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Paper · 32110952

Enhanced CXCR4 Expression Associates with Increased Gene Body 5-Hydroxymethylcytosine Modification but not Decreased Promoter Methylation in Colorectal Cancer.

Stuckel AJ and 12 others. Cancers (Basel), 2020. Cited by 14 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Enhanced CXCR4 Expression Associates with Increased Gene Body 5-Hydroxymethylcytosine Modification but not Decreased Promoter Methylation in Colorectal Cancer. Papers, record 32110952. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/32110952

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Enhanced CXCR4 Expression Associates with Increased Gene Body 5-Hydroxymethylcytosine Modification but not Decreased Promoter Methylation in Colorectal Cancer.
PubMed
Journal
Cancers (Basel)
PubMed
Year
2020
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
14
iCite
Relative citation ratio, by iCite
0.56
iCite
Revised in PubMed
2021-09-08
PubMed

Authors13

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Stuckel AJAlexei J
2Zhang WWei
3Zhang XXu
4Zeng SShuai
5Dougherty UUrszula
6Mustafi RReba
7Zhang QQiong
8Perreand EElsa
9Khare TTripti
10Joshi TTrupti

1 to 10 of 13Source PubMed

See all 13 authors

Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants6

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
1R01CA240710NCI NIH HHSUnited StatesR01CA240710PubMed and NIHNIH RePORTER
1RO3CA216160-01NCI NIH HHSUnited StatesRO3CA216160PubMedNIH RePORTER
2I01BX000824-05A2Veterans AffairsI01BX000824PubMedNIH RePORTER
R01 CA240710NCI NIH HHSUnited StatesR01CA240710PubMed and NIHNIH RePORTER
U01 CA217078NCI NIH HHSUnited StatesU01CA217078PubMed and NIHNIH RePORTER
R03CA216160NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Erratum in33,114,273
Correction: Stuckel, et al.; Enhanced CXCR4 Expression Associates with Increased Gene Body 5-Hydroxymethylcytosine Modification but Not Decreased Promoter Methylation in Colorectal Cancer. Cancers 2020, 12, 539.
https://conductscience.org/library/papers/33114273

Source PubMed

References77

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
130,792,573Correlation Patterns Between DNA Methylation and Gene Expression in The Cancer Genome Atlas.Cancer Inform2019https://conductscience.org/library/papers/30792573PubMed
229,491,831Species-Specific 5 mC and 5 hmC Genomic Landscapes Indicate Epigenetic Contribution to Human Brain Evolution.Front Mol Neurosci2018https://conductscience.org/library/papers/29491831PubMed
318,664,506The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia.Gut2008https://conductscience.org/library/papers/18664506PubMed
424,590,865Breast cancer nodal metastasis correlates with tumour and lymph node methylation profiles of Caveolin-1 and CXCR4.Clin Exp Metastasis2014https://conductscience.org/library/papers/24590865PubMed
523,193,274ENCODE data in the UCSC Genome Browser: year 5 update.Nucleic Acids Res2013https://conductscience.org/library/papers/23193274PubMed
68,331,684Increased cytosine DNA-methyltransferase activity during colon cancer progression.J Natl Cancer Inst1993https://conductscience.org/library/papers/8331684PubMed
712,384,559Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer.Cancer Res2002https://conductscience.org/library/papers/12384559PubMed
810,656,438Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma.Clin Cancer Res2000https://conductscience.org/library/papers/10656438PubMed
928,925,3865-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers.Cell Res2017https://conductscience.org/library/papers/28925386PubMed
108,012,390Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation.Nat Genet1994https://conductscience.org/library/papers/8012390PubMed

1 to 10 of 77

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Cited by11

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 14 citations.

PMIDTitleJournalYearIn PapersSource
39,393,0345-Hydroxymethylated Biomarkers in Cell-Free DNA Predict Occult Colorectal Cancer up to 36 Months Before Diagnosis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.JCO Precis Oncol2024https://conductscience.org/library/papers/39393034PubMed
38,464,391DNA methylation modulates epigenetic regulation in colorectal cancer diagnosis, prognosis and precision medicine.Explor Target Antitumor Ther2024https://conductscience.org/library/papers/38464391PubMed
37,198,402New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine.Cell Mol Immunol2023https://conductscience.org/library/papers/37198402PubMed
37,190,171Epigenetic Modifications in Prostate Cancer Metastasis and Microenvironment.Cancers (Basel)2023https://conductscience.org/library/papers/37190171PubMed
36,384,366Sprouty4 is epigenetically upregulated in human colorectal cancer.Epigenetics2023https://conductscience.org/library/papers/36384366PubMed
35,573,225Toxicity Profiling of Bacterial Inclusion Bodies in Human Caco-2 Cells.Front Bioeng Biotechnol2022https://conductscience.org/library/papers/35573225PubMed
35,406,582Colorectal Cancer: The Contribution of CXCL12 and Its Receptors CXCR4 and CXCR7.Cancers (Basel)2022https://conductscience.org/library/papers/35406582PubMed
35,070,954CXCR4 Mediates Enhanced Cell Migration in CALM-AF10 Leukemia.Front Oncol2021https://conductscience.org/library/papers/35070954PubMed
34,298,991CXCL12-CXCR4/CXCR7 Axis in Colorectal Cancer: Therapeutic Target in Preclinical and Clinical Studies.Int J Mol Sci2021https://conductscience.org/library/papers/34298991PubMed
33,552,263Comprehensive analysis of lncRNA-associated ceRNA network reveals the novel potential of lncRNA, miRNA and mRNA biomarkers in human rectosigmoid junction cancer.Oncol Lett2021https://conductscience.org/library/papers/33552263PubMed

1 to 10 of 11

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Genes9

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CXCL126,387PubTator's text mininghttps://conductscience.org/library/genes/6387NCBI Gene
CXCR47,852PubTator's text mininghttps://conductscience.org/library/genes/7852NCBI Gene
DNMT11,786PubTator's text mininghttps://conductscience.org/library/genes/1786NCBI Gene
DNMT3B1,789PubTator's text mininghttps://conductscience.org/library/genes/1789NCBI Gene
KRT2054,474PubTator's text mininghttps://conductscience.org/library/genes/54474NCBI Gene
NRF14,899PubTator's text mininghttps://conductscience.org/library/genes/4899NCBI Gene
POTEF728,378PubTator's text mininghttps://conductscience.org/library/genes/728378NCBI Gene
VHL7,428PubTator's text mininghttps://conductscience.org/library/genes/7428NCBI Gene
VIM7,431PubTator's text mininghttps://conductscience.org/library/genes/7431NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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