Disease · EFO_0003837

calcification

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. calcification. Diseases, record EFO_0003837. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_0003837

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: calcification; Open Targets
Open Targets ID: EFO_0003837; Open Targets
Other names: Bone Mineralization, CALCIFICATION PHYSIOL, CALCIUM DEPOSIT(S), Calcification, Physiologic, Calcification, Physiological, DEPOSIT(S), CALCIUM, Mineralization, Bone, PHYSIOL CALCIFICATION, Physiologic Calcification, Physiological Calcification, calcinosis, macrocalcification, pathologic calcification, pathologically calcified structure; Open Targets
Disease Ontology: DOID:182; Disease Ontology
MeSH: D002113; MeSH
MeSH: D002114; MeSH
NCI Thesaurus: C3672; NCI Thesaurus
Highest stage of its drugs: Phase 2/3, for 1 of its 3 drugs, from ClinicalTrials.gov; Open Targets

Drugs3

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
SODIUM THIOSULFATE	CHEMBL2096650	Small molecule	Phase 2/3	ClinicalTrials.gov	6	6	6	Drugs and targets
TREPROSTINIL	CHEMBL1237119	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
SODIUM METABISULFITE	CHEMBL2016976	Small molecule	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets1

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes
PTGIR	Prostacyclin receptor	1	Prostanoid IP receptor agonist	Phase 2	https://conductscience.org/library/genes/5739

Source Drugs and targets

Trials8

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT03267277	Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis	Phase 2/3	15	2024-02-26	Dermatomyositis, Idiopathic Inflammatory Myopathies	SODIUM THIOSULFATE	Its record names the disease	ClinicalTrials.gov
NCT02663895	Safety and Efficacy of Oral Treprostinil in the Treatment of Calcinosis in Patients With Systemic Sclerosis	Phase 2	12	2021-06-10	Systemic Sclerosis, Calcinosis	TREPROSTINIL	Its record names the disease	ClinicalTrials.gov
NCT01572844	Topical Sodium Thiosulfate and Fractional Carbon Dioxide Laser in Treating Dermatomyositis Associated Calcinosis	Phase 2	3	2017-11-29	Calcinosis	SODIUM THIOSULFATE	Its record names the disease	ClinicalTrials.gov
NCT00720772	Intravenous Sodium Thiosulfate on Coronary Calcification in Patients on Hemodialysis	Phase 2	50		Coronary Calcification, Vascular Calcification	SODIUM THIOSULFATE	Open Targets' reading of its record	ClinicalTrials.gov
NCT03582800	Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot Study	Phase 2	40		Systemic Sclerosis, Dermatomyositis, iPPSD2	SODIUM THIOSULFATE	Its record names the disease	ClinicalTrials.gov
NCT06155578	Safety and Efficacy of Topical Sodium Metabisulfite for the Treatment of Calcinosis in Patients With Systemic Sclerosis	Phase 1/2	20		Systemic Sclerosis, Calcinosis	SODIUM METABISULFITE	Its record names the disease	ClinicalTrials.gov
NCT06672822	Intralesional Injection of STS in Treatment of Calcinosis	Phase 2	20		Systemic Sclerosis (SSc), Dermatomyositis, Mixed Connective Tissue Disease (MCTD), Calcinosis	SODIUM THIOSULFATE	Its record names the disease	ClinicalTrials.gov
NCT01918904	A Pilot Study to Evaluate Topical Sodium Thiosulfate Therapy for Calcinosis Cutis	Phase 2	0		Calcinosis Cutis	SODIUM THIOSULFATE	Open Targets' reading of its record	ClinicalTrials.gov

Comparisons in its trials2

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Treatment Lesion vs No Treatment Lesion: deaths from any cause	0 of 3	0 of 3	6	NCT01572844	Trial comparisons
Treatment Lesion vs No Treatment Lesion: serious adverse events	0 of 3	0 of 3	6	NCT01572844	Trial comparisons

Papers from its trials3

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
22227955	RESULT	1	PubMed
15942915	RESULT	1	PubMed
34718447	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/EFO_0003837

GET https://conductscience.org/api/diseases/v1/EFO_0003837/drugs

API reference For AI assistants