Disease · MONDO_0005620

cerebral amyloid angiopathy

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. cerebral amyloid angiopathy. Diseases, record MONDO_0005620. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005620

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: cerebral amyloid angiopathy; Open Targets
Open Targets ID: MONDO_0005620; Open Targets
Other names: CAA, HCHWA, dutch hereditary cerebral amyloid angiopathy, hereditary cerebral haemorrhage with amyloidosis - Dutch type, hereditary cerebral hemorrhage with amyloidosis - Dutch type; Open Targets
Disease Ontology: DOID:9246; Disease Ontology
MeSH: D016657; MeSH
NCI Thesaurus: C84625; NCI Thesaurus
Orphanet: ORPHA:85458; Orphanet
Highest stage of its drugs: Phase 2, for 2 of its 3 drugs, from ClinicalTrials.gov; Open Targets

Drugs3

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
PONEZUMAB	CHEMBL1743058	Antibody	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
TRAMIPROSATE	CHEMBL149082	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
MINOCYCLINE	CHEMBL1434	Small molecule	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets1

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes
APP	Amyloid-beta precursor protein	2	Amyloid-beta A4 protein binding agent; Amyloid-beta A4 protein stabiliser	Phase 2	https://conductscience.org/library/genes/351

Source Drugs and targets

Trials3

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01821118	Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy	Phase 2	36	2016-11-03	Cerebral Amyloid Angiopathy	PONEZUMAB	Its record names the disease	ClinicalTrials.gov
NCT05680389	Antibiotics Against Amyloid Angiopathy	Phase 1/2	60		Cerebral Amyloid Angiopathy	MINOCYCLINE	Its record names the disease	ClinicalTrials.gov
NCT00056238	Cerebril™ in Patients With Lobar Hemorrhage Related to Cerebral Amyloid Angiopathy	Phase 2	30		Stroke, Neurologic Diseases, General	TRAMIPROSATE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials4

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
PF-04360365 vs Placebo: Number of Participants With Significant Changes From Baseline in Physical Examination at Final Visit	0 of 24	0 of 12	36	NCT01821118	Trial comparisons
PF-04360365 vs Placebo: Number of Participants With Significant Changes in Neurological Examination Results	2 of 24	1 of 12	36	NCT01821118	Trial comparisons
PF-04360365 vs Placebo: Number of Participants With Laboratory Abnormalities	14 of 24	10 of 12	36	NCT01821118	Trial comparisons
PF-04360365 vs Placebo: serious adverse events	2 of 24	2 of 12	36	NCT01821118	Trial comparisons

Papers from its trials1

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it
37277877	DERIVED	1

Source PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005620

GET https://conductscience.org/api/diseases/v1/MONDO_0005620/drugs

API reference For AI assistants