Gene · 3039
HBA1: hemoglobin subunit alpha 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HBA1: hemoglobin subunit alpha 1. Genes, record 3039. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3039
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P69905 | Hemoglobin subunit alpha | 142 | 356 | Ensembl, GeneID, HGNC |
Source UniProt
Patents209
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4752548 A1 | 2026-06-03 | 5 | P69905 | Espacenet |
| JP 2026513230 A | 2026-04-23 | 51 | P69905 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 48883 | P69905 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 48884 | P69905 | Espacenet |
| JP 2026501271 A | 2026-01-14 | 24 | P69905 | Espacenet |
| KR 1020250166310 A | 2025-11-27 | 51 | P69905 | Espacenet |
| WO 2025191111 A1 | 2025-09-18 | 11 | P69905 | Espacenet |
| US 12297155 B2 | 2025-05-13 | 1 | P69905 | Espacenet |
| EP 4518890 A2 | 2025-03-12 | 112 | P69905 | Espacenet |
| EP 4509607 A2 | 2025-02-19 | 3 | P69905 | Espacenet |
1 to 10 of 209
See all 209 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials27
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06023199 | VOXELOTOR | PHASE2 | ClinicalTrials.gov | |
| NCT05289570 | VOXELOTOR | PHASE2 | 2024-07-24 | ClinicalTrials.gov |
| NCT05228834 | VOXELOTOR | PHASE3 | 2024-05-02 | ClinicalTrials.gov |
| NCT05228821 | VOXELOTOR | PHASE4 | ClinicalTrials.gov | |
| NCT05199766 | VOXELOTOR | PHASE2 | ClinicalTrials.gov | |
| NCT05018728 | VOXELOTOR | PHASE2 | ClinicalTrials.gov | |
| NCT04930445 | VOXELOTOR | 2025-12-31 | ClinicalTrials.gov | |
| NCT04930328 | VOXELOTOR | ClinicalTrials.gov | ||
| NCT04724421 | VOXELOTOR | ClinicalTrials.gov | ||
| NCT04581356 | VOXELOTOR | PHASE4 | ClinicalTrials.gov |
1 to 10 of 27
See all 27 trialsNIH grants1,435
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HBA1 papers | Newest fiscal year |
|---|---|---|---|
| R01DK103794 | Systematic Genetic Dissection of Human Erythropoiesis | 7 | 2025 |
| P30CA016042 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| R01HL146500 | Next generation functional genomics of hematology traits | 4 | 2025 |
| T32HL129982 | The Genetic Epidemiology of Heart, Lung, and Blood Traits Training Grant (GenHLB) | 4 | 2025 |
| U24HL135600 | Sickle Africa Data Coordinating Center | 4 | 2025 |
| U54DK106829 | Stem Cell and Transplantation Biology | 4 | 2025 |
| P20GM109036 | Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
1 to 10 of 1,435Source NIH's project files
See all 1,435 nih grantsPapers3,980
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| [Application of Next-Generation Sequencing Technology in Genetic Screening for Thalassemia in Zhangzhou Area]. | Zhongguo Shi Yan Xue Ye Xue Za Zhi | 2026 | 42802446 | PubTator, text mining | PubMed |
| Genotype-Specific Hematologic Signatures Across α-Globin Defect Categories in α-Thalassemia. | Hemoglobin | 2026 | 42744602 | PubTator, text mining | PubMed |
| Longstanding Microcytosis with a Thalassaemia-Like Phenotype and Inconclusive Molecular Testing: A Case Report. | J Blood Med | 2026 | 42683132 | PubTator, text mining | PubMed |
| Preanalytical stability of hemoglobin H inclusion body detection using rapid brilliant cresyl blue staining: a genotype-stratified stability study in EDTA blood stored at 4 °C. | Lab Med | 2026 | 42673501 | PubTator, text mining | PubMed |
| Simultaneous detection of thalassemia, hemoglobinopathies, and G6PD variants using long-read nanopore sequencing: genetic complexity and heterogeneity in Thailand. | PeerJ | 2026 | 42602612 | PubTator, text mining | PubMed |
| A Rare Alpha-Globin Mutation: Detailed Analysis of the Hb Rogliano Variant (α1 Cod 108 Thr→Asn). | Hemoglobin | 2026 | 42596667 | PubTator, text mining | PubMed |
| Precision Medicine in Transfusion-Dependent and Non-Transfusion-Dependent β-Thalassemia: Toward Personalized Diagnosis and Therapy. | Hemoglobin | 2026 | 42572810 | PubTator, text mining | PubMed |
| Lifestyle and psychosocial protective factors drive healthy aging and modulate inflammatory and metabolic pathways. | Geroscience | 2026 | 42554773 | PubTator, text mining | PubMed |
| A clinical triage score for MLPA testing in children with microcytosis suspected of deletional alpha-thalassemia. | Eur J Pediatr | 2026 | 42554757 | PubTator, text mining | PubMed |
| Genome-wide methylation profiling identifies signatures of pain, fatigue and health scores in women with systemic lupus erythematosus. | Rheumatology (Oxford) | 2026 | 42530360 | PubTator, text mining | PubMed |
1 to 10 of 3,980
See all 3,980 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3039
GET https://conductscience.org/api/genes/v1/3039/patents?page=2