Paper · 8104780

1,25-Dihydroxycholecalciferol rapidly activates rat colonic particulate guanylate cyclase via a protein kinase C-dependent mechanism.

Khare S and 6 others. Endocrinology, 1993. Cited by 21 papers, by iCite.

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ConductScience Library. 1,25-Dihydroxycholecalciferol rapidly activates rat colonic particulate guanylate cyclase via a protein kinase C-dependent mechanism. Papers, record 8104780. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8104780

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: 1,25-Dihydroxycholecalciferol rapidly activates rat colonic particulate guanylate cyclase via a protein kinase C-dependent mechanism.; PubMed
Journal: Endocrinology; PubMed
Year: 1993; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/8104780/; PubMed
DOI: https://doi.org/10.1210/endo.133.5.8104780; PubMed
The journal: https://conductscience.org/library/journal-index/0375040; PubMed
Citations, by iCite: 21; iCite
Relative citation ratio, by iCite: 0.49; iCite
Revised in PubMed: 2015-11-19; PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Khare S	S
2	Wilson DM	D M
3	Tien XY	X Y
4	Dudeja PK	P K
5	Wali RK	R K
6	Sitrin MD	M D
7	Brasitus TA	T A

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Calcitriol	Major topic
Colon	Major topic
Guanylate Cyclase	Major topic
Protein Kinase C	Major topic
Adenylyl Cyclases
Alkaloids
Animals
Cell Membrane
Enzyme Activation
Estrenes
Kinetics
Male
Pyrrolidinones
Rats
Rats, Sprague-Dawley
Staurosporine
Tetradecanoylphorbol Acetate
Type C Phospholipases

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
DK-39573	NIDDK NIH HHS	United States	R01DK039573	PubMed and NIH	NIH RePORTER
P30-DK26687	NIDDK NIH HHS	United States	P30DK026687	PubMed and NIH	NIH RePORTER
P30-DK42086	NIDDK NIH HHS	United States	P30DK042086	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by5

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 21 citations.

PMID	Title	Journal	Year	In Papers	Source
36,384,366	Sprouty4 is epigenetically upregulated in human colorectal cancer.	Epigenetics	2023	https://conductscience.org/library/papers/36384366	PubMed
34,685,612	Epigenetic DNA Modifications Upregulate SPRY2 in Human Colorectal Cancers.	Cells	2021	https://conductscience.org/library/papers/34685612	PubMed
32,110,952	Enhanced CXCR4 Expression Associates with Increased Gene Body 5-Hydroxymethylcytosine Modification but not Decreased Promoter Methylation in Colorectal Cancer.	Cancers (Basel)	2020	https://conductscience.org/library/papers/32110952	PubMed
8,979,259	Phosphorylation and activation of the intestinal guanylyl cyclase receptor for Escherichia coli heat-stable toxin by protein kinase C.	Mol Cell Biochem	1996	https://conductscience.org/library/papers/8979259	PubMed
7,738,187	1,25-Dihydroxyvitamin D3 and 12-O-tetradecanoyl phorbol 13-acetate cause differential activation of Ca(2+)-dependent and Ca(2+)-independent isoforms of protein kinase C in rat colonocytes.	J Clin Invest	1995	https://conductscience.org/library/papers/7738187	PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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