Paper · 447806

Diet-induced improvement of abnormalities in insulin and glucagon secretion and in insulin receptor binding in diabetes mellitus.

Savage PJ and 7 others. J Clin Endocrinol Metab, 1979. Cited by 168 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Diet-induced improvement of abnormalities in insulin and glucagon secretion and in insulin receptor binding in diabetes mellitus. Papers, record 447806. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/447806

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Diet-induced improvement of abnormalities in insulin and glucagon secretion and in insulin receptor binding in diabetes mellitus.; PubMed
Journal: J Clin Endocrinol Metab; PubMed
Year: 1979; PubMed
Publication types: Comparative Study, Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/447806/; PubMed
DOI: https://doi.org/10.1210/jcem-48-6-999; PubMed
The journal: https://conductscience.org/library/journal-index/0375362; PubMed
Citations, by iCite: 168; iCite
Relative citation ratio, by iCite: 5.3; iCite
Revised in PubMed: 2018-12-17; PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Savage PJ	P J
2	Bennion LJ	L J
3	Flock EV	E V
4	Nagulesparan M	M
5	Mott D	D
6	Roth J	J
7	Unger RH	R H
8	Bennett PH	P H

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Diabetes Mellitus	Major topic
Diet, Diabetic	Major topic
Glucagon	Major topic
Insulin	Major topic
Receptor, Insulin	Major topic
Adult
Arginine
Blood Glucose
Female
Glucose Tolerance Test
Humans
Insulin Secretion
Kinetics
Male
Middle Aged
Obesity

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by37

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 168 citations.

PMID	Title	Journal	Year	In Papers	Source
40,247,011	Insulin resistance in type 2 diabetes mellitus.	Nat Rev Endocrinol	2025	https://conductscience.org/library/papers/40247011	PubMed
37,524,865	Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes.	Exp Mol Med	2023	https://conductscience.org/library/papers/37524865	PubMed
36,732,513	Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure.	Nat Commun	2023	https://conductscience.org/library/papers/36732513	PubMed
36,636,157	Reflections on the state of diabetes research and prospects for treatment.	Diabetol Int	2023	https://conductscience.org/library/papers/36636157	PubMed
36,432,557	Investigating the Effectiveness of Very Low-Calorie Diets and Low-Fat Vegan Diets on Weight and Glycemic Markers in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.	Nutrients	2022	https://conductscience.org/library/papers/36432557	PubMed
34,907,913	BACH2 inhibition reverses β cell failure in type 2 diabetes models.	J Clin Invest	2021	https://conductscience.org/library/papers/34907913	PubMed
34,207,117	Remission of Type 2 Diabetes with Very Low-Calorie Diets-A Narrative Review.	Nutrients	2021	https://conductscience.org/library/papers/34207117	PubMed
33,427,207	Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes.	JCI Insight	2021	https://conductscience.org/library/papers/33427207	PubMed
31,187,459	Targeting Islets: Metabolic Surgery Is More than a Bariatric Surgery.	Obes Surg	2019	https://conductscience.org/library/papers/31187459	PubMed
30,135,131	Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture.	Diabetes	2018	https://conductscience.org/library/papers/30135131	PubMed

1 to 10 of 37

See all 37 cited by

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
GCG	2,641	PubTator's text mining	https://conductscience.org/library/genes/2641	NCBI Gene
INS	3,630	PubTator's text mining	https://conductscience.org/library/genes/3630	NCBI Gene
INSR	3,643	PubTator's text mining	https://conductscience.org/library/genes/3643	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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