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Disease · MONDO_0011989

leishmaniasis

6 sourcesdiseases-2026-09-18-0.1.0

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ConductScience Library. leishmaniasis. Diseases, record MONDO_0011989. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0011989

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name
leishmaniasis
Open Targets
Open Targets ID
MONDO_0011989
Open Targets
Disease Ontology
DOID:9065
Disease Ontology
MeSH
D007896
MeSH
NCI Thesaurus
C34767
NCI Thesaurus
Orphanet
ORPHA:507
Orphanet
Highest stage of its drugs
Approval, for 12 of its 16 drugs, from ATC and TTD
Open Targets

Drugs16

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

DrugChEMBL IDTypeOpen Targets' stageStage reported byReportsOf them trialsTrials shown hereSource
MILTEFOSINECHEMBL125Small moleculeApprovalATC and TTD422Drugs and targets
ACETARSONECHEMBL1330792Small moleculeApprovalATC100Drugs and targets
BENZNIDAZOLECHEMBL110Small moleculeApprovalATC100Drugs and targets
EFLORNITHINECHEMBL830Small moleculeApprovalATC100Drugs and targets
FEXINIDAZOLECHEMBL1631694Small moleculeApprovalATC100Drugs and targets
MEGLUMINE ANTIMONATECHEMBL239129Small moleculeApprovalATC100Drugs and targets
MELARSOPROLCHEMBL166Small moleculeApprovalATC100Drugs and targets
NIFURTIMOXCHEMBL290960Small moleculeApprovalATC100Drugs and targets
NITROFURAZONECHEMBL869Small moleculeApprovalATC100Drugs and targets
PENTAMIDINE ISETHIONATECHEMBL361506Small moleculeApprovalATC100Drugs and targets

1 to 10 of 16

See all 16 drugs

Targets2

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
FGF1Fibroblast growth factor 11Acidic fibroblast growth factor inhibitorApprovalhttps://conductscience.org/library/genes/2246Drugs and targets
ODC1Ornithine decarboxylase1Ornithine decarboxylase inhibitorApprovalhttps://conductscience.org/library/genes/4953Drugs and targets

Trials4

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

TrialTitlePhaseParticipantsResults first postedConditionsDrugsLinked bySource
NCT01790659Phase 3 Study of Walter Reed (WR) 279,396 and Paromomycin Alone for the Treatment of Cutaneous Leishmaniasis in PanamaPhase 33992017-08-23Cutaneous LeishmaniasisPAROMOMYCINIts record names the diseaseClinicalTrials.gov
NCT06251739Repurposing Ivermectin for PKDL TreatmentEarly phase 130Post-kala-azar Dermal LeishmaniasisIVERMECTIN, MILTEFOSINEOpen Targets' reading of its recordClinicalTrials.gov
NCT02025491Liposomal Amphotericin in Disseminated LeishmaniasisPhase 320Disseminated LeishmaniasisAMPHOTERICIN BOpen Targets' reading, confirmed by NLM's indexing of its papersClinicalTrials.gov
NCT02429505Treatment of Leishmaniasis With Impavido® (Miltefosine): Higher-Weight Patient Registry0LeishmaniasisMILTEFOSINEIts record names the diseaseClinicalTrials.gov

Comparisons in its trials2

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
WR 279,396 vs Paromomycin: deaths from any cause0 of 2010 of 198399NCT01790659Trial comparisons
WR 279,396 vs Paromomycin: serious adverse events2 of 2011 of 198399NCT01790659Trial comparisons

Papers from its trials1

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMIDListed asTrials listing it
26048961DERIVED1

Source PubMed

Data dates

The date of each source this release read.

Open Targets
2026-09-18
Open Targets
Drug links and their checks, from Drugs and targets
2026-09-18
Drugs and targets
ClinicalTrials.gov, from Trials
2026-11-12
Trials
Comparisons, from Trial comparisons
2026-03-23
Trial comparisons
PubMed, for the checks
2026-11-06
PubMed
MeSH, for the checks
2026-11-10
MeSH

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0011989

GET https://conductscience.org/api/diseases/v1/MONDO_0011989/drugs

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