Disease · MONDO_0042491

cervical squamous intraepithelial neoplasia

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. cervical squamous intraepithelial neoplasia. Diseases, record MONDO_0042491. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0042491

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: cervical squamous intraepithelial neoplasia; Open Targets
Open Targets ID: MONDO_0042491; Open Targets
Other names: CIN, cervical sil, cervical squamous intraepithelial lesion, cervix squamous intraepithelial lesion, cervix uteri sil, cervix uteri squamous intraepithelial lesion, squamous intraepithelial lesion of cervix, squamous intraepithelial lesion of cervix uteri, squamous intraepithelial lesion of the cervix, squamous intraepithelial lesion of the cervix uteri, squamous intraepithelial lesion of the uterine cervix, squamous intraepithelial lesion of uterine cervix, uterine cervix sil, uterine cervix squamous intraepithelial lesion; Open Targets
MeSH: D065310; MeSH
NCI Thesaurus: C7346; NCI Thesaurus
Highest stage of its drugs: Early phase 1, for 2 of its 2 drugs, from ClinicalTrials.gov; Open Targets

Drugs2

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
FLUOROURACIL	CHEMBL185	Small molecule	Early phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
IMIQUIMOD	CHEMBL1282	Small molecule	Early phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets2

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
TLR7	Toll-like receptor 7	1	Toll-like receptor 7 agonist	Early phase 1	https://conductscience.org/library/genes/51284	Drugs and targets
TYMS	Thymidylate synthase	1	Thymidylate synthase inhibitor	Early phase 1	https://conductscience.org/library/genes/7298	Drugs and targets

Trials1

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by
NCT03196180	Topical Fluorouracil and Imiquimod in Treating Patients With High-Grade Cervical Intraepithelial Neoplasia	Early phase 1	13	2022-02-23	Cervical Intraepithelial Neoplasia Grade 2/3, Cervical Squamous Cell Carcinoma In Situ, Cervical Squamous Intraepithelial Neoplasia 2, High Grade Cervical Intraepithelial Neoplasia	FLUOROURACIL, IMIQUIMOD	Open Targets' reading of its record

Source ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials0

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

None in this release.

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0042491

GET https://conductscience.org/api/diseases/v1/MONDO_0042491/drugs

API reference For AI assistants