Gene · 7036
TFR2: transferrin receptor 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TFR2: transferrin receptor 2. Genes, record 7036. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7036
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UP52 | Transferrin receptor protein 2 | 801 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents58
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 581 | Q9UP52 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 1323 | Q9UP52 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 1325 | Q9UP52 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4652 | Q9UP52 | Espacenet |
| US 12384828 B2 | 2025-08-12 | 204 | Q9UP52 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4652 | Q9UP52 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 581 | Q9UP52 | Espacenet |
| WO 2025024334 A1 | 2025-01-30 | 2 | Q9UP52 | Espacenet |
| US 11878048 B2 | 2024-01-23 | 3 | Q9UP52 | Espacenet |
| JP 2023512562 A | 2023-03-27 | 261 | Q9UP52 | Espacenet |
1 to 10 of 58
See all 58 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials7
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05594992 | PABINAFUSP ALFA | PHASE3 | ClinicalTrials.gov | |
| NCT04573023 | PABINAFUSP ALFA | PHASE3 | ClinicalTrials.gov | |
| NCT04348136 | PABINAFUSP ALFA | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT03708965 | PABINAFUSP ALFA | PHASE2 | ClinicalTrials.gov | |
| NCT03568175 | PABINAFUSP ALFA | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT03359213 | PABINAFUSP ALFA | PHASE2 | ClinicalTrials.gov | |
| NCT00003082 | E2.3 | PHASE1 | ClinicalTrials.gov |
NIH grants784
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TFR2 papers | Newest fiscal year |
|---|---|---|---|
| R01DK095112 | Regulatory Role of Transferrin in Erythropoiesis and Iron Metabolism | 12 | 2025 |
| P30CA062203 | Cancer Center Support Grant | 8 | 2025 |
| P30CA016042 | Cancer Center Support Grant | 3 | 2025 |
| P30CA044579 | University of Virginia Cancer Center Support Grant | 3 | 2025 |
| R01CA148828 | The role of HIF2alpha in colon carcinogenesis | 3 | 2025 |
| R01DK095201 | Control of iron absorption by intestinal HIF2 in iron and hematological disorders | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 2 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 2 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 2 | 2025 |
1 to 10 of 784Source NIH's project files
See all 784 nih grantsPapers1,506
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| CBL0137 inhibits TFR2-mediated IgA1 deposition in IgA nephropathy. | Int Immunopharmacol | 2026 | 42727365 | PubTator, text mining | PubMed |
| Transferrin Promotes Oligodendroglial Differentiation Independently of Iron Binding and Release. | ASN Neuro | 2026 | 42635102 | PubTator, text mining | PubMed |
| Compensated iron depletion in repeated blood donations: Stability of circulating microRNAs despite reduced ferritin stores. | Vox Sang | 2026 | 42574134 | PubTator, text mining | PubMed |
| Fulminant Cardiac Hemochromatosis in a 48-Year-Old African Man With Homozygous TFR2 Variant: A Case Report. | Can J Cardiol | 2026 | 42468617 | PubTator, text mining | PubMed |
| Macrophagic myofasciitis associated with transferrin receptor 2 and solute carrier family 40 member 1 variants and iron dysregulation: a case report. | J Med Case Rep | 2026 | 42436532 | PubTator, text mining | PubMed |
| Shared genetic architecture of schizophrenia and Alzheimer's disease and related dementias implicates 16p11.2 and lifespan brain vulnerability. | Mol Psychiatry | 2026 | 42387103 | PubTator, text mining | PubMed |
| Functional Iron-Transport Genes-TF and TMPRSS6-As Genetic Determinants of Transferrin and Fasting Glucose in a Kazakh Adult Cohort: A Whole-Exome Sequencing Pilot Study. | Int J Mol Sci | 2026 | 42353094 | PubTator, text mining | PubMed |
| Homozygous TFR2 (c.2093_2096del) Mutation in an Asymptomatic Patient With Type 3 Hereditary Hemochromatosis, First Report From Saudi Arabia. | Clin Case Rep | 2026 | 42290821 | PubTator, text mining | PubMed |
| Immunohistochemical investigation of transferrin receptor 2 (TFR2) immunoreactivity in patients with psoriasis vulgaris. | Cutan Ocul Toxicol | 2026 | 42126927 | PubTator, text mining | PubMed |
| Comparing the types of haemochromatosis- from genetics to clinics. | Eur J Hum Genet | 2026 | 41882292 | PubTator, text mining | PubMed |
1 to 10 of 1,506
See all 1,506 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7036
GET https://conductscience.org/api/genes/v1/7036/patents?page=2