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Gene · 3039

HBA1: hemoglobin subunit alpha 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HBA1: hemoglobin subunit alpha 1. Genes, record 3039. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3039

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Gene

Symbol
HBA1
HGNC
Name
hemoglobin subunit alpha 1
HGNC
NCBI Gene ID
3039
NCBI Gene
HGNC ID
HGNC:4823
HGNC
Ensembl
ENSG00000206172
NCBI Gene
Aliases
ECYT7, HBA-T3, HBH, METHBA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P69905Hemoglobin subunit alpha142356Ensembl, GeneID, HGNC

Source UniProt

Patents209

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4752548 A12026-06-035P69905Espacenet
JP 2026513230 A2026-04-2351P69905Espacenet
JP 2026004568 A2026-01-1448883P69905Espacenet
JP 2026004568 A2026-01-1448884P69905Espacenet
JP 2026501271 A2026-01-1424P69905Espacenet
KR 1020250166310 A2025-11-2751P69905Espacenet
WO 2025191111 A12025-09-1811P69905Espacenet
US 12297155 B22025-05-131P69905Espacenet
EP 4518890 A22025-03-12112P69905Espacenet
EP 4509607 A22025-02-193P69905Espacenet

1 to 10 of 209

See all 209 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EFAPROXIRALCHEMBL18901Hemoglobin HbA negative modulatorNEGATIVE MODULATORChEMBL
VOXELOTORCHEMBL4101807Hemoglobin HbA positive modulatorPOSITIVE MODULATORChEMBL

Trials27

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06023199VOXELOTORPHASE2ClinicalTrials.gov
NCT05289570VOXELOTORPHASE22024-07-24ClinicalTrials.gov
NCT05228834VOXELOTORPHASE32024-05-02ClinicalTrials.gov
NCT05228821VOXELOTORPHASE4ClinicalTrials.gov
NCT05199766VOXELOTORPHASE2ClinicalTrials.gov
NCT05018728VOXELOTORPHASE2ClinicalTrials.gov
NCT04930445VOXELOTOR2025-12-31ClinicalTrials.gov
NCT04930328VOXELOTORClinicalTrials.gov
NCT04724421VOXELOTORClinicalTrials.gov
NCT04581356VOXELOTORPHASE4ClinicalTrials.gov

1 to 10 of 27

See all 27 trials

NIH grants1,435

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHBA1 papersNewest fiscal year
R01DK103794Systematic Genetic Dissection of Human Erythropoiesis72025
P30CA016042Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
R01HL146500Next generation functional genomics of hematology traits42025
T32HL129982The Genetic Epidemiology of Heart, Lung, and Blood Traits Training Grant (GenHLB)42025
U24HL135600Sickle Africa Data Coordinating Center42025
U54DK106829Stem Cell and Transplantation Biology42025
P20GM109036Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases32025
P30CA008748Cancer Center Support Grant32025
P30CA021765Cancer Center Support Grant (CCSG)32025

1 to 10 of 1,435Source NIH's project files

See all 1,435 nih grants

Papers3,980

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
[Application of Next-Generation Sequencing Technology in Genetic Screening for Thalassemia in Zhangzhou Area].Zhongguo Shi Yan Xue Ye Xue Za Zhi202642802446PubTator, text miningPubMed
Genotype-Specific Hematologic Signatures Across α-Globin Defect Categories in α-Thalassemia.Hemoglobin202642744602PubTator, text miningPubMed
Longstanding Microcytosis with a Thalassaemia-Like Phenotype and Inconclusive Molecular Testing: A Case Report.J Blood Med202642683132PubTator, text miningPubMed
Preanalytical stability of hemoglobin H inclusion body detection using rapid brilliant cresyl blue staining: a genotype-stratified stability study in EDTA blood stored at 4 °C.Lab Med202642673501PubTator, text miningPubMed
Simultaneous detection of thalassemia, hemoglobinopathies, and G6PD variants using long-read nanopore sequencing: genetic complexity and heterogeneity in Thailand.PeerJ202642602612PubTator, text miningPubMed
A Rare Alpha-Globin Mutation: Detailed Analysis of the Hb Rogliano Variant (α1 Cod 108 Thr→Asn).Hemoglobin202642596667PubTator, text miningPubMed
Precision Medicine in Transfusion-Dependent and Non-Transfusion-Dependent β-Thalassemia: Toward Personalized Diagnosis and Therapy.Hemoglobin202642572810PubTator, text miningPubMed
Lifestyle and psychosocial protective factors drive healthy aging and modulate inflammatory and metabolic pathways.Geroscience202642554773PubTator, text miningPubMed
A clinical triage score for MLPA testing in children with microcytosis suspected of deletional alpha-thalassemia.Eur J Pediatr202642554757PubTator, text miningPubMed
Genome-wide methylation profiling identifies signatures of pain, fatigue and health scores in women with systemic lupus erythematosus.Rheumatology (Oxford)202642530360PubTator, text miningPubMed

1 to 10 of 3,980

See all 3,980 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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GET https://conductscience.org/api/genes/v1/3039/patents?page=2