Paper46593
Ir-gene control of immunogenicity of insulin and A-chain loop as a carrier determinant.
Keck K. Nature, 1975. Cited by 148 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. Ir-gene control of immunogenicity of insulin and A-chain loop as a carrier determinant. Papers, record 46593. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/46593
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
Topics20
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Carrier Proteins | Major topic |
| Epitopes | Major topic |
| Genes | Major topic |
| Insulin | Major topic |
| Isoantigens | Major topic |
| Animals | |
| Cattle | |
| Genetic Linkage | |
| Haptens | |
| Histocompatibility Antigens | |
| Lysine | |
| Mice | |
| Mice, Inbred BALB C | |
| Mice, Inbred C57BL | |
| Mice, Inbred Strains | |
| Models, Molecular | |
| Nitrobenzenes | |
| Protein Conformation | |
| Species Specificity | |
| Swine |
Source PubMed
Cited by19
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 148 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 24,507,801 | NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. | Mol Immunol | 2014 | https://conductscience.org/library/papers/24507801 | PubMed |
| 15,181,272 | Qa-1, a nonclassical class I histocompatibility molecule with roles in innate and adaptive immunity. | Immunol Res | 2004 | https://conductscience.org/library/papers/15181272 | PubMed |
| 11,943,868 | Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. | Proc Natl Acad Sci U S A | 2002 | https://conductscience.org/library/papers/11943868 | PubMed |
| 9,730,897 | Transporters associated with antigen processing (TAP)-independent presentation of soluble insulin to alpha/beta T cells by the class Ib gene product, Qa-1(b). | J Exp Med | 1998 | https://conductscience.org/library/papers/9730897 | PubMed |
| 7,895,946 | The potential immunogenicity of human insulin and insulin analogues evaluated in a transgenic mouse model. | Diabetologia | 1994 | https://conductscience.org/library/papers/7895946 | PubMed |
| 6,411,767 | In vitro lymphocyte proliferation response to therapeutic insulin components. Evidence for genetic control by the human major histocompatibility complex. | J Clin Invest | 1983 | https://conductscience.org/library/papers/6411767 | PubMed |
| 6,402,446 | Thymic reconstitution of H-2-linked T-cell responses to thyroglobulin or insulin. | Immunogenetics | 1983 | https://conductscience.org/library/papers/6402446 | PubMed |
| 6,383,916 | Immunological properties and biological effectiveness of insulin analogues substituted at position B30. | Diabetologia | 1984 | https://conductscience.org/library/papers/6383916 | PubMed |
| 6,350,077 | Insulin antibody determination: theoretical and practical considerations. | Diabetologia | 1983 | https://conductscience.org/library/papers/6350077 | PubMed |
| 6,195,108 | RT1-linked Ir and Is genes control the immune response to bovine insulin in the rat. | Immunogenetics | 1983 | https://conductscience.org/library/papers/6195108 | PubMed |
| 6,190,746 | Structural analysis of insulin determinants seen by T cells directed by H-2 genes. | Immunogenetics | 1983 | https://conductscience.org/library/papers/6190746 | PubMed |
| 6,168,025 | Function of macrophages as antigen presenting cells. | Springer Semin Immunopathol | 1980 | https://conductscience.org/library/papers/6168025 | PubMed |
| 6,160,381 | Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites. | Mol Cell Biochem | 1980 | https://conductscience.org/library/papers/6160381 | PubMed |
| 2,125,293 | MHC (RT1) restriction of the antibody repertoire to infection with the nematode Nippostrongylus brasiliensis in the rat. | Immunology | 1990 | https://conductscience.org/library/papers/2125293 | PubMed |
| 1,675,628 | Genetic control of serum antibody responses of inbred mice to type 1 and type 2 fimbriae from Actinomyces viscosus T14V. | Infect Immun | 1991 | https://conductscience.org/library/papers/1675628 | PubMed |
| 955,337 | Humoral immunodeficiency to bacterial antigens in patients with juvenile onset diabetes mellitus. | Diabetologia | 1976 | https://conductscience.org/library/papers/955337 | PubMed |
| 91,175 | Immune response genes have a variable influence on the selection of antigenic foreign and self determinants of insulin. | Proc Natl Acad Sci U S A | 1979 | https://conductscience.org/library/papers/91175 | PubMed |
| 91,172 | Distinct H-2-linked Ir genes control both antibody and T cell responses to different determinants on the same antigen, myoglobin. | Proc Natl Acad Sci U S A | 1979 | https://conductscience.org/library/papers/91172 | PubMed |
| 60,762 | Determinants of antigenic molecules responsible for genetically controlled regulation of immune responses. | Proc Natl Acad Sci U S A | 1976 | https://conductscience.org/library/papers/60762 | PubMed |
Genes2
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| INS | 3,630 | PubTator's text mining | https://conductscience.org/library/genes/3630 | NCBI Gene |
| INSR | 3,643 | PubTator's text mining | https://conductscience.org/library/genes/3643 | NCBI Gene |
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
None in this release
- Grants
- Trials
- Comments and corrections
- References
- Drugs
- Data
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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