Drug · CHEMBL896
HYDROXYZINE
7 sourcespipelines-2026-09-18-0.3.1
Cite this record
ConductScience Library. HYDROXYZINE. Drugs and targets, record CHEMBL896. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL896
On this page
Drug
Names and IDs as ChEMBL gives them, through Open Targets.
Targets1
The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.
| Target | Protein | Mechanism | Action | Gene in Genes |
|---|---|---|---|---|
| HRH1 | Histamine H1 receptor | Histamine H1 receptor antagonist | ANTAGONIST | https://conductscience.org/library/genes/3269 |
Source ChEMBL
Diseases4
The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Disease | Open Targets' stage | Stage reported by | Reports | Of them trials | Its drugs |
|---|---|---|---|---|---|
| anxiety | Approval | ATC | 3 | 1 | https://conductscience.org/library/drugs?q=MONDO_0011918 |
| Pruritus | Phase 3 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=HP_0000989 |
| myeloproliferative disorder | Phase 3 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=EFO_0004251 |
| anxiety disorder | Approval | TTD | 1 | 0 | https://conductscience.org/library/drugs?q=MONDO_0005618 |
Source Open Targets
Trials22
Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs.
| Trial | Title | Phase | Participants | Results first posted | Named as | Linked by | Source |
|---|---|---|---|---|---|---|---|
| NCT05126459 | A Comparison of Oral Sedation-related Events of Three Multiagent Oral Sedation Regimens in Pediatric Dental Patients | Phase 3 | 60 | 2024-10-02 | hydroxyzine | Its name | ClinicalTrials.gov |
| NCT04068948 | Comparing Pediatric Dental Oral Sedation Outcomes With and Without Meperidine in Children Aged 3-7 Years | Phase 4 | 37 | 2023-12-05 | hydroxyzine | Its name | ClinicalTrials.gov |
| NCT04188106 | Efficacy and Tolerability of Combination Varenicline With Hydroxyzine as a Potential Smoking Cessation Treatment | Phase 4 | 26 | 2023-03-03 | hydroxyzine | Its name | ClinicalTrials.gov |
| NCT00661674 | Palonosetron and Hydroxyzine to Reduce Opioid Withdrawal | 10 | 2017-06-05 | hydroxyzine | Its name | ClinicalTrials.gov | |
| NCT01501591 | Interaction Between Drug and Placebo Effect:Randomized Placebo Controlled Trials May Not be Accurate in Determining Drug Effect Size | 480 | hydroxyzine | Its name | ClinicalTrials.gov | ||
| NCT02374567 | Pharmacovigilance in Gerontopsychiatric Patients | Phase 3 | 407 | hydroxyzine | Its name | ClinicalTrials.gov | |
| NCT01675986 | Comparing the Efficacy of Pregabalin and Hydroxyzine on the Anxiety Score | Phase 2 | 306 | hydroxyzine | Its name | ClinicalTrials.gov | |
| NCT05492812 | Sedation and Nursing Management in EEG Recording in Children | 180 | hydroxyzine | Its name | ClinicalTrials.gov | ||
| NCT03324828 | Presurgery Anxiolysis in Children Treated With Hydroxyzine Versus Non-pharmacological Intervention (Distractoria Technique Clown) | Phase 4 | 170 | hydroxyzine | Its name | ClinicalTrials.gov | |
| NCT01151696 | Pain and Anxiety Management of Traumatic Emergency in a Pre-hospital Setting | Phase 4 | 140 | hydroxyzine | Its name | ClinicalTrials.gov |
1 to 10 of 22
See all 22 trialsComparisons in its trials3
Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Midazolam, Hydroxyzine, Meperidine vs Midazolam, Hydroxyzine: Number of Participants With Successful Sedation | 11 of 20 | 9 of 17 | 37 | NCT04068948 | Trial comparisons |
| Midazolam, Hydroxyzine, Meperidine vs Midazolam, Hydroxyzine: deaths from any cause | 0 of 20 | 0 of 17 | 37 | NCT04068948 | Trial comparisons |
| Midazolam, Hydroxyzine, Meperidine vs Midazolam, Hydroxyzine: serious adverse events | 0 of 20 | 0 of 17 | 37 | NCT04068948 | Trial comparisons |
Papers from its trials6
The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Tests in its trials0
The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.
None in this release.
Data dates
The date of each source this release read.
Sources 7
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ConductCognition's list of its testsOur own data
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this drug from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/drugs/v1/CHEMBL896
GET https://conductscience.org/api/drugs/v1/CHEMBL896/trials?page=2