Disease · MONDO_0003869

childhood brain stem glioma

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. childhood brain stem glioma. Diseases, record MONDO_0003869. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0003869

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: childhood brain stem glioma; Open Targets
Open Targets ID: MONDO_0003869; Open Targets
Other names: brain stem glioma of childhood, childhood brainstem glioma, childhood glioma of brain stem, childhood glioma of brainstem, childhood glioma of the brain stem, childhood glioma of the brainstem, paediatric brain stem glioma, paediatric brainstem glioma, paediatric glioma of brain stem, paediatric glioma of brainstem, paediatric glioma of the brain stem, paediatric glioma of the brainstem, pediatric brain stem glioma, pediatric brainstem glioma, pediatric glioma of brain stem, pediatric glioma of brainstem, pediatric glioma of the brain stem, pediatric glioma of the brainstem; Open Targets
Disease Ontology: DOID:6383; Disease Ontology
NCI Thesaurus: C9042; NCI Thesaurus
Highest stage of its drugs: Phase 1/2, for 2 of its 2 drugs, from ClinicalTrials.gov; Open Targets

Drugs2

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
TEMOZOLOMIDE	CHEMBL810	Small molecule	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets
VELIPARIB	CHEMBL506871	Small molecule	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets3

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
PARP1	PARP 1, 2 and 3	1	PARP 1, 2 and 3 inhibitor	Phase 1/2	https://conductscience.org/library/genes/142	Drugs and targets
PARP2	PARP 1, 2 and 3	1	PARP 1, 2 and 3 inhibitor	Phase 1/2	https://conductscience.org/library/genes/10038	Drugs and targets
PARP3	PARP 1, 2 and 3	1	PARP 1, 2 and 3 inhibitor	Phase 1/2	https://conductscience.org/library/genes/10039	Drugs and targets

Trials1

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by
NCT01514201	Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas	Phase 1/2	66	2019-08-13	Anaplastic Astrocytoma, Brain Stem Glioma, Childhood Mixed Glioma, Fibrillary Astrocytoma, Giant Cell Glioblastoma, Glioblastoma, Gliosarcoma, Untreated Childhood Anaplastic Astrocytoma, Untreated Childhood Brain Stem Glioma, Untreated Childhood Fibrillary Astrocytoma, Untreated Childhood Giant Cell Glioblastoma, Untreated Childhood Glioblastoma, Untreated Childhood Gliosarcoma	TEMOZOLOMIDE, VELIPARIB	Open Targets' reading of its record

Source ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials2

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
33571520	DERIVED	1	PubMed
32009149	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0003869

GET https://conductscience.org/api/diseases/v1/MONDO_0003869/drugs

API reference For AI assistants