Drug · CHEMBL72
DESIPRAMINE
7 sourcespipelines-2026-09-18-0.3.1
Cite this record
ConductScience Library. DESIPRAMINE. Drugs and targets, record CHEMBL72. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL72
On this page
Drug
Names and IDs as ChEMBL gives them, through Open Targets.
- Other names
- Desipramina, Imipramine, demethyl-, Monodemethylimipramine, N-desmethylimipramine, Norimipramine
- ChEMBL
Targets1
The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.
| Target | Protein | Mechanism | Action | Gene in Genes |
|---|---|---|---|---|
| SLC6A2 | Sodium-dependent noradrenaline transporter | Norepinephrine transporter inhibitor | INHIBITOR | https://conductscience.org/library/genes/6530 |
Source ChEMBL
Diseases17
The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
1 to 10 of 17Source Open Targets
See all 17 diseasesTrials30
Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs.
| Trial | Title | Phase | Participants | Results first posted | Named as | Linked by | Source |
|---|---|---|---|---|---|---|---|
| NCT01265550 | A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors | Phase 3 | 366 | 2018-02-26 | desipramine | Its name | ClinicalTrials.gov |
| NCT00964886 | Efficacy of Antidepressants in Chronic Back Pain | Phase 2 | 142 | 2016-11-29 | desipramine | Its name | ClinicalTrials.gov |
| NCT00338962 | Naltrexone & SSRI in Alcoholics With Depression/PTSD | Phase 3 | 88 | 2016-02-05 | desipramine | Its name | ClinicalTrials.gov |
| NCT03548454 | Comparing Effectiveness of Duloxetine and Desipramine in Patients With Chronic Pain: A Pragmatic Trial Using Point of Care Randomization | Phase 4 | 86 | 2025-11-06 | desipramine | Its name | ClinicalTrials.gov |
| NCT00166114 | Depression, Epinephrine, and Platelet Function | Phase 4 | 40 | 2015-07-23 | desipramine | Its name | ClinicalTrials.gov |
| NCT00456014 | Pre-Treatment Positron Emission Topography Scanning for Increasing Success in Antidepressant Treatment | 37 | 2017-06-14 | desipramine | Its name | ClinicalTrials.gov | |
| NCT00880594 | Irritable Bowel Syndrome (IBS) Functional Magnetic Resonance Imaging (fMRI) With Desipramine | 18 | 2026-01-22 | desipramine | Its name | ClinicalTrials.gov | |
| NCT02428478 | Effect of Desipramine on Genioglossus Muscle Activity in Healthy Adults Study A | Phase 2 | 17 | 2017-03-30 | desipramine | Its name | ClinicalTrials.gov |
| NCT02436031 | Effect of Desipramine on Upper Airway Collapsibility and Genioglossus Muscle Activity in Patients With Obstructive Sleep Apnea - Study B | Phase 2 | 16 | 2017-03-30 | desipramine | Its name | ClinicalTrials.gov |
| NCT01411085 | Risperidone and Desipramine in Alcohol Use and Schizophrenia | Phase 2 | 12 | 2018-03-23 | desipramine | Its name | ClinicalTrials.gov |
1 to 10 of 30
See all 30 trialsComparisons in its trials7
Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Desipramine vs Duloxetine: Adherence | 18 of 38 | 24 of 48 | 86 | NCT03548454 | Trial comparisons |
| Desipramine vs Duloxetine: Pain Intensity | 11 of 38 | 29 of 48 | 86 | NCT03548454 | Trial comparisons |
| Desipramine vs Duloxetine: deaths from any cause | 0 of 38 | 0 of 48 | 86 | NCT03548454 | Trial comparisons |
| Desipramine vs Duloxetine: serious adverse events | 0 of 38 | 0 of 48 | 86 | NCT03548454 | Trial comparisons |
| Escitalopram vs Desipramine: serious adverse events | 1 of 21 | 0 of 19 | 40 | NCT00166114 | Trial comparisons |
| Desipramine vs Placebo: serious adverse events | 0 of 15 | 0 of 16 | 31 | NCT02428478 | Trial comparisons |
| Desipramine vs Placebo: serious adverse events | 0 of 16 | 0 of 15 | 31 | NCT02436031 | Trial comparisons |
Papers from its trials16
The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Tests in its trials0
The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.
None in this release.
Data dates
The date of each source this release read.
Sources 7
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ConductCognition's list of its testsOur own data
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this drug from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/drugs/v1/CHEMBL72
GET https://conductscience.org/api/drugs/v1/CHEMBL72/trials?page=2