ConductScience.org, home
Papers
API referenceFor AI assistants

Paper · 4331561

Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity.

Freychet P and 2 others. Proc Natl Acad Sci U S A, 1971. Cited by 597 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Download JSON
Cite this record

ConductScience Library. Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity. Papers, record 4331561. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4331561

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1971
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
597
iCite
Relative citation ratio, by iCite
12.1
iCite
Revised in PubMed
2019-05-01
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Freychet PP
2Roth JJ
3Neville DM JrD M

Source PubMed

Topics23

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Binding SitesMajor topic
Cell MembraneMajor topic
InsulinMajor topic
LiverMajor topic
Receptors, DrugMajor topic
Adipose Tissue
Adrenocorticotropic Hormone
Animals
Cattle
Fishes
Glucagon
Glucose
Growth Hormone
Guinea Pigs
Humans
Iodine Isotopes
Proinsulin
Proteins
Radioimmunoassay
Rats
Swine
Temperature
Time Factors

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References28

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,381,362Effectsof nethalide on insulin activity and binding by rat muscle and adipose tissue.Mol Pharmacol1966https://conductscience.org/library/papers/4381362PubMed
25,257,136Interaction of insulin with the cell membrane: the primary action of insulin.Proc Natl Acad Sci U S A1969https://conductscience.org/library/papers/5257136PubMed
313,728,607The isolation of a cell membrane fraction from rat liver.J Biophys Biochem Cytol1960https://conductscience.org/library/papers/13728607PubMed
44,320,281Characterization of an [125 I]-insulin binding plasma membrane fraction from rat liver.Biochem Biophys Res Commun1970https://conductscience.org/library/papers/4320281PubMed
55,470,386Hormone action at the membrane level. II. The binding of epinephrine and glucagon to the rat liver plasma membrane.Biochim Biophys Acta1970https://conductscience.org/library/papers/5470386PubMed
65,927,116Binding of insulin-131-I by isolated frog sartorius muscles. Relationship to changes in permeability to sugar caused by insulin.J Biol Chem1966https://conductscience.org/library/papers/5927116PubMed
75,842,768[Application of radioisotopes to the study of glucose consumption by the normal rat diaphragm. IV. Relation between tissue binding and the metabolic effect of insulin].Arch Int Pharmacodyn Ther1965https://conductscience.org/library/papers/5842768PubMed
84,310,823Destruction and restoration of the insulin effector system of isolated fat cells.J Biol Chem1969https://conductscience.org/library/papers/4310823PubMed
105,280,527The reaction of glucagon with its receptor: evidence for discrete regions of activity and binding in the glucagon molecule.Proc Natl Acad Sci U S A1971https://conductscience.org/library/papers/5280527PubMed
115,949,593Species variation in the amino acid sequence of insulin.Am J Med1966https://conductscience.org/library/papers/5949593PubMed

1 to 10 of 28

See all 28 references

Cited by119

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 597 citations.

PMIDTitleJournalYearIn PapersSource
40,247,011Insulin resistance in type 2 diabetes mellitus.Nat Rev Endocrinol2025https://conductscience.org/library/papers/40247011PubMed
39,948,335Pancreatic endocrine and exocrine signaling and crosstalk in physiological and pathological status.Signal Transduct Target Ther2025https://conductscience.org/library/papers/39948335PubMed
39,930,003Regulation and function of insulin and insulin-like growth factor receptor signalling.Nat Rev Mol Cell Biol2025https://conductscience.org/library/papers/39930003PubMed
38,963,805A λ-Dynamics Investigation of Insulin Wakayama and Other A3 Variant Binding Affinities to the Insulin Receptor.J Chem Inf Model2024https://conductscience.org/library/papers/38963805PubMed
37,001,136The Activation Mechanism of the Insulin Receptor: A Structural Perspective.Annu Rev Biochem2023https://conductscience.org/library/papers/37001136PubMed
36,473,871The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance.Nat Commun2022https://conductscience.org/library/papers/36473871PubMed
36,244,579The immunomodulatory functions of chromogranin A-derived peptide pancreastatin.Peptides2022https://conductscience.org/library/papers/36244579PubMed
35,874,268Exchange Broadening Underlies the Enhancement of IDE-Dependent Degradation of Insulin by Anionic Membranes.ACS Omega2022https://conductscience.org/library/papers/35874268PubMed
34,912,819Glucose Metabolism in Acute Kidney Injury and Kidney Repair.Front Med (Lausanne)2021https://conductscience.org/library/papers/34912819PubMed
34,841,432Insulin at 100 years - is rebalancing its action key to fighting obesity-related disease?Dis Model Mech2021https://conductscience.org/library/papers/34841432PubMed

1 to 10 of 119

See all 119 cited by

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
GCG2,641PubTator's text mininghttps://conductscience.org/library/genes/2641NCBI Gene
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene
POMC5,443PubTator's text mininghttps://conductscience.org/library/genes/5443NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/4331561

GET https://conductscience.org/api/papers/v1/4331561/references?page=2

API referenceFor AI assistants