed
215,935,678SNARE complexes and neuroexocytosis: how many, how close?Trends Biochem Sci2005https://conductscience.org/library/papers/15935678PubMed
338,298,782Reduced MUNC18-1 Levels, Synaptic Proteome Changes, and Altered Network Activity in STXBP1-Related Disorder Patient Neurons.Biol Psychiatry Glob Open Sci2024https://conductscience.org/library/papers/38298782PubMed
436,876,590Morphofunctional changes at the active zone during synaptic vesicle exocytosis.EMBO Rep2023https://conductscience.org/library/papers/36876590PubMed
529,056,461Two Disease-Causing SNAP-25B Mutations Selectively Impair SNARE C-terminal Assembly.J Mol Biol2018https://conductscience.org/library/papers/29056461PubMed
639,793,049A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release.Proc Natl Acad Sci U S A2025https://conductscience.org/library/papers/39793049PubMed
79,529,252SNAREpins: minimal machinery for membrane fusion.Cell1998https://conductscience.org/library/papers/9529252PubMed
830,570,144Synaptotagmin oligomers are necessary and can be sufficient to form a Ca2+ -sensitive fusion clamp.FEBS Lett2019https://conductscience.org/library/papers/30570144PubMed
930,690,332Unc13: a multifunctional synaptic marvel.Curr Opin Neurobiol2019https://conductscience.org/library/papers/30690332PubMed
1036,454,760A dynamic template complex mediates Munc18-chaperoned SNARE assembly.Proc Natl Acad Sci U S A2022https://conductscience.org/library/papers/36454760PubMed

Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 0 citations.

None in this release.

Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
SNAP256,616PubTator's text mininghttps://conductscience.org/library/genes/6616NCBI Gene
SNAR-E100,170,220PubTator's text mininghttps://conductscience.org/library/genes/100170220NCBI Gene
STXBP16,812PubTator's text mininghttps://conductscience.org/library/genes/6812NCBI Gene
VAMP26,844PubTator's text mininghttps://conductscience.org/library/genes/6844NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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