Drug · CHEMBL445
NORTRIPTYLINE
7 sourcespipelines-2026-09-18-0.3.1
Cite this record
ConductScience Library. NORTRIPTYLINE. Drugs and targets, record CHEMBL445. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL445
On this page
Drug
Names and IDs as ChEMBL gives them, through Open Targets.
- Other names
- Desitriptilina, Lumbeck, NCI-169453, NSC-757234, Noramitriptyline, Nortrilen, Nortriptilina, Sesaval
- ChEMBL
Targets2
The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.
| Target | Protein | Mechanism | Action | Gene in Genes |
|---|---|---|---|---|
| SLC6A2 | Sodium-dependent noradrenaline transporter | Norepinephrine transporter inhibitor | INHIBITOR | https://conductscience.org/library/genes/6530 |
| SLC6A4 | Sodium-dependent serotonin transporter | Serotonin transporter inhibitor | INHIBITOR | https://conductscience.org/library/genes/6532 |
Source ChEMBL
Diseases11
The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
1 to 10 of 11Source Open Targets
See all 11 diseasesTrials37
Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 1 more that Open Targets linked to it is not shown, since the release's checks do not confirm it.
| Trial | Title | Phase | Participants | Results first posted | Named as | Linked by | Source |
|---|---|---|---|---|---|---|---|
| NCT02960763 | Optimizing Outcomes of Treatment-Resistant Depression in Older Adults | Phase 4 | 742 | 2022-05-24 | nortriptyline | Its name | ClinicalTrials.gov |
| NCT02260388 | Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations | Phase 4 | 402 | 2018-07-06 | nortriptyline | Its name | ClinicalTrials.gov |
| NCT00539240 | Role of Pain Modulation in GERD Patients Who Failed Standard Dose PPI | Phase 2/3 | 236 | 2014-08-18 | nortriptyline | Its name | ClinicalTrials.gov |
| NCT03844412 | Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments | Phase 2 | 209 | 2026-03-19 | nortriptyline | Its name | ClinicalTrials.gov |
| NCT00066937 | Comparison of Psychological and Pharmacological Treatments for Pain Due to Temporomandibular Joint Disorder (TMD) | Phase 2 | 140 | 2017-07-24 | nortriptyline | Its name | ClinicalTrials.gov |
| NCT00000378 | Antidepressant Treatment of Melancholia in Late Life | Phase 4 | 110 | 2015-04-21 | nortriptyline | Its name | ClinicalTrials.gov |
| NCT02918097 | Cost- Effectiveness and Quality of Life Assessment in Bipolar Disorder Depressive Episode | Phase 4 | 78 | 2020-10-14 | nortriptyline | Its name | ClinicalTrials.gov |
| NCT02901249 | Cost- Effectiveness and Quality of Life Assessment in Major Depression Disorder | Phase 4 | 68 | 2020-10-14 | nortriptyline | Its name | ClinicalTrials.gov |
| NCT00062738 | Treatment of Depression in Parkinson's Disease Trial | Phase 2 | 52 | 2013-03-05 | nortriptyline | Its name | ClinicalTrials.gov |
| NCT00612807 | Treatment of Mood and Marriage Study (TOMMS) | Phase 1/2 | 42 | 2011-04-26 | nortriptyline | Its name | ClinicalTrials.gov |
1 to 10 of 37
See all 37 trialsComparisons in its trials6
Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Sertaline vs Nortriptyline: serious adverse events | 0 of 58 | 0 of 52 | 110 | NCT00000378 | Trial comparisons |
| Semi-weekly Medication Management vs Semi-weekly Medication Management + Weekly Marital Therapy: serious adverse events | 0 of 14 | 0 of 28 | 42 | NCT00612807 | Trial comparisons |
| Experimental vs Control: deaths from any cause | 0 of 4 | 0 of 4 | 8 | NCT04226365 | Trial comparisons |
| Experimental vs Control: serious adverse events | 0 of 4 | 0 of 4 | 8 | NCT04226365 | Trial comparisons |
| Nortriptyline vs Placebo: Question on Whether Patient Has Had Adequate Relief of Abdominal Pain or Discomfort Reported by a Simple Yes or no Answer. | 2 of 3 | 1 of 1 | 4 | NCT00547703 | Trial comparisons |
| Nortriptyline vs Placebo: serious adverse events | 0 of 3 | 0 of 1 | 4 | NCT00547703 | Trial comparisons |
Papers from its trials128
The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Tests in its trials0
The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.
None in this release.
Data dates
The date of each source this release read.
Sources 7
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ConductCognition's list of its testsOur own data
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this drug from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/drugs/v1/CHEMBL445
GET https://conductscience.org/api/drugs/v1/CHEMBL445/trials?page=2