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Paper · 36384366

Sprouty4 is epigenetically upregulated in human colorectal cancer.

Stuckel AJ and 11 others. Epigenetics, 2023. Cited by 4 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Sprouty4 is epigenetically upregulated in human colorectal cancer. Papers, record 36384366. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/36384366

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Sprouty4 is epigenetically upregulated in human colorectal cancer.
PubMed
Journal
Epigenetics
PubMed
Year
2023
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
4
iCite
Relative citation ratio, by iCite
0.39
iCite
Revised in PubMed
2026-03-31
PubMed

Authors12

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Stuckel AJAlexei J
2Zeng SShuai
3Lyu ZZhen
4Zhang WWei
5Zhang XXu
6Dougherty UUrszula
7Mustafi RReba
8Khare TTripti
9Zhang QQiong
10Joshi TTrupti

1 to 10 of 12Source PubMed

See all 12 authors

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Colorectal NeoplasmsMajor topic
DNA MethylationMajor topic
Humans
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
RNA, Messenger
Nerve Tissue Proteins
Intracellular Signaling Peptides and Proteins

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
I01 BX000824BLRD VAUnited StatesI01BX000824PubMedNIH RePORTER
R01 CA240710NCI NIH HHSUnited StatesR01CA240710PubMed and NIHNIH RePORTER
R03 CA249487NCI NIH HHSUnited StatesR03CA249487PubMedNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References47

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
128,925,3865-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers.Cell Res2017https://conductscience.org/library/papers/28925386PubMed
228,732,181IRF6 and SPRY4 Signaling Interact in Periderm Development.J Dent Res2017https://conductscience.org/library/papers/28732181PubMed
326,973,433Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells.Cancer Cell Int2016https://conductscience.org/library/papers/26973433PubMed
433,906,393Identification of SPRY4 as a Novel Candidate Susceptibility Gene for Familial Nonmedullary Thyroid Cancer.Thyroid2021https://conductscience.org/library/papers/33906393PubMed
516,388,505Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer.Prostate2006https://conductscience.org/library/papers/16388505PubMed
624,811,094SPRY4-mediated ERK1/2 signaling inhibition abolishes 17β-estradiol-induced cell growth in endometrial adenocarcinoma cell.Gynecol Endocrinol2014https://conductscience.org/library/papers/24811094PubMed
730,390,072Oncogenic microRNA-411 promotes lung carcinogenesis by directly targeting suppressor genes SPRY4 and TXNIP.Oncogene2019https://conductscience.org/library/papers/30390072PubMed
88,104,7801,25-Dihydroxycholecalciferol rapidly activates rat colonic particulate guanylate cyclase via a protein kinase C-dependent mechanism.Endocrinology1993https://conductscience.org/library/papers/8104780PubMed
933,879,635SPRY4 suppresses proliferation and induces apoptosis of colorectal cancer cells by repressing oncogene EZH2.Aging (Albany NY)2021https://conductscience.org/library/papers/33879635PubMed
1033,670,044A Sprouty4 Mutation Identified in Kallmann Syndrome Increases the Inhibitory Potency of the Protein towards FGF and Connected Processes.Int J Mol Sci2021https://conductscience.org/library/papers/33670044PubMed

1 to 10 of 47

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Cited by4

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 4 citations.

PMIDTitleJournalYearIn PapersSource
39,393,0345-Hydroxymethylated Biomarkers in Cell-Free DNA Predict Occult Colorectal Cancer up to 36 Months Before Diagnosis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.JCO Precis Oncol2024https://conductscience.org/library/papers/39393034PubMed
38,686,189Role of SPRY4 in health and disease.Front Oncol2024https://conductscience.org/library/papers/38686189PubMed
37,021,228Sprouty 4 expression in human oral squamous cell carcinogenesis.J Dent Sci2023https://conductscience.org/library/papers/37021228PubMed
36,672,310Epigenetics of Thymic Epithelial Tumors.Cancers (Basel)2023https://conductscience.org/library/papers/36672310PubMed

Genes14

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CTCF10,664PubTator's text mininghttps://conductscience.org/library/genes/10664NCBI Gene
CXCR47,852PubTator's text mininghttps://conductscience.org/library/genes/7852NCBI Gene
ETS12,113PubTator's text mininghttps://conductscience.org/library/genes/2113NCBI Gene
F32,152PubTator's text mininghttps://conductscience.org/library/genes/2152NCBI Gene
HDAC49,759PubTator's text mininghttps://conductscience.org/library/genes/9759NCBI Gene
MIR1908100,302,263PubTator's text mininghttps://conductscience.org/library/genes/100302263NCBI Gene
MIR411693,121PubTator's text mininghttps://conductscience.org/library/genes/693121NCBI Gene
MMP24,313PubTator's text mininghttps://conductscience.org/library/genes/4313NCBI Gene
PPARG5,468PubTator's text mininghttps://conductscience.org/library/genes/5468NCBI Gene
RAC15,879PubTator's text mininghttps://conductscience.org/library/genes/5879NCBI Gene

1 to 10 of 14

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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