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Paper · 6328014

Cooperative effects between two acyclovir resistance loci in herpes simplex virus.

Darby G and 2 others. J Virol, 1984. Cited by 37 papers, by iCite.

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ConductScience Library. Cooperative effects between two acyclovir resistance loci in herpes simplex virus. Papers, record 6328014. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6328014

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Cooperative effects between two acyclovir resistance loci in herpes simplex virus.
PubMed
Journal
J Virol
PubMed
Year
1984
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
37
iCite
Relative citation ratio, by iCite
1.32
iCite
Revised in PubMed
2020-07-24
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Darby GG
2Churcher MJM J
3Larder BAB A

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AcyclovirMajor topic
DNA, ViralMajor topic
GenesMajor topic
Genes, ViralMajor topic
SimplexvirusMajor topic
Animals
Antiviral Agents
Cell Line
Cricetinae
DNA-Directed DNA Polymerase
Drug Resistance, Microbial
Female
Kidney
Kinetics
Mice
Mice, Inbred BALB C
Thymidine Kinase

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References33

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,290,214Some properties of partially purified mammalian adenosine kinase.J Biol Chem1967https://conductscience.org/library/papers/4290214PubMed
214,166,109MUTANT STRAINS OF HERPES SIMPLEX DEFICIENT IN THYMIDINE KINASE-INDUCING ACTIVITY.Virology1964https://conductscience.org/library/papers/14166109PubMed
3170,376Acute and recurrent infection with herpes simplex virus in the mouse: a model for studying latency and recurrent disease.J Gen Virol1975https://conductscience.org/library/papers/170376PubMed
4172,894Possible peptide chain termination mutants in thymide kinase gene of a mammalian virus, herpes simplex virus.Proc Natl Acad Sci U S A1975https://conductscience.org/library/papers/172894PubMed
5189,089Herpes simplex virus resistance and sensitivity to phosphonoacetic acid.J Virol1977https://conductscience.org/library/papers/189089PubMed
6212,476The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.J Hyg (Lond)1978https://conductscience.org/library/papers/212476PubMed
7214,430Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.J Biol Chem1978https://conductscience.org/library/papers/214430PubMed
8218,201In vitro suppression of UAG and UGA mutants in the thymidine kinase gene of herpes simplex virus.Proc Natl Acad Sci U S A1979https://conductscience.org/library/papers/218201PubMed
9475,360Characteristics of herpesvirus mutants resistant to phosphonoformate and phosphonoacetate.Antimicrob Agents Chemother1979https://conductscience.org/library/papers/475360PubMed
10229,629Herpes simplex virus thymidine kinase expression in infection of the trigeminal ganglion.Virology1979https://conductscience.org/library/papers/229629PubMed

1 to 10 of 33

See all 33 references

Cited by10

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 37 citations.

PMIDTitleJournalYearIn PapersSource
28,320,407Association between sensitivity of viral thymidine kinase-associated acyclovir-resistant herpes simplex virus type 1 and virulence.Virol J2017https://conductscience.org/library/papers/28320407PubMed
24,413,420Roles of conserved residues within the pre-NH2-terminal domain of herpes simplex virus 1 DNA polymerase in replication and latency in mice.J Gen Virol2014https://conductscience.org/library/papers/24413420PubMed
15,827,202Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin.J Virol2005https://conductscience.org/library/papers/15827202PubMed
8,392,322Molecular analysis of a neurovirulent herpes simplex virus type 2 strain with reduced thymidine kinase activity.Arch Virol1993https://conductscience.org/library/papers/8392322PubMed
8,380,452Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS.J Virol1993https://conductscience.org/library/papers/8380452PubMed
3,034,575Related functional domains in virus DNA polymerases.EMBO J1987https://conductscience.org/library/papers/3034575PubMed
3,018,291Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene.J Virol1986https://conductscience.org/library/papers/3018291PubMed
3,015,009Susceptibility to other antiherpes drugs of pathogenic variants of herpes simplex virus selected for resistance to acyclovir.Antimicrob Agents Chemother1986https://conductscience.org/library/papers/3015009PubMed
2,982,032Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.J Virol1985https://conductscience.org/library/papers/2982032PubMed
2,653,790Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.Drugs1989https://conductscience.org/library/papers/2653790PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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