Paper · 7680247
Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology.
Goldman CK and 5 others. Mol Biol Cell, 1993. Cited by 476 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
Cite this record
ConductScience Library. Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Papers, record 7680247. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/7680247
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
Topics14
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Endothelial Growth Factors | Major topic |
| Epidermal Growth Factor | Major topic |
| Glioma | Major topic |
| Lymphokines | Major topic |
| Brain Neoplasms | |
| ErbB Receptors | |
| Glioblastoma | |
| Humans | |
| Immunohistochemistry | |
| Models, Biological | |
| Neovascularization, Pathologic | |
| Tumor Cells, Cultured | |
| Vascular Endothelial Growth Factor A | |
| Vascular Endothelial Growth Factors |
Source PubMed
Grants4
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by | Source |
|---|---|---|---|---|---|
| HL-41180 | NHLBI NIH HHS | United States | R01HL041180 | PubMed and NIH | NIH RePORTER |
| NS31096 | NINDS NIH HHS | United States | P20NS031096 | PubMed and NIH | NIH RePORTER |
| T32NSO7335 | NINDS NIH HHS | United States | PubMed | PubMed | |
| T32NS007335 | NIH | NIH RePORTER |
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References46
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 1,563,013 | Enhancement of epidermal growth factor receptor expression on glioma cells by recombinant tumor necrosis factor alpha. | Cancer Immunol Immunother | 1992 | https://conductscience.org/library/papers/1563013 | PubMed |
| 2 | 1,791,186 | Vascular permeability factor: a unique regulator of blood vessel function. | J Cell Biochem | 1991 | https://conductscience.org/library/papers/1791186 | PubMed |
| 3 | 1,380,254 | The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. | Growth Factors | 1992 | https://conductscience.org/library/papers/1380254 | PubMed |
| 4 | 1,858,538 | Thromboembolic phenomena in neurosurgical patients operated upon for primary and metastatic brain tumors. | Acta Neurochir (Wien) | 1991 | https://conductscience.org/library/papers/1858538 | PubMed |
| 5 | 2,447,755 | Fibrinopeptide A and fibrinogen fragment B beta 15-42 and their relation to the operative trauma and post-operative thromboembolism in neurosurgical patients. | Acta Neurochir (Wien) | 1987 | https://conductscience.org/library/papers/2447755 | PubMed |
| 6 | 3,260,903 | Thrombin and histamine activate phospholipase C in human endothelial cells via a phorbol ester-sensitive pathway. | J Cell Physiol | 1988 | https://conductscience.org/library/papers/3260903 | PubMed |
| 7 | 2,924,726 | The effects of platelet-derived growth factor in cultured microvessel endothelial cells. | Endocrinology | 1989 | https://conductscience.org/library/papers/2924726 | PubMed |
| 8 | 4,313,504 | Long term culture of normal and neoplastic human glia. | Acta Pathol Microbiol Scand | 1968 | https://conductscience.org/library/papers/4313504 | PubMed |
| 9 | 5,077,799 | Anti-angiogenesis: new concept for therapy of solid tumors. | Ann Surg | 1972 | https://conductscience.org/library/papers/5077799 | PubMed |
| 10 | 65,285 | In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. | Exp Cell Res | 1977 | https://conductscience.org/library/papers/65285 | PubMed |
1 to 10 of 46
See all 46 referencesCited by146
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 476 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 40,503,863 | RNF213-Dependent EGFR and HER2 Activation Regulates Specific Downstream Signaling Pathways in Human Cancer Cells. | Genes Cells | 2025 | https://conductscience.org/library/papers/40503863 | PubMed |
| 40,113,719 | The Role of Coagulation-Related Genes in Glioblastoma: A Comprehensive Analysis of the Tumor Microenvironment, Prognosis, and Treatment. | Biochem Genet | 2026 | https://conductscience.org/library/papers/40113719 | PubMed |
| 39,815,040 | Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis. | Discov Oncol | 2025 | https://conductscience.org/library/papers/39815040 | PubMed |
| 39,796,008 | Cannabinoids: Role in Neurological Diseases and Psychiatric Disorders. | Int J Mol Sci | 2024 | https://conductscience.org/library/papers/39796008 | PubMed |
| 39,417,842 | A promise of nose to brain delivery of bevacizumab intranasal sol-gel formulation substantiated in rat C6 glioma model. | Naunyn Schmiedebergs Arch Pharmacol | 2025 | https://conductscience.org/library/papers/39417842 | PubMed |
| 38,352,946 | Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis. | J Pharm Anal | 2024 | https://conductscience.org/library/papers/38352946 | PubMed |
| 37,935,834 | Disease specific urinary biomarkers in the central nervous system. | Sci Rep | 2023 | https://conductscience.org/library/papers/37935834 | PubMed |
| 37,689,596 | Dynamic contrast-enhanced MRI radiomics model predicts epidermal growth factor receptor amplification in glioblastoma, IDH-wildtype. | J Neurooncol | 2023 | https://conductscience.org/library/papers/37689596 | PubMed |
| 36,872,336 | Nomogram prediction for the risk of venous thromboembolism in patients with lung cancer. | Cancer Cell Int | 2023 | https://conductscience.org/library/papers/36872336 | PubMed |
| 36,326,383 | EGFR blocker lapatinib inhibits the synthesis of matrix metalloproteinases from synovial fibroblasts. | Turk J Med Sci | 2022 | https://conductscience.org/library/papers/36326383 | PubMed |
1 to 10 of 146
See all 146 cited byGenes4
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| EGF | 1,950 | PubTator's text mining | https://conductscience.org/library/genes/1950 | NCBI Gene |
| EGFR | 1,956 | PubTator's text mining | https://conductscience.org/library/genes/1956 | NCBI Gene |
| VEGFA | 7,422 | PubTator's text mining | https://conductscience.org/library/genes/7422 | NCBI Gene |
| VWF | 7,450 | PubTator's text mining | https://conductscience.org/library/genes/7450 | NCBI Gene |
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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