Disease · EFO_0009948

chorioamnionitis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. chorioamnionitis. Diseases, record EFO_0009948. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_0009948

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: chorioamnionitis; Open Targets
Open Targets ID: EFO_0009948; Open Targets
Other names: fetal membrane inflammation, inflammation of fetal membrane, intra-amniotic infection; Open Targets
Disease Ontology: DOID:0050697; Disease Ontology
Highest stage of its drugs: Phase 3, for 3 of its 10 drugs, from ClinicalTrials.gov; Open Targets

Drugs10

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
CEFAZOLIN	CHEMBL1435	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
CLARITHROMYCIN	CHEMBL1741	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
ERYTHROMYCIN	CHEMBL532	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
GENTAMICIN	CHEMBL6067485	Small molecule	Phase 2/3	ClinicalTrials.gov	3	3	3	Drugs and targets
AMPICILLIN	CHEMBL174	Small molecule	Phase 2/3	ClinicalTrials.gov	2	2	2	Drugs and targets
SULTAMICILLIN	CHEMBL506110	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
ACETYLCYSTEINE	CHEMBL600	Small molecule	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets
CLINDAMYCIN	CHEMBL1753	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
MISOPROSTOL	CHEMBL606	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
OXYTOCIN	CHEMBL395429	Protein	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets2

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
OXTR	Oxytocin receptor	1	Oxytocin receptor agonist	Unknown	https://conductscience.org/library/genes/5021	Drugs and targets
PTGER3	Prostaglandin E2 receptor EP3 subtype	1	Prostanoid EP3 receptor agonist	Unknown	https://conductscience.org/library/genes/5733	Drugs and targets

Trials6

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02314728	Cervical Ripening in Premature Rupture of Membranes	Not applicable	230	2021-08-10	Pregnancy, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Unfavorable Cervix	MISOPROSTOL, OXYTOCIN	Its record names the disease	ClinicalTrials.gov
NCT00879190	Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis	Phase 2/3	92	2017-03-15	Chorioamnionitis	AMPICILLIN, GENTAMICIN, SULTAMICILLIN	Its record names the disease	ClinicalTrials.gov
NCT00724594	Safety of N-acetylcysteine in Maternal Chorioamnionitis (NAC in Chorio)	Phase 1/2	46	2015-04-30	Chorioamnionitis, Brain Injury	ACETYLCYSTEINE	Its record names the disease	ClinicalTrials.gov
NCT00185991	Comparison of Once Daily Versus 8 Hour Dosing of Gentamicin for the Treatment of Intrapartum Chorioamnionitis	Not applicable	126		Chorioamnionitis	GENTAMICIN	Its record names the disease	ClinicalTrials.gov
NCT01401179	Antibiotics Study in Preterm Premature Rupture of the Membranes	Phase 3	101		Preterm Premature Rupture of the Membranes	CEFAZOLIN, CLARITHROMYCIN, ERYTHROMYCIN	Its record names the disease	ClinicalTrials.gov
NCT00814905	Treatment of Chorioamnionitis After Delivery	Not applicable	0		Chorioamnionitis	AMPICILLIN, CLINDAMYCIN, GENTAMICIN	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials5

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Misoprostol vs Oxytocin Alone: deaths from any cause	0 of 117	0 of 113	230	NCT02314728	Trial comparisons
Misoprostol vs Oxytocin Alone: serious adverse events	0 of 117	0 of 113	230	NCT02314728	Trial comparisons
Unasyn (Ampicillin/Sulbactam) vs Ampicillin/Gentamicin: Composite Maternal Morbidity	0 of 43	6 of 49	92	NCT00879190	Trial comparisons
Unasyn (Ampicillin/Sulbactam) vs Ampicillin/Gentamicin: Treatment Success Defined as Resolution of Fever by 24 Hours Postpartum	43 of 43	49 of 49	92	NCT00879190	Trial comparisons
Unasyn (Ampicillin/Sulbactam) vs Ampicillin/Gentamicin: serious adverse events	0 of 43	0 of 49	92	NCT00879190	Trial comparisons

Papers from its trials15

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
25064164	RESULT	1	PubMed
24297389	RESULT	1	PubMed
22105253	RESULT	1	PubMed
21087166	RESULT	1	PubMed
20093909	RESULT	1	PubMed
16437525	RESULT	1	PubMed
16125041	RESULT	1	PubMed
15802392	RESULT	1	PubMed
10472877	RESULT	1	PubMed
9704771	RESULT	1	PubMed

1 to 10 of 15

See all 15 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/EFO_0009948

GET https://conductscience.org/api/diseases/v1/EFO_0009948/drugs

API reference For AI assistants