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Paper · 59360

Induction if immunological tolerance to the major antigenic determinant of penicillin: a therapeutic approach to penicillin allergy.

Chiorazzi N and 2 others. Proc Natl Acad Sci U S A, 1976. Cited by 44 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Induction if immunological tolerance to the major antigenic determinant of penicillin: a therapeutic approach to penicillin allergy. Papers, record 59360. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/59360

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Induction if immunological tolerance to the major antigenic determinant of penicillin: a therapeutic approach to penicillin allergy.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1976
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
44
iCite
Relative citation ratio, by iCite
1.57
iCite
Revised in PubMed
2019-05-01
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Chiorazzi NN
2Eshhar ZZ
3Katz DHD H

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Drug HypersensitivityMajor topic
Immune ToleranceMajor topic
PenicillinsMajor topic
Antibody Formation
Epitopes
Glutamates
Haptens
Immunoglobulin G
Immunoglobulin M
Immunotherapy
Lysine

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References37

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
110,167B cell tolerance induced by polymeric antigens. I. Comparison of the dose and epitope density requirements for inactivation of primed and unprimed B cells in vivo.Eur J Immunol1976https://conductscience.org/library/papers/10167PubMed
210,168B cell tolerance induced by polymeric antigens. II. Effects of tolerance on hapten-binding lymphocyte levels in primary and secondary antibody responses.Eur J Immunol1976https://conductscience.org/library/papers/10168PubMed
310,172Role of epitope density in the induction of immunity and tolerance with thymus-independent antigens. I. Studies with 2,4-dinitrophenyl conjugates in vitro.Eur J Immunol1975https://conductscience.org/library/papers/10172PubMed
446,237Carrier-determined tolerance in vitro.J Immunol1975https://conductscience.org/library/papers/46237PubMed
546,255Induction of tolerance to nucleic acid determinants by administration of a complex of nucleoside D-glutamic acid and D-lysine (D-GL).J Immunol1975https://conductscience.org/library/papers/46255PubMed
648,523Inuction of immunological tolerance in immunoglobulin E B lymphocytes in rats.J Allergy Clin Immunol1975https://conductscience.org/library/papers/48523PubMed
751,874Carrier-induced tolerance to nucleic acid antigens.J Immunol1975https://conductscience.org/library/papers/51874PubMed
84,097,264Effect of combinations of inbred strain, antigen, and antigen dose on immune responsiveness and reagin production in the mouse. A potential mouse model for immune aspects of human atopic allergy.Int Arch Allergy Appl Immunol1970https://conductscience.org/library/papers/4097264PubMed
94,115,131Immunity tolerance to a hapten (NIP) coupled to an isologous carrier (mouse gamma globulin).J Exp Med1972https://conductscience.org/library/papers/4115131PubMed
104,117,341Inhibition of secondary anti-hapten responses with the hapten conjugated to type 3 pneumococcal polysaccharide.Eur J Immunol1972https://conductscience.org/library/papers/4117341PubMed

1 to 10 of 37

See all 37 references

Cited by6

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 44 citations.

PMIDTitleJournalYearIn PapersSource
7,275,187Adjuvant and suppressive effects of Grass Conjuvac and other alginate conjugates on IgG and IgE antibody responses in mice.Immunology1981https://conductscience.org/library/papers/7275187PubMed
6,157,701Hapten-specific T-cell unresponsiveness induced bybenzylpenicilloyl autologous gamma globulin conjugates in human lymphocyes in vitro.J Clin Invest1980https://conductscience.org/library/papers/6157701PubMed
2,265,481Can persistent IgE responses be suppressed?Clin Exp Immunol1990https://conductscience.org/library/papers/2265481PubMed
286,326Immunological tolerance to allergenic protein determinants: a therapeutic approach for selective inhibition of IgE antibody production.Proc Natl Acad Sci U S A1979https://conductscience.org/library/papers/286326PubMed
84,043Immunological properties of conjugates of ragweed pollen antigen E with methoxypolyethylene glycol or a copolymer of D-glutamic acid and D-lysine.J Exp Med1979https://conductscience.org/library/papers/84043PubMed
77,751
The use of hapten-polysaccharide conjugates for the induction of B-cell tolerance involving IgE responses. I. Preparation, characterization and specific tolerogenic activity of penicilloy l-substituted levans affecting IgE responses in normal and sensitized mice.
Clin Exp Immunol1978https://conductscience.org/library/papers/77751PubMed

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
IGHE3,497PubTator's text mininghttps://conductscience.org/library/genes/3497

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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