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Paper · 33879635

SPRY4 suppresses proliferation and induces apoptosis of colorectal cancer cells by repressing oncogene EZH2.

Guo J and 5 others. Aging (Albany NY), 2021. Cited by 13 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. SPRY4 suppresses proliferation and induces apoptosis of colorectal cancer cells by repressing oncogene EZH2. Papers, record 33879635. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/33879635

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
SPRY4 suppresses proliferation and induces apoptosis of colorectal cancer cells by repressing oncogene EZH2.
PubMed
Journal
Aging (Albany NY)
PubMed
Year
2021
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
13
iCite
Relative citation ratio, by iCite
0.83
iCite
Revised in PubMed
2021-07-26
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Guo JJia
2Zhu HHuadong
3Li QQiang
4Dong JJianhua
5Xiong WWei
6Yu KKun

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Colorectal NeoplasmsMajor topic
Enhancer of Zeste Homolog 2 ProteinMajor topic
Gene Expression Regulation, NeoplasticMajor topic
Intracellular Signaling Peptides and ProteinsMajor topic
Nerve Tissue ProteinsMajor topic
Animals
Apoptosis
Cell Line, Tumor
Cell Movement
Cell Proliferation
Gene Knockdown Techniques
Humans
Indoles
Male
Mice
Neoplasm Invasiveness
Pyridones
Xenograft Model Antitumor Assays

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References34

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
116,729,025Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities.Cell Death Differ2006https://conductscience.org/library/papers/16729025PubMed
230,387,828UBA2 promotes proliferation of colorectal cancer.Mol Med Rep2018https://conductscience.org/library/papers/30387828PubMed
325,220,842Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.Int J Cancer2015https://conductscience.org/library/papers/25220842PubMed
416,337,795Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling.Trends Cell Biol2006https://conductscience.org/library/papers/16337795PubMed
529,540,569An EZH2-mediated epigenetic mechanism behind p53-dependent tissue sensitivity to DNA damage.Proc Natl Acad Sci U S A2018https://conductscience.org/library/papers/29540569PubMed
626,973,433Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells.Cancer Cell Int2016https://conductscience.org/library/papers/26973433PubMed
727,899,259Overexpression of the long non-coding RNA SPRY4-IT1 promotes tumor cell proliferation and invasion by activating EZH2 in hepatocellular carcinoma.Biomed Pharmacother2017https://conductscience.org/library/papers/27899259PubMed
816,388,505Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer.Prostate2006https://conductscience.org/library/papers/16388505PubMed
926,768,617Sprouty4 mediates amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells.Tumour Biol2016https://conductscience.org/library/papers/26768617PubMed
109,458,049sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.Cell1998https://conductscience.org/library/papers/9458049PubMed

1 to 10 of 34

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Cited by7

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 13 citations.

PMIDTitleJournalYearIn PapersSource
40,835,851Expression profiles of miR-411 and SPRY4 as indicators of disease progression and treatment in chronic myelogenous leukemia.Sci Rep2025https://conductscience.org/library/papers/40835851PubMed
40,806,483The Lysine at Position 177 Is Essential to Limit the Inhibitory Capacities of Sprouty4 Protein in Normal and Cancer-Derived Cells.Int J Mol Sci2025https://conductscience.org/library/papers/40806483PubMed
39,164,253Mdm2 requires Sprouty4 to regulate focal adhesion formation and metastasis independent of p53.Nat Commun2024https://conductscience.org/library/papers/39164253PubMed
38,686,189Role of SPRY4 in health and disease.Front Oncol2024https://conductscience.org/library/papers/38686189PubMed
37,889,057SUV39H1 Expression as a Guideline for Omitting Radiotherapy in Lymph Node-positive Triple-negative Breast Cancer Patients.Cancer Genomics Proteomics2023https://conductscience.org/library/papers/37889057PubMed
36,915,750Long noncoding RNA SPRY4-IT1 acts as a miR-101-5p sponge to promote gastrointestinal stromal tumor progression by inhibiting ZEB1.Am J Transl Res2023https://conductscience.org/library/papers/36915750PubMed
36,384,366Sprouty4 is epigenetically upregulated in human colorectal cancer.Epigenetics2023https://conductscience.org/library/papers/36384366PubMed

Genes12

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
BAX581PubTator's text mininghttps://conductscience.org/library/genes/581NCBI Gene
BCL2596PubTator's text mininghttps://conductscience.org/library/genes/596NCBI Gene
CASP3836PubTator's text mininghttps://conductscience.org/library/genes/836NCBI Gene
CYCS54,205PubTator's text mininghttps://conductscience.org/library/genes/54205NCBI Gene
EZH22,146PubTator's text mininghttps://conductscience.org/library/genes/2146NCBI Gene
MDM24,193PubTator's text mininghttps://conductscience.org/library/genes/4193NCBI Gene
MMP24,313PubTator's text mininghttps://conductscience.org/library/genes/4313NCBI Gene
MMP94,318PubTator's text mininghttps://conductscience.org/library/genes/4318NCBI Gene
POTEF728,378PubTator's text mininghttps://conductscience.org/library/genes/728378NCBI Gene
SPRY481,848PubTator's text mininghttps://conductscience.org/library/genes/81848NCBI Gene

1 to 10 of 12

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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