Trial · NCT02876757
5 Alpha Reductase Inhibitors And The Risk Of Suicide And Depression
NCT02876757, Completed, London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's; results first posted 2018-02-05
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. 5 Alpha Reductase Inhibitors And The Risk Of Suicide And Depression. Trials, record NCT02876757. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02876757
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- 5 Alpha Reductase Inhibitors And The Risk Of Suicide And Depression
- NCT number
- NCT02876757
- Status
- Completed
- Enrollment
- 186,394 participants, actual
- Lead sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
- Conditions
- BPH, Depression, Suicide
- Interventions
- 5ARI
- First posted
- 2016-08-24
- Last updated
- 2024-01-12
- Results first posted
- 2018-02-05
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Suicide (Based on Administrative Data Elements From Ontario Registrar General Death Database, National Ambulatory Care Reporting System, Hospital Discharge Abstracts, and Ontario Regional Mental Health Database) | Through study completition, an average of 18 months. | 1. Ontario Registrar General Death database. Use the COD\_primary variable (used from 2003 onwards) to define suicide, based on an ICD10 code of X60-X84. 2. NACRS: X60-84 (dx10code1-dx10code10) AND dead on arrival or death after arrival (visdisp2002 = 10 or 11). Consider admission date the date of the event. 3. OMHRS: Discharge reason (dischreason (X90) = 2). Died from suicide. Consider admission date the date of the event. 4. CIHI-DAD (Consider admission date the date of the event): i. suicide=1, or ii. dx10code1-25= ICD10 X60-84 AND dischdisp="07". |
| Secondary | Suicide Attempt (Based on Administrative Data Elements From National Ambulatory Care Reporting System, and Ontario Regional Mental Health Database) | Through study completition, an average of 18 months. | 1. NACRS: presentation to the emergency room: ICD 10 codes X60-X84 (intentional self harm). 2. OMHRS: admission with suicide ideation. i. Self injury attempts: D1A or selfinjury\_attempt=3, 4, 5, or 6 ii. Self injury intent: D1B or selfinjury\_intent=1 iii. Self injury considered: D1C or selfinjury\_cons=3, 4, 5 or 6 iv. Self injury plan: D1DB or suicide\_plan=1 |
| Secondary | Depression (Based on Administrative Data Elements From Hospital Discharge Abstract Database, and Ontario Regional Mental Health Database and Ontario Health Insurance Plan) | Through study completition, an average of 18 months. | 1. Any CIHI-DAD/SDS ICD 10 code, OR 2. Any OMRHS code Axis1\_dsm4code1-19 or Axis2\_dsm4code 1-7 OR 3. Look for any OHIP record billed by Mainspecialty = "PSYCHIATRY" with a diagnosis of depression OHIP dxcode 311, OR 4. ≥2 GP visits within 2 years AND both with OHIP dxcode 311 i. OHIP dxcode: 311 ii. ICD 10: F32.0, F32.1, F32.2, F32.3, F32.8, F32.9, F33.0, F33.1, F33.2, F33.3, F33.4, F33.8, F34.1 iii. Psychiatry visits defined as any of these OHIP fee codes: A195, A895, A190, A795, A695, A395, A196, A193, A194, A191, A192 iv. OMHRS: 29620-29626, 29630-29636, 31100 (major depressive disorder) |
Source ClinicalTrials.gov
Outcomes3
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Suicide (Based on Administrative Data Elements From Ontario Registrar General Death Database, National Ambulatory Care Reporting System, Hospital Discharge Abstracts, and Ontario Regional Mental Health Database) | Through study completition, an average of 18 months. | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Suicide Attempt (Based on Administrative Data Elements From National Ambulatory Care Reporting System, and Ontario Regional Mental Health Database) | Through study completition, an average of 18 months. | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Depression (Based on Administrative Data Elements From Hospital Discharge Abstract Database, and Ontario Regional Mental Health Database and Ontario Health Insurance Plan) | Through study completition, an average of 18 months. | This population is restricted to those who had no history of depression, thus it is a subgroup of the total study population. | Participants | COUNT_OF_PARTICIPANTS |
Source ClinicalTrials.gov
Results by group6
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
Suicide (Based on Administrative Data Elements From Ontario Registrar General Death Database, National Ambulatory Care Reporting System, Hospital Discharge Abstracts, and Ontario Regional Mental Health Database) | 5ARI Users | 38 | Participants | ||
Suicide (Based on Administrative Data Elements From Ontario Registrar General Death Database, National Ambulatory Care Reporting System, Hospital Discharge Abstracts, and Ontario Regional Mental Health Database) | Non 5ARI Users | 36 | Participants | ||
| Suicide Attempt (Based on Administrative Data Elements From National Ambulatory Care Reporting System, and Ontario Regional Mental Health Database) | 5ARI Users | 169 | Participants | ||
| Suicide Attempt (Based on Administrative Data Elements From National Ambulatory Care Reporting System, and Ontario Regional Mental Health Database) | Non 5ARI Users | 130 | Participants | ||
| Depression (Based on Administrative Data Elements From Hospital Discharge Abstract Database, and Ontario Regional Mental Health Database and Ontario Health Insurance Plan) | 5ARI Users | 1750 | Participants | ||
| Depression (Based on Administrative Data Elements From Hospital Discharge Abstract Database, and Ontario Regional Mental Health Database and Ontario Health Insurance Plan) | Non 5ARI Users | 1231 | Participants |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | 5ARI Users | 93,197 | |
| Overall Study | STARTED | Non 5ARI Users | 93,197 | |
| Overall Study | COMPLETED | 5ARI Users | 93,197 | |
| Overall Study | COMPLETED | Non 5ARI Users | 93,197 | |
| Overall Study | NOT COMPLETED | 5ARI Users | 0 | |
| Overall Study | NOT COMPLETED | Non 5ARI Users | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | 5ARI Users | 160 | 93,197 |
| Total, all-cause mortality | Non 5ARI Users | 139 | 93,197 |
| Total, other adverse events | 5ARI Users | 0 | 93,197 |
| Total, other adverse events | Non 5ARI Users | 0 | 93,197 |
| Total, serious adverse events | 5ARI Users | 0 | 93,197 |
| Total, serious adverse events | Non 5ARI Users | 0 | 93,197 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons5
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
5ARI Users vs Non 5ARI Users: Suicide (Based on Administrative Data Elements From Ontario Registrar General Death Database, National Ambulatory Care Reporting System, Hospital Discharge Abstracts, and Ontario Regional Mental Health Database) | Trial comparisons |
5ARI Users vs Non 5ARI Users: Depression (Based on Administrative Data Elements From Hospital Discharge Abstract Database, and Ontario Regional Mental Health Database and Ontario Health Insurance Plan) | Trial comparisons |
| 5ARI Users vs Non 5ARI Users: deaths from any cause | Trial comparisons |
| 5ARI Users vs Non 5ARI Users: Suicide Attempt (Based on Administrative Data Elements From National Ambulatory Care Reporting System, and Ontario Regional Mental Health Database) | Trial comparisons |
| 5ARI Users vs Non 5ARI Users: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02876757
GET https://conductscience.org/api/trials/v1/NCT02876757/registered