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Paper · 783201

Arginine-stimulated acute phase of insulin and glucagon secretion in diabetic subjects.

Palmer JP and 3 others. J Clin Invest, 1976. Cited by 188 papers, by iCite.

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ConductScience Library. Arginine-stimulated acute phase of insulin and glucagon secretion in diabetic subjects. Papers, record 783201. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/783201

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Arginine-stimulated acute phase of insulin and glucagon secretion in diabetic subjects.
PubMed
Journal
J Clin Invest
PubMed
Year
1976
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
188
iCite
Relative citation ratio, by iCite
5.56
iCite
Revised in PubMed
2022-02-24
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Palmer JPJ P
2Benson JWJ W
3Walter RMR M
4Ensinck JWJ W

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
ArginineMajor topic
Diabetes MellitusMajor topic
GlucagonMajor topic
InsulinMajor topic
Adolescent
Adult
Antigens
Diabetes Mellitus, Type 1
Dose-Response Relationship, Drug
Female
Glucose
Humans
Insulin Secretion
Islets of Langerhans
Male
Stimulation, Chemical

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials2

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's recordSource
NCT02684929Effects of Chronic Dietary Exposure to Branched Chain Amino AcidsBackgroundClinicalTrials.gov
NCT02697305Incretin Effects of Branched Chain Amino AcidsBackgroundClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References28

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
15,687,345Early phase of insulin release.Diabetes1968https://conductscience.org/library/papers/5687345PubMed
24,131,886A unifying hypothesis for hereditary and acquired diabetes.Lancet1974https://conductscience.org/library/papers/4131886PubMed
34,153,713The effect of adrenergic blockade on the glucagon responses to starvation and hypoglycemia in man.J Clin Invest1974https://conductscience.org/library/papers/4153713PubMed
44,373,494Glucagon secretion from the perfused rat pancreas. Studies with glucose and catecholamines.J Clin Invest1974https://conductscience.org/library/papers/4373494PubMed
54,581,053Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect.Science1973https://conductscience.org/library/papers/4581053PubMed
64,598,090Clinical control of diabetes by the artificial pancreas.Diabetes1974https://conductscience.org/library/papers/4598090PubMed
74,598,089An artificial endocrine pancreas.Diabetes1974https://conductscience.org/library/papers/4598089PubMed
84,555,783Acute and steady-state insulin responses to glucose in nonobese diabetic subjects.J Clin Invest1972https://conductscience.org/library/papers/4555783PubMed
94,552,828Decreased sensitivity of the pancreatic beta cells to glucose in prediabetic and diabetic subjects. A glucose dose-response study.Diabetes1972https://conductscience.org/library/papers/4552828PubMed
104,438,348Concentrations of glucagon and the insulin:glucagon ratio in the portal and peripheral circulation.Proc Soc Exp Biol Med1974https://conductscience.org/library/papers/4438348PubMed

1 to 10 of 28

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Cited by42

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 188 citations.

PMIDTitleJournalYearIn PapersSource
42,595,807
Diminished arginine bioavailability during hyperglycaemia distinguishes individuals with A-β+ ketosis-prone diabetes from those with type 2 diabetes: implications for the pathogenesis of ketoacidosis in A-β+ ketosis-prone diabetes.
Diabetologia2026https://conductscience.org/library/papers/42595807PubMed
41,644,541Development of a severe rat refeeding syndrome model and mathematical modeling of the associated hypophosphatemia.NPJ Syst Biol Appl2026https://conductscience.org/library/papers/41644541PubMed
37,512,487Low Fasting Concentrations of Glucagon in Patients with Very Long-Chain Acyl-CoA Dehydrogenase Deficiency.Metabolites2023https://conductscience.org/library/papers/37512487PubMed
37,166,980Short-term fasting lowers glucagon levels under euglycemic and hypoglycemic conditions in healthy humans.JCI Insight2023https://conductscience.org/library/papers/37166980PubMed
36,187,117Mathematical model of insulin kinetics accounting for the amino acids effect during a mixed meal tolerance test.Front Endocrinol (Lausanne)2022https://conductscience.org/library/papers/36187117PubMed
35,657,690Cross Talk Between Insulin and Glucagon Receptor Signaling in the Hepatocyte.Diabetes2022https://conductscience.org/library/papers/35657690PubMed
35,399,942A Hypothesis From Metabolomics Analysis of Diabetic Retinopathy: Arginine-Creatine Metabolic Pathway May Be a New Treatment Strategy for Diabetic Retinopathy.Front Endocrinol (Lausanne)2022https://conductscience.org/library/papers/35399942PubMed
34,999,111Insulin regulates arginine-stimulated insulin secretion in humans.Metabolism2022https://conductscience.org/library/papers/34999111PubMed
34,203,642Egg White Protein Feeding Facilitates Skeletal Muscle Gain in Young Rats with/without Clenbuterol Treatment.Nutrients2021https://conductscience.org/library/papers/34203642PubMed
34,003,799C-peptide enhances glucagon secretion in response to hyperinsulinemia under euglycemic and hypoglycemic conditions.JCI Insight2021https://conductscience.org/library/papers/34003799PubMed

1 to 10 of 42

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Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
GCG2,641PubTator's text mininghttps://conductscience.org/library/genes/2641NCBI Gene
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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