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85,013 comparisons from ClinicalTrials.gov.

85,013 comparisons

Most participants first33,758 with no events in either group come last2,581 to 2,600 of 85,013

Show the results as
ComparisonWith the outcomeRisk difference, 95% intervalParticipantsTrial
Anastrozole vs Tamoxifen: serious adverse events333 of 1,449

371 of 1,489

-1.9 points

-5.0 to 1.2

2,938NCT00072462

Adjuvant Tamoxifen Compared With Anastrozole in Treating Postmenopausal Women With Ductal Carcinoma In Situ

Conceptrol vs Amphora: serious adverse events19 of 1,477

11 of 1,458

0.5 points

-0.2 to 1.3

2,935NCT01306331

Study of Contraceptive Efficacy & Safety of Phexxi™ (Previously Known as Amphora) Gel Compared to Conceptrol Vaginal Gel

Standard RRT Initiation vs Accelerated RRT Initiation: All-cause Mortality.639 of 1,462

643 of 1,465

-0.2 points

-3.8 to 3.4

2,927NCT02568722

Standard vs. Accelerated Initiation of RRT in Acute Kidney Injury (STARRT-AKI: Principal Trial)

Standard RRT Initiation vs Accelerated RRT Initiation: deaths from any cause639 of 1,462

643 of 1,465

-0.2 points

-3.8 to 3.4

2,927NCT02568722

Standard vs. Accelerated Initiation of RRT in Acute Kidney Injury (STARRT-AKI: Principal Trial)

Contact Tracing Household-based Sub-arm vs Contact Tracing Incentive-based Sub-arm: Comparative Treatment Initiation Ratio in the Incentive-based Versus Household-based Contact Investigation Arms1,413 of 1,413

1,510 of 1,510

0.0 points

-0.3 to 0.3

2,923NCT02808507

Comparative Effectiveness/Implementation of TB Case Finding in Rural South Africa

Contact Tracing Household-based Sub-arm vs Contact Tracing Incentive-based Sub-arm: Comparative Number of Secondary TB Cases Identified in Incentive-based Versus Household-based Contact Tracing17 of 1,413

17 of 1,510

0.1 points

-0.7 to 0.9

2,923NCT02808507

Comparative Effectiveness/Implementation of TB Case Finding in Rural South Africa

Patient Self-Testing (PST) vs High Quality Anticoagulation Management (HQACM): serious adverse events247 of 1,465

250 of 1,457

-0.3 points

-3.0 to 2.4

2,922NCT00032591

The Home INR Study

Otilimab 90 mg vs Otilimab 150 mg: Number of Participants With Anti-GSK3196165 Antibodies11 of 1,456

10 of 1,459

0.1 points

-0.6 to 0.7

2,915NCT04333147

Long-term Safety and Efficacy of GSK3196165 (Otilimab) in the Treatment of Rheumatoid Arthritis (RA)

Otilimab 90 mg vs Otilimab 150 mg: deaths from any cause10 of 1,456

9 of 1,459

0.1 points

-0.6 to 0.7

2,915NCT04333147

Long-term Safety and Efficacy of GSK3196165 (Otilimab) in the Treatment of Rheumatoid Arthritis (RA)

Otilimab 90 mg vs Otilimab 150 mg: serious adverse events123 of 1,456

114 of 1,459

0.6 points

-1.4 to 2.6

2,915NCT04333147

Long-term Safety and Efficacy of GSK3196165 (Otilimab) in the Treatment of Rheumatoid Arthritis (RA)

Acadesine vs Placebo (Normal Saline): serious adverse events327 of 1,442

329 of 1,457

0.1 points

-2.9 to 3.1

2,899NCT00872001

The Effect Of Acadesine On Reducing Cardiovascular and Cerebrovascular Adverse Events In Coronary Artery Bypass Graft (CABG) Surgery (Study P05633 AM1)(TERMINATED)

Low-dose CT vs Standard-dose CT: Diagnostic Confidence in Diagnosing and Ruling Out Appendicitis: Indeterminate Interpretation (Grade 3)34 of 1,459

53 of 1,429

-1.4 points

-2.7 to -0.1

2,888NCT01925014

Low vs. Standard Dose CT for Appendicitis Trial

Palbociclib + Aromatase Inhibitor vs Aromatase Inhibitor: deaths from any cause420 of 1,324

736 of 1,564

-15.3 points

-18.8 to -11.8

2,888NCT05361655

Real-World Effectiveness of Palbociclib in Combination With an Aromatase Inhibitor

Liberal vs Restrictive: Acute Kidney Injury72 of 1,439

124 of 1,443

-3.6 points

-5.4 to -1.8

2,882NCT01424150

REstrictive Versus LIbEral Fluid Therapy in Major Abdominal Surgery: RELIEF Study

Tofacitinib 10 mg vs Tofacitinib 5 mg or 10 mg: Number of Participants With Malignancy Events87 of 2,281

26 of 586

-0.6 points

-2.7 to 1.0

2,867NCT01163253

A Long Term Study To Evaluate The Safety And Tolerability Of CP-690,550 For Patients With Moderate To Severe Chronic Plaque Psoriasis

Tofacitinib 10 mg vs Tofacitinib 5 mg or 10 mg: Number of Participants With Electrocardiogram (ECG) Abnormalities7 of 2,281

2 of 586

-0.0 points

-0.9 to 0.4

2,867NCT01163253

A Long Term Study To Evaluate The Safety And Tolerability Of CP-690,550 For Patients With Moderate To Severe Chronic Plaque Psoriasis

Tofacitinib 10 mg vs Tofacitinib 5 mg or 10 mg: Number of Participants With Adjudicated Cardiovascular Events32 of 2,281

13 of 586

-0.8 points

-2.4 to 0.3

2,867NCT01163253

A Long Term Study To Evaluate The Safety And Tolerability Of CP-690,550 For Patients With Moderate To Severe Chronic Plaque Psoriasis

Tofacitinib 10 mg vs Tofacitinib 5 mg or 10 mg: serious adverse events304 of 2,281

88 of 586

-1.7 points

-5.1 to 1.3

2,867NCT01163253

A Long Term Study To Evaluate The Safety And Tolerability Of CP-690,550 For Patients With Moderate To Severe Chronic Plaque Psoriasis

TICAGRELOR vs CLOPIDOGREL: Participants With Ventricular Pauses of Greater Than or Equal to 3 Seconds in Patients Monitored by Holter 24-hour ECG Recorders for 1 Week Following Randomization84 of 1,451

51 of 1,415

2.2 points

0.6 to 3.8

2,866NCT00391872

A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome

Torsemide vs Furosemide: All-cause Mortality or All-cause Hospitalization, as Measured by Follow-up Phone Call or NDI (for Death)149 of 1,431

157 of 1,428

-0.6 points

-2.9 to 1.7

2,859NCT03296813

TRANSFORM-HF: ToRsemide compArisoN With furoSemide FORManagement of Heart Failure

Request

GET /api/comparisons/v1

Words from a trial's title, conditions or interventions, its outcome or its groups, or an NCT number.

An outcome counted in participants, the serious adverse events, or the deaths from any cause.

No key needed

Code

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curl "https://conductscience.org/api/comparisons/v1?page=130"

Response

The first 2 of this page's 20 results. GET /api/comparisons/v1?page=130

{
  "data": {
    "total": 85013,
    "results": [
      {
        "id": "NCT00072462-sae",
        "title": "Anastrozole vs Tamoxifen: serious adverse events",
        "summary": "333 of 1449 against 371 of 1489; risk difference -1.9 points, 95% interval -5.0 to 1.2; NCT00072462, Adjuvant Tamoxifen Compared With Anastrozole in Treating Postmenopausal Women With Ductal Carcinoma In Situ",
        "record": "/library/comparisons/NCT00072462-sae",
        "nct_id": "NCT00072462",
        "kind": "serious-adverse-events",
        "participants": 2938,
        "risk_difference": {
          "value": -0.01934684581339763,
          "lower": -0.05014735273083506,
          "upper": 0.011537631464459911
        },
        "group_1": "333 of 1,449",
        "group_2": "371 of 1,489",
        "difference": "-1.9 points",
        "interval": "-5.0 to 1.2",
        "trial_title": "Adjuvant Tamoxifen Compared With Anastrozole in Treating Postmenopausal Women With Ductal Carcinoma In Situ"
      },
      {
        "id": "NCT01306331-sae",
        "title": "Conceptrol vs Amphora: serious adverse events",
        "summary": "19 of 1477 against 11 of 1458; risk difference 0.5 points, 95% interval -0.2 to 1.3; NCT01306331, Study of Contraceptive Efficacy & Safety of Phexxi™ (Previously Known as Amphora) Gel Compared to Conceptrol Vaginal Gel",
        "record": "/library/comparisons/NCT01306331-sae",
        "nct_id": "NCT01306331",
        "kind": "serious-adverse-events",
        "participants": 2935,
        "risk_difference": {
          "value": 0.005319331719191295,
          "lower": -0.002181768420619348,
          "upper": 0.013196788038202864
        },
        "group_1": "19 of 1,477",
        "group_2": "11 of 1,458",
        "difference": "0.5 points",
        "interval": "-0.2 to 1.3",
        "trial_title": "Study of Contraceptive Efficacy & Safety of Phexxi™ (Previously Known as Amphora) Gel Compared to Conceptrol Vaginal Gel"
      }
    ],
    "no_events": 33758,
    "columns": [
      {
        "key": "title",
        "label": "Comparison"
      },
      {
        "key": "group_1",
        "label": "With the outcome",
        "under": "group_2"
      },
      {
        "key": "difference",
        "label": "Risk difference, 95% interval",
        "under": "interval"
      },
      {
        "key": "participants",
        "label": "Participants"
      },
      {
        "key": "nct_id",
        "label": "Trial",
        "under": "trial_title"
      }
    ],
    "order": "Most participants first",
    "kinds": {
      "all": 85013,
      "outcome": 33568,
      "serious-adverse-events": 31897,
      "deaths": 19548
    }
  },
  "release": "trial-comparisons-2026-03-23-0.1.0",
  "terms": [
    {
      "source": "ClinicalTrials.gov's posted results, through CTTI's AACT",
      "license": "ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299",
      "notice": "ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.",
      "short": "Freely available. Acknowledgement requested"
    },
    {
      "source": "ClinicalTrials.gov",
      "license": "none stated",
      "notice": "ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.",
      "short": "No license stated"
    }
  ],
  "next": "/api/comparisons/v1?page=131",
  "request_id": "ZKAfLBVu_qLMvdr1"
}

Ask about these results. The first 10 go in the prompt.

About this data
Holds
85,013 comparisons
From ClinicalTrials.gov. Counted 10 Nov 2026.
Release
23 Mar 2026
trial-comparisons-2026-03-23-0.1.0
Checked
20 of 20 review comparisons traced to ClinicalTrials.gov, and all 510,078 numbers calculated again apart from the builder agree
Access
Open
No account. 60 calls a minute from one address.

Sources 2

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.

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Every answer on this page is also JSON, under /api/comparisons/v1. No key.

GET https://conductscience.org/api/comparisons/v1?q=placebo%20heart%20failure&kind=outcome

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  • Which placebo-controlled heart failure trials had the most participants?