Paper · 42332008

Losartan shows limited benefit in preclinical models of Geleophysic dysplasia.

Morales AA and 6 others. Sci Rep, 2026. Cited by 0 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Losartan shows limited benefit in preclinical models of Geleophysic dysplasia. Papers, record 42332008. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42332008

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Losartan shows limited benefit in preclinical models of Geleophysic dysplasia.; PubMed
Journal: Sci Rep; PubMed
Year: 2026; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/42332008/; PubMed
DOI: https://doi.org/10.1038/s41598-026-58527-6; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13574788/; PubMed
The journal: https://conductscience.org/library/journal-index/101563288; PubMed
Citations, by iCite: 0; iCite
Revised in PubMed: 2026-10-05; PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Morales AA	Alejo A
2	Camarena V	Vladimir
3	Peart L	LéShon
4	Smithson S	Sarah
5	Walz K	Katherina
6	Wang G	Gaofeng
7	Tekin M	Mustafa

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Losartan	Major topic
Bone Diseases, Developmental	Major topic
Angiotensin II Type 1 Receptor Blockers	Major topic
Animals
Mice
Humans
Fibroblasts
Signal Transduction
Disease Models, Animal
Transforming Growth Factor beta1
Fibrillin-1
Transforming Growth Factor beta
Extracellular Matrix

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References71

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	11,480,433	Fetal toxic effects and angiotensin-II-receptor antagonists.	Lancet	2001	https://conductscience.org/library/papers/11480433	PubMed
2	1,860,873	Purification and partial characterization of fibrillin, a cysteine-rich structural component of connective tissue microfibrils.	J Biol Chem	1991	https://conductscience.org/library/papers/1860873	PubMed
3	27,068,007	Mutations in LTBP3 cause acromicric dysplasia and geleophysic dysplasia.	J Med Genet	2016	https://conductscience.org/library/papers/27068007	PubMed
4	25,899,461	New recessive truncating mutation in LTBP3 in a family with oligodontia, short stature, and mitral valve prolapse.	Am J Med Genet A	2015	https://conductscience.org/library/papers/25899461	PubMed
5	30,303,737	Impairment of chondrogenesis and microfibrillar network in Adamtsl2 deficiency.	FASEB J	2019	https://conductscience.org/library/papers/30303737	PubMed
6	40,520,105	The matricellular protein ADAMTS-like 2 regulates differentiation of skeletal muscle-resident fibro-adipogenic progenitor cells.	iScience	2025	https://conductscience.org/library/papers/40520105	PubMed
7	33,082,559	Geleophysic and acromicric dysplasias: natural history, genotype-phenotype correlations, and management guidelines from 38 cases.	Genet Med	2021	https://conductscience.org/library/papers/33082559	PubMed
8	3,536,967	Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils.	J Cell Biol	1986	https://conductscience.org/library/papers/3536967	PubMed
9	23,104,886	STAR: ultrafast universal RNA-seq aligner.	Bioinformatics	2013	https://conductscience.org/library/papers/23104886	PubMed
10	6,507,495	Geleophysic dysplasia.	Am J Med Genet	1984	https://conductscience.org/library/papers/6507495	PubMed

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Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 0 citations.

None in this release.

Genes5

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
ADAMTSL2	9,719	PubTator's text mining	https://conductscience.org/library/genes/9719	NCBI Gene
FBN1	2,200	PubTator's text mining	https://conductscience.org/library/genes/2200	NCBI Gene
GRDX	117,189	PubTator's text mining	https://conductscience.org/library/genes/117189	NCBI Gene
LTBP3	4,054	PubTator's text mining	https://conductscience.org/library/genes/4054	NCBI Gene
TGFB1	7,040	PubTator's text mining	https://conductscience.org/library/genes/7040	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bank	Accession
GEO	GSE292600

Source GEO

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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