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Paper · 41844151

Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks.

Li S and 16 others. Mol Cell, 2026. Cited by 5 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks. Papers, record 41844151. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41844151

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks.
PubMed
Journal
Mol Cell
PubMed
Year
2026
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural
PubMed
Citations, by iCite
5
iCite
Relative citation ratio, by iCite
2.64, provisional
iCite
Revised in PubMed
2026-10-24
PubMed

Authors17

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Li SShibo
2Zhao YYuqin
3Li YYouhang
4Shah SBSameer Bikram
5Shi YYanmeng
6Nguyen TTran
7Wang ZZi
8Chang CYChia-Yu
9Ray AAnagh
10Bu THTe-Hsuan

1 to 10 of 17Source PubMed

See all 17 authors

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
DNA Breaks, Double-StrandedMajor topic
DNA ReplicationMajor topic
DNA End-Joining RepairMajor topic
Humans
DNA Polymerase theta
DNA-Directed DNA Polymerase
Ataxia Telangiectasia Mutated Proteins
MRE11 Homologue Protein
DNA-Binding Proteins
Replication Protein A

Source PubMed

Grants7

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R35 GM141868NIGMS NIH HHSUnited StatesR35GM141868PubMedNIH RePORTER
R01 CA244912NCI NIH HHSUnited StatesR01CA244912PubMedNIH RePORTER
R01 CA187052NCI NIH HHSUnited StatesR01CA187052PubMedNIH RePORTER
R01 GM080677NIGMS NIH HHSUnited StatesR01GM080677PubMedNIH RePORTER
R01 CA294646NCI NIH HHSUnited StatesR01CA294646PubMedNIH RePORTER
R01 CA197995NCI NIH HHSUnited StatesR01CA197995PubMedNIH RePORTER
R01 CA270335NCI NIH HHSUnited StatesR01CA270335PubMedNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Update of41,648,590Microhomology-mediated end joining acts directly on replication forks to repair single-ended double strand breaks.https://conductscience.org/library/papers/41648590

Source PubMed

References91

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
121,376,230Hallmarks of cancer: the next generation.Cell2011https://conductscience.org/library/papers/21376230PubMed
228,668,117Expression and Structural Analyses of Human DNA Polymerase θ (POLQ).Methods Enzymol2017https://conductscience.org/library/papers/28668117PubMed
330,284,473SLX4: multitasking to maintain genome stability.Crit Rev Biochem Mol Biol2018https://conductscience.org/library/papers/30284473PubMed
425,275,444Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.PLoS Genet2014https://conductscience.org/library/papers/25275444PubMed
527,264,557DNA polymerase θ (POLQ), double-strand break repair, and cancer.DNA Repair (Amst)2016https://conductscience.org/library/papers/27264557PubMed
636,344,511Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51.Nat Commun2022https://conductscience.org/library/papers/36344511PubMed
732,234,782Mechanistic basis for microhomology identification and genome scarring by polymerase theta.Proc Natl Acad Sci U S A2020https://conductscience.org/library/papers/32234782PubMed
824,496,117A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites.Nat Commun2014https://conductscience.org/library/papers/24496117PubMed
920,033,038Complex landscapes of somatic rearrangement in human breast cancer genomes.Nature2009https://conductscience.org/library/papers/20033038PubMed
1027,001,513Distinct genetic control of homologous recombination repair of Cas9-induced double-strand breaks, nicks and paired nicks.Nucleic Acids Res2016https://conductscience.org/library/papers/27001513PubMed

1 to 10 of 91

See all 91 references

Cited by3

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 5 citations.

PMIDTitleJournalYearIn PapersSource
42,549,406Targeting replication stress in glioblastoma: From genotoxic treatment and inhibitors of the DNA damage response to immunotherapy.Neurooncol Adv2026https://conductscience.org/library/papers/42549406PubMed
42,522,093DNA polymerase theta (Polθ): a novel candidate for targeted cancer therapy.Cancer Biol Ther2026https://conductscience.org/library/papers/42522093PubMed
42,239,093Direct Mapping of CDK2 Substrates in Embryonic Stem Cells Uncovers an AP-Site Repair Mechanism via HMCES Phosphorylation.bioRxiv2026https://conductscience.org/library/papers/42239093PubMed

Genes5

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ATR545PubTator's text mininghttps://conductscience.org/library/genes/545NCBI Gene
MRE114,361PubTator's text mininghttps://conductscience.org/library/genes/4361NCBI Gene
POLQ10,721PubTator's text mininghttps://conductscience.org/library/genes/10721NCBI Gene
RBBP85,932PubTator's text mininghttps://conductscience.org/library/genes/5932NCBI Gene
RPA16,117PubTator's text mininghttps://conductscience.org/library/genes/6117NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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