Disease · EFO_0009472
tympanic membrane perforation
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. tympanic membrane perforation. Diseases, record EFO_0009472. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_0009472
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Name
- tympanic membrane perforation
- Open Targets ID
- EFO_0009472
- Highest stage of its drugs
- Phase 2, for 2 of its 5 drugs, from ClinicalTrials.gov
Source Open Targets
Drugs5
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| BASIC FIBROBLAST GROWTH FACTOR (HUMAN) | CHEMBL6068603 | Protein | Phase 2 | ClinicalTrials.gov | 3 | 3 | 3 | Drugs and targets |
| WATER | CHEMBL1098659 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| SODIUM CHLORIDE | CHEMBL1200574 | Small molecule | Phase 1/2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| INSULIN HUMAN | CHEMBL1201631 | Protein | Early phase 1 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| SUCCINAMIDE | CHEMBL541705 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets |
Targets1
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes |
|---|---|---|---|---|---|
| INSR | Insulin receptor | 1 | Insulin receptor agonist | Early phase 1 | https://conductscience.org/library/genes/3643 |
Source Drugs and targets
Trials4
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT02307916 | Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations | Phase 2 | 57 | 2020-06-11 | Tympanic Membrane Perforation | BASIC FIBROBLAST GROWTH FACTOR (HUMAN), WATER | Its record names the disease | ClinicalTrials.gov |
| NCT04960384 | Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations | Phase 2 | 52 | Tympanic Membrane Perforation | BASIC FIBROBLAST GROWTH FACTOR (HUMAN) | Its record names the disease | ClinicalTrials.gov | |
| NCT07535827 | Insulin Intratympanic Application | Early phase 1 | 50 | Tympanic Membrane Perforation | INSULIN HUMAN | Its record names the disease | ClinicalTrials.gov | |
| NCT06448039 | In-office Repair of Chronic Tympanic Membrane Perforations | Phase 1/2 | 20 | Chronic Tympanic Membrane Perforation | BASIC FIBROBLAST GROWTH FACTOR (HUMAN), SODIUM CHLORIDE | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials4
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| FGF-2 vs Placebo: deaths from any cause | 0 of 42 | 0 of 15 | 57 | NCT02307916 | Trial comparisons |
| FGF-2 vs Placebo: serious adverse events | 0 of 42 | 0 of 15 | 57 | NCT02307916 | Trial comparisons |
| FGF-2 vs Placebo: Number of Patients With Normal Mobility of the Eardrum as Assessed by Tympanometry | 23 of 40 | 10 of 14 | 54 | NCT02307916 | Trial comparisons |
| FGF-2 vs Placebo: Number of Patients With Tympanic Membrane Closure Following Treatment | 23 of 40 | 10 of 14 | 54 | NCT02307916 | Trial comparisons |
Papers from its trials0
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
None in this release.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/EFO_0009472
GET https://conductscience.org/api/diseases/v1/EFO_0009472/drugs