Disease · MONDO_0005441

otitis media

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. otitis media. Diseases, record MONDO_0005441. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005441

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: otitis media; Open Targets
Open Targets ID: MONDO_0005441; Open Targets
Other names: AOM, inflammation of middle ear, medial otitis, middle Ear Inflammation, otitis media (disease); Open Targets
Disease Ontology: DOID:10754; Disease Ontology
MeSH: D010033; MeSH
NCI Thesaurus: C34885; NCI Thesaurus
Highest stage of its drugs: Approval, for 24 of its 30 drugs, from DailyMed, PMDA and TTD; Open Targets

Drugs30

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Source
AMOXICILLIN	CHEMBL1082	Small molecule	Approval	DailyMed	57	Drugs and targets
CLAVULANATE POTASSIUM	CHEMBL1003	Small molecule	Approval	DailyMed	54	Drugs and targets
CEFACLOR	CHEMBL1201018	Small molecule	Approval	DailyMed	11	Drugs and targets
CEFIXIME	CHEMBL1541	Small molecule	Approval	DailyMed	9	Drugs and targets
CEFDINIR	CHEMBL927	Small molecule	Approval	DailyMed	7	Drugs and targets
TRIMETHOPRIM	CHEMBL22	Small molecule	Approval	DailyMed	5	Drugs and targets
CEFUROXIME AXETIL	CHEMBL1095930	Small molecule	Approval	DailyMed	3	Drugs and targets
CEPHALEXIN	CHEMBL1200544	Small molecule	Approval	DailyMed	3	Drugs and targets
CEFTRIAXONE SODIUM	CHEMBL6067656	Small molecule	Approval	DailyMed	2	Drugs and targets
SULFAMETHOXAZOLE	CHEMBL443	Small molecule	Approval	DailyMed	2	Drugs and targets

1 to 10 of 30

See all 30 drugs

Targets3

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
NR3C1	Glucocorticoid receptor	1	Glucocorticoid receptor agonist	Phase 1/2	https://conductscience.org/library/genes/2908	Drugs and targets
TOP2A	DNA topoisomerase II	1	DNA topoisomerase II inhibitor	Phase 1	https://conductscience.org/library/genes/7153	Drugs and targets
TOP2B	DNA topoisomerase II	1	DNA topoisomerase II inhibitor	Phase 1	https://conductscience.org/library/genes/7155	Drugs and targets

Trials4

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02600559	Open-Label Study of OTO-201 in Pediatric Subjects With a History of Otitis Media Requiring Tympanostomy Tubes	Phase 3	501	2020-09-22	Otitis Media	CIPROFLOXACIN	Its record names the disease	ClinicalTrials.gov
NCT02350998	Open-Label Study of OTO-201 for Middle Ear Effusion Evaluating Trans-Tympanostomy Tube Administration	Phase 3	33	2020-09-23	Bilateral Middle Ear Effusion	CIPROFLOXACIN	Its record names the disease	ClinicalTrials.gov
NCT02817347	A Clinical Trial of YH1177 in Patients With Otitis Media and Otorrhea	Phase 1/2	135		Otitis Media, Otorrhea	DEXAMETHASONE, PIPERACILLIN, TAZOBACTAM	Its record names the disease	ClinicalTrials.gov
NCT00781521	Safety and Efficacy of Floxin Otic Solution in the Treatment of Acute Otitis Media in Children	Phase 3	96		Otitis Media	OFLOXACIN	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials0

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

None in this release.

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005441

GET https://conductscience.org/api/diseases/v1/MONDO_0005441/drugs?page=2

API reference For AI assistants