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Gene · 7036

TFR2: transferrin receptor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TFR2: transferrin receptor 2. Genes, record 7036. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7036

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Gene

Symbol
TFR2
HGNC
Name
transferrin receptor 2
HGNC
NCBI Gene ID
7036
NCBI Gene
HGNC ID
HGNC:11762
HGNC
Ensembl
ENSG00000106327
NCBI Gene
Aliases
HFE3, TFRC2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UP52Transferrin receptor protein 28010Ensembl, GeneID, HGNC

Source UniProt

Patents58

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19581Q9UP52Espacenet
JP 2025169942 A2025-11-141323Q9UP52Espacenet
JP 2025169942 A2025-11-141325Q9UP52Espacenet
JP 2025529142 A2025-09-044652Q9UP52Espacenet
US 12384828 B22025-08-12204Q9UP52Espacenet
US 12371689 B22025-07-294652Q9UP52Espacenet
JP 2025517970 A2025-06-12581Q9UP52Espacenet
WO 2025024334 A12025-01-302Q9UP52Espacenet
US 11878048 B22024-01-233Q9UP52Espacenet
JP 2023512562 A2023-03-27261Q9UP52Espacenet

1 to 10 of 58

See all 58 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
E2.3CHEMBL2109495Transferrin receptor inhibitorINHIBITORChEMBL
PABINAFUSP ALFACHEMBL4594565Transferrin receptor binding agentBINDING AGENTChEMBL

Trials7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05594992PABINAFUSP ALFAPHASE3ClinicalTrials.gov
NCT04573023PABINAFUSP ALFAPHASE3ClinicalTrials.gov
NCT04348136PABINAFUSP ALFAPHASE2/PHASE3ClinicalTrials.gov
NCT03708965PABINAFUSP ALFAPHASE2ClinicalTrials.gov
NCT03568175PABINAFUSP ALFAPHASE2/PHASE3ClinicalTrials.gov
NCT03359213PABINAFUSP ALFAPHASE2ClinicalTrials.gov
NCT00003082E2.3PHASE1ClinicalTrials.gov

NIH grants784

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTFR2 papersNewest fiscal year
R01DK095112Regulatory Role of Transferrin in Erythropoiesis and Iron Metabolism122025
P30CA062203Cancer Center Support Grant82025
P30CA016042Cancer Center Support Grant32025
P30CA044579University of Virginia Cancer Center Support Grant32025
R01CA148828The role of HIF2alpha in colon carcinogenesis32025
R01DK095201Control of iron absorption by intestinal HIF2 in iron and hematological disorders32025
P30CA008748Cancer Center Support Grant22025
P30CA016056Roswell Park Cancer Center Support Grant22025
P30CA068485Cancer Center Support Grant22025
P30DK063491Diabetes Research Center (DRC)22025

1 to 10 of 784Source NIH's project files

See all 784 nih grants

Papers1,506

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CBL0137 inhibits TFR2-mediated IgA1 deposition in IgA nephropathy.Int Immunopharmacol202642727365PubTator, text miningPubMed
Transferrin Promotes Oligodendroglial Differentiation Independently of Iron Binding and Release.ASN Neuro202642635102PubTator, text miningPubMed
Compensated iron depletion in repeated blood donations: Stability of circulating microRNAs despite reduced ferritin stores.Vox Sang202642574134PubTator, text miningPubMed
Fulminant Cardiac Hemochromatosis in a 48-Year-Old African Man With Homozygous TFR2 Variant: A Case Report.Can J Cardiol202642468617PubTator, text miningPubMed
Macrophagic myofasciitis associated with transferrin receptor 2 and solute carrier family 40 member 1 variants and iron dysregulation: a case report.J Med Case Rep202642436532PubTator, text miningPubMed
Shared genetic architecture of schizophrenia and Alzheimer's disease and related dementias implicates 16p11.2 and lifespan brain vulnerability.Mol Psychiatry202642387103PubTator, text miningPubMed
Functional Iron-Transport Genes-TF and TMPRSS6-As Genetic Determinants of Transferrin and Fasting Glucose in a Kazakh Adult Cohort: A Whole-Exome Sequencing Pilot Study.Int J Mol Sci202642353094PubTator, text miningPubMed
Homozygous TFR2 (c.2093_2096del) Mutation in an Asymptomatic Patient With Type 3 Hereditary Hemochromatosis, First Report From Saudi Arabia.Clin Case Rep202642290821PubTator, text miningPubMed
Immunohistochemical investigation of transferrin receptor 2 (TFR2) immunoreactivity in patients with psoriasis vulgaris.Cutan Ocul Toxicol202642126927PubTator, text miningPubMed
Comparing the types of haemochromatosis- from genetics to clinics.Eur J Hum Genet202641882292PubTator, text miningPubMed

1 to 10 of 1,506

See all 1,506 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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