Drug · CHEMBL643
PROMETHAZINE
7 sourcespipelines-2026-09-18-0.3.1
Cite this record
ConductScience Library. PROMETHAZINE. Drugs and targets, record CHEMBL643. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL643
On this page
Drug
Names and IDs as ChEMBL gives them, through Open Targets.
- Other names
- Dimapp, Diphergan, Fargan, NSC-30321, Proazamine, Procit, Prometazin, Prometazina, Protazine, Prothazin, RP-3277, Vallergine
- ChEMBL
Targets1
The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.
| Target | Protein | Mechanism | Action | Gene in Genes |
|---|---|---|---|---|
| HRH1 | Histamine H1 receptor | Histamine H1 receptor antagonist | ANTAGONIST | https://conductscience.org/library/genes/3269 |
Source ChEMBL
Diseases12
The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Disease | Open Targets' stage | Stage reported by | Reports | Of them trials | Its drugs |
|---|---|---|---|---|---|
| Nausea | Approval | TTD | 3 | 2 | https://conductscience.org/library/drugs?q=HP_0002018 |
| Vertigo | Phase 3 | ClinicalTrials.gov | 2 | 2 | https://conductscience.org/library/drugs?q=HP_0002321 |
| aggressive behavior | Phase 3 | ClinicalTrials.gov | 2 | 2 | https://conductscience.org/library/drugs?q=EFO_0003015 |
| Pruritus | Approval | ATC | 2 | 1 | https://conductscience.org/library/drugs?q=HP_0000989 |
| migraine disorder | Phase 3 | ClinicalTrials.gov | 2 | 1 | https://conductscience.org/library/drugs?q=MONDO_0005277 |
| Agitation | Unknown | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=HP_0000713 |
| Pain | Phase 3 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=HP_0012531 |
| Vomiting | Phase 3 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=HP_0002013 |
| gastroparesis | Phase 2 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=MONDO_0006769 |
| motion sickness | Phase 2 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=EFO_0006928 |
1 to 10 of 12Source Open Targets
See all 12 diseasesTrials35
Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs.
| Trial | Title | Phase | Participants | Results first posted | Named as | Linked by | Source |
|---|---|---|---|---|---|---|---|
| NCT02625181 | Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis | 27,034 | 2019-03-07 | promethazine | Its name | ClinicalTrials.gov | |
| NCT00937924 | Adjunct Sedatives in Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP) Procedures | Phase 4 | 304 | 2024-02-26 | promethazine | Its name | ClinicalTrials.gov |
| NCT02473042 | Intraoperative Acupoint Stimulation to Prevent Post-Operative Nausea and Vomiting (PONV) | 188 | 2025-12-05 | promethazine | Its name | ClinicalTrials.gov | |
| NCT00655642 | Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED | 171 | 2011-05-09 | promethazine | Its name | ClinicalTrials.gov | |
| NCT01474915 | Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting | Phase 4 | 122 | 2013-12-03 | promethazine | Its name | ClinicalTrials.gov |
| NCT03639558 | TREC-Lebanon: A Trial for Rapid Tranquilisation for Agitated Patients in the Emergency Setting | Phase 4 | 100 | 2022-06-14 | promethazine | Its name | ClinicalTrials.gov |
| NCT04805073 | Treatment of Pruritus With Intramuscular Promethazine | Phase 4 | 72 | 2025-05-04 | promethazine | Its name | ClinicalTrials.gov |
| NCT02635828 | Effectiveness of Triple Therapy With Palonosetron for PON Prophylaxis | Phase 4 | 40 | 2017-05-05 | promethazine | Its name | ClinicalTrials.gov |
| NCT02136420 | Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels | Phase 4 | 30 | 2018-01-08 | promethazine | Its name | ClinicalTrials.gov |
| NCT00541671 | Prevention of Narcotic-Induced Nausea | 25 | 2014-03-13 | promethazine | Its name | ClinicalTrials.gov |
1 to 10 of 35
See all 35 trialsComparisons in its trials12
Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Intervention vs Control: deaths from any cause | 0 of 86 | 0 of 86 | 172 | NCT02473042 | Trial comparisons |
| Intervention vs Control: serious adverse events | 0 of 86 | 0 of 86 | 172 | NCT02473042 | Trial comparisons |
| Aprepitant vs Ondansetron: serious adverse events | 2 of 60 | 3 of 61 | 121 | NCT01474915 | Trial comparisons |
| Haloperidol + Promethazine + Chlorpromazine vs Haloperidol + Promethazine: Time Noted Where Important Adverse Effects Occurred Post Intervention | 0 of 52 | 0 of 48 | 100 | NCT03639558 | Trial comparisons |
| Haloperidol + Promethazine + Chlorpromazine vs Haloperidol + Promethazine: deaths from any cause | 0 of 52 | 0 of 48 | 100 | NCT03639558 | Trial comparisons |
| Haloperidol + Promethazine + Chlorpromazine vs Haloperidol + Promethazine: serious adverse events | 0 of 52 | 0 of 48 | 100 | NCT03639558 | Trial comparisons |
| Promethazine vs Placebo: deaths from any cause | 0 of 34 | 0 of 33 | 67 | NCT04805073 | Trial comparisons |
| Promethazine vs Placebo: serious adverse events | 0 of 34 | 0 of 33 | 67 | NCT04805073 | Trial comparisons |
| Promethazine vs Placebo: Number of Patients Who Became Nauseated After IV Opiate Administration. | 4 of 13 | 5 of 12 | 25 | NCT00541671 | Trial comparisons |
| Promethazine vs Placebo: serious adverse events | 0 of 13 | 0 of 12 | 25 | NCT00541671 | Trial comparisons |
1 to 10 of 12
See all 12 comparisons in its trialsPapers from its trials43
The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Tests in its trials0
The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.
None in this release.
Data dates
The date of each source this release read.
Sources 7
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ConductCognition's list of its testsOur own data
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this drug from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/drugs/v1/CHEMBL643
GET https://conductscience.org/api/drugs/v1/CHEMBL643/trials?page=2