Drug · CHEMBL596

FENTANYL

7 sourcespipelines-2026-09-18-0.3.1

Cite this record

ConductScience Library. FENTANYL. Drugs and targets, record CHEMBL596. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL596

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Drug

Names and IDs as ChEMBL gives them, through Open Targets.

Name: FENTANYL; ChEMBL
ChEMBL ID: CHEMBL596; ChEMBL
Type: Small molecule; ChEMBL
Brand names: Breakyl, Duragesic, Duragesic-100, Duragesic-12, Duragesic-25, Duragesic-37, Duragesic-50, Duragesic-75, Durogesic, Durogesic dtrans, Fencino, Fentalis reservoir, Fentanyl component of tranq, Fentanyl-100, Fentanyl-12, Fentanyl-25, Fentanyl-37, Fentanyl-50, Fentanyl-62, Fentanyl-75, Fentanyl-87, Matrifen, Mezolar matrix, Mylafent, Opiodur, Oralet, Osmach, Osmanil, Recivit, Recuvyra, Subsys, Tilofyl, Victanyl, Yemex; ChEMBL
Other names: AD 923, AD-923, Durogesic d-trans, EN-3267, En3267, Fendrop, Fentanest, Fentanilo, Fentanyl cii, IDS-NF-001, Innovar, N02AB03, Phentanyl, R 4263, Recuvyra, Sublimase; ChEMBL
Other form: FENTANYL CITRATE, CHEMBL688; Drugs and targets
Other form: FENTANYL HYDROCHLORIDE, CHEMBL1201159; Drugs and targets
DrugBank: DB00813; DrugBank
InChIKey: PJMPHNIQZUBGLI-UHFFFAOYSA-N; ChEMBL
Open Targets' highest stage: Approval, for 4 of its 80 diseases, from ATC, DailyMed, EMA Human Drugs, PMDA and TTD; Open Targets

Targets1

The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.

Target	Protein	Mechanism	Action	Gene in Genes
OPRM1	Mu-type opioid receptor	Mu opioid receptor agonist	AGONIST	https://conductscience.org/library/genes/4988

Source ChEMBL

Diseases80

The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Disease	Open Targets' stage	Stage reported by	Reports	Of them trials	Its drugs
Pain	Approval	ATC, DailyMed, EMA Human Drugs and PMDA	102	74	https://conductscience.org/library/drugs?q=HP_0012531
cancer pain	Phase 3	ClinicalTrials.gov and TTD	14	13	https://conductscience.org/library/drugs?q=EFO_0801084
sedation	Phase 3	ClinicalTrials.gov	9	9	https://conductscience.org/library/drugs?q=EFO_0009868
Chronic pain	Approval	DailyMed	40	8	https://conductscience.org/library/drugs?q=HP_0012532
cesarean section	Phase 2/3	ClinicalTrials.gov	5	5	https://conductscience.org/library/drugs?q=EFO_0009636
hypotensive disorder	Phase 2/3	ClinicalTrials.gov	5	5	https://conductscience.org/library/drugs?q=MONDO_0005468
cancer	Approval	DailyMed, EMA Human Drugs and PMDA	9	3	https://conductscience.org/library/drugs?q=MONDO_0004992
Dyspnea	Phase 3	ClinicalTrials.gov	3	3	https://conductscience.org/library/drugs?q=HP_0002094
respiratory depression	Phase 1	ClinicalTrials.gov	3	3	https://conductscience.org/library/drugs?q=EFO_0009842
pain agnosia	Approval	TTD	3	2	https://conductscience.org/library/drugs?q=MONDO_0000675

1 to 10 of 80Source Open Targets

See all 80 diseases

Trials872

Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 2 more that Open Targets linked to it are not shown, since the release's checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Named as	Linked by	Source
NCT02625181	Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis		27,034	2019-03-07	fentanyl	Its name	ClinicalTrials.gov
NCT03726268	Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)	Phase 4	907	2025-11-19	fentanyl	Its name	ClinicalTrials.gov
NCT02937506	Patient Satisfaction With Propofol for Out Patient Colonoscopy	Phase 4	600	2017-09-27	fentanyl	Its name	ClinicalTrials.gov
NCT01809106	RCT Comparing the Analgesic Efficacy of 4 Therapeutic Strategies Based on 4 Different Major Opioids (Fentanyl, Oxycodone, Buprenorphine vs Morphine) in Cancer Patients With Moderate/Severe Pain, at the Moment of Starting 3rd Step of WHO Analgesic Ladder.	Phase 4	518	2015-11-20	fentanyl	Its name	ClinicalTrials.gov
NCT01621230	Effects of Bupivacaine Induced Motor Blockade During the Second Stage of Labor	Phase 4	481	2020-08-24	fentanyl	Its name	ClinicalTrials.gov
NCT01074190	The Effect of Neuraxial Analgesia on Maternal Breastfeeding		345	2022-04-05	fentanyl	Its name	ClinicalTrials.gov
NCT00842829	Study of Breakthrough Cancer Pain: Assessment of Fentanyl Buccal Tablets Titration and Treatment in Opioid-Tolerant Patients	Phase 4	330	2012-09-20	fentanyl	Its name	ClinicalTrials.gov
NCT00463047	Efficacy and Safety of Fentanyl Buccal Tablets Compared With Oxycodone for the Management of Break Through Pain	Phase 3	323	2010-12-14	fentanyl	Its name	ClinicalTrials.gov
NCT00538863	Long-term Safety and Efficacy Study of Fentanyl Sublingual Spray for the Treatment of Breakthrough Cancer Pain	Phase 3	319	2013-10-11	fentanyl	Its name	ClinicalTrials.gov
NCT01488045	Compare Propofol to Fentanyl and Midazolam for Colonoscopy		289	2023-05-23	fentanyl	Its name	ClinicalTrials.gov

1 to 10 of 872

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Comparisons in its trials167

Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Propofol vs Fentanyl Plus Midazolam Only: deaths from any cause	0 of 300	0 of 300	600	NCT02937506	Trial comparisons
Propofol vs Fentanyl Plus Midazolam Only: serious adverse events	0 of 300	0 of 300	600	NCT02937506	Trial comparisons
Fentanyl Buccal Tablets (FBT) vs Immediate-Release Oxycodone: serious adverse events	1 of 281	0 of 284	565	NCT00463047	Trial comparisons
Fentanyl Sublingual Spray Titration vs Fentanyl Sublingual Spray Maintenance: serious adverse events	33 of 229	178 of 269	498	NCT00538863	Trial comparisons
Epidural Fentanyl vs Epidural Bupivacaine Plus Fentanyl (Bupivacaine): Number of Participants Whose Newborns Received an APGAR Score of <=3 at 5 Min	2 of 156	1 of 154	310	NCT01621230	Trial comparisons
Bupivacaine Plus Fentanyl vs Fentanyl Alone: deaths from any cause	0 of 154	0 of 156	310	NCT01621230	Trial comparisons
Epidural Fentanyl vs Epidural Bupivacaine Plus Fentanyl (Bupivacaine): Number of Participants Whose Newborns Received an APGAR Score of <=3 at 1 Min	14 of 156	11 of 154	310	NCT01621230	Trial comparisons
Bupivacaine Plus Fentanyl vs Fentanyl Alone: serious adverse events	0 of 154	0 of 156	310	NCT01621230	Trial comparisons
Ultrasonography vs Palpation: Rate of Successful Obtaining of Free Cerebrospinal Fluid Flow at the First Needle Pass	40 of 140	45 of 140	280	NCT03792191	Trial comparisons
Ultrasonography vs Palpation: Rate of Successful Obtaining of Free Cerebrospinal Fluid Flow at the First Skin Puncture	108 of 140	111 of 140	280	NCT03792191	Trial comparisons

1 to 10 of 167

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Papers from its trials532

The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
40342316	RESULT	1	PubMed
39707278	RESULT	1	PubMed
39193191	RESULT	1	PubMed
38892876	RESULT	1	PubMed
38669011	RESULT	1	PubMed
38666154	RESULT	2	PubMed
38654849	RESULT	1	PubMed
38429736	RESULT	1	PubMed
37990597	RESULT	1	PubMed
37737097	RESULT	1	PubMed

1 to 10 of 532

See all 532 papers from its trials

Tests in its trials3

The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.

Test	Trials naming it as an outcome	As a primary outcome	Source
Remember and Know Test	1	1	ConductCognition
Stroop Color-Word Test	1	1	ConductCognition
Symbol Coding	1	1	ConductCognition

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
ClinicalTrials.gov: 2026-11-05; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
Papers the trials list, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
Tests named in the trials, as ScienceGraph matched them: 2026-11-12; ConductCognition

Sources 7

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ConductCognition's list of its testsOur own data
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this drug from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/drugs/v1/CHEMBL596

GET https://conductscience.org/api/drugs/v1/CHEMBL596/diseases?page=2

API reference For AI assistants