Gene · 79054
TRPM8: transient receptor potential cation channel subfamily M member 8
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TRPM8: transient receptor potential cation channel subfamily M member 8. Genes, record 79054. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/79054
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q7Z2W7 | Transient receptor potential cation channel subfamily M member 8 | 1,104 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents68
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 67649 | Q7Z2W7 | Espacenet |
| JP 2025172101 A | 2025-11-20 | 1 | Q7Z2W7 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5139 | Q7Z2W7 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5075 | Q7Z2W7 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5075 | Q7Z2W7 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 5139 | Q7Z2W7 | Espacenet |
| EP 4487869 A2 | 2025-01-08 | 483 | Q7Z2W7 | Espacenet |
| JP 2024069452 A | 2024-05-21 | 1 | Q7Z2W7 | Espacenet |
| KR 1020240027895 A | 2024-03-04 | 669 | Q7Z2W7 | Espacenet |
| EP 4268814 A2 | 2023-11-01 | 1 | Q7Z2W7 | Espacenet |
1 to 10 of 68
See all 68 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| D-3263 | CHEMBL3707315 | Transient receptor potential cation channel subfamily M member 8 agonist | AGONIST | ChEMBL |
| ELISMETREP | CHEMBL3682589 | Transient receptor potential cation channel subfamily M member 8 inhibitor | INHIBITOR | ChEMBL |
| MENTHOL | CHEMBL256087 | Transient receptor potential cation channel subfamily M member 8 opener | OPENER | ChEMBL |
Trials17
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07294469 | MENTHOL | PHASE2 | ClinicalTrials.gov | |
| NCT07109609 | MENTHOL | PHASE2 | ClinicalTrials.gov | |
| NCT06848075 | ELISMETREP | PHASE2 | ClinicalTrials.gov | |
| NCT05877079 | MENTHOL | PHASE2 | ClinicalTrials.gov | |
| NCT05799053 | MENTHOL | PHASE3 | ClinicalTrials.gov | |
| NCT04900129 | MENTHOL | PHASE1 | ClinicalTrials.gov | |
| NCT04276727 | MENTHOL | PHASE2 | ClinicalTrials.gov | |
| NCT04103086 | MENTHOL | ClinicalTrials.gov | ||
| NCT03243630 | MENTHOL | EARLY_PHASE1 | 2020-11-13 | ClinicalTrials.gov |
| NCT03095508 | MENTHOL | PHASE3 | 2019-03-21 | ClinicalTrials.gov |
1 to 10 of 17
See all 17 trialsNIH grants1,267
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TRPM8 papers | Newest fiscal year |
|---|---|---|---|
| R01GM093290 | Regulation of the epithelial Ca2+ channels TRPV6 and TRPV5 | 12 | 2025 |
| U54GM104942 | West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health | 7 | 2025 |
| R01CA206573 | Structure and function of Transient Receptor Potential Channels | 6 | 2025 |
| R01NS070711 | Nociceptive Mechanisms Underlying Sickle Cell Pain | 6 | 2025 |
| R35NS105038 | Natural products as probes of the pain pathway | 6 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 6 | 2025 |
| R01NS107253 | Single-Particle Cryo-EM Characterization of AMPA Receptor Functional States | 5 | 2025 |
| R35GM141933 | Molecular Mechanisms and Regulation Networks of TRPM8 | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,267Source NIH's project files
See all 1,267 nih grantsPapers3,190
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Ophthalmic Treatments and Evolving Management of Sjögren's Disease: An Overview. | J Clin Med | 2026 | 42796043 | PubTator, text mining | PubMed |
| Multiscale Modeling of Icilin and Calcium Binding to Human TRPM8 Ion Channel: Insights From MD, MMPBSA, and QM/MM Analyses. | Proteins | 2026 | 42791652 | PubTator, text mining | PubMed |
| Magnetic Nanotransducers as a Universal Platform for Remote Cell Control: Mechanisms, Design, and Therapeutic Potential. | ACS Appl Bio Mater | 2026 | 42779518 | PubTator, text mining | PubMed |
| Therapeutic effects and analgesic mechanisms of iridoid glycosides from Corni Fructus in chronic nonbacterial prostatitis. | J Ethnopharmacol | 2026 | 42772619 | PubTator, text mining | PubMed |
| From Bibliometrics to Preliminary Clinical Evidence: TRP Channel-Mediated Neuroimmune Crosstalk in Temperature-Sensitive Airway Hyperresponsiveness. | J Inflamm Res | 2026 | 42761952 | PubTator, text mining | PubMed |
| TRPM8 virtual screening: the essential role of target-specific, inactive-enriched machine-learning scoring functions. | Digit Discov | 2026 | 42761640 | PubTator, text mining | PubMed |
| Pharmacological Activity of Motugivatrep, a Novel Antagonist of Transient Receptor Potential Cation Channel Subfamily V Member 1. | Biol Pharm Bull | 2026 | 42749621 | PubTator, text mining | PubMed |
| Molecular basis for cold and menthol sensing by mammalian TRPM8. | Nat Commun | 2026 | 42744822 | PubTator, text mining | PubMed |
| Retraction: TRPM8 facilitates proliferation and immune evasion of esophageal cancer cells. | Biosci Rep | 2026 | 42712267 | PubTator, text mining | PubMed |
| Phosgene inhalation injury in mice: Modeling human pathophysiology, biomarker discovery, and therapeutic target identification. | Toxicol Appl Pharmacol | 2026 | 42575345 | PubTator, text mining | PubMed |
1 to 10 of 3,190
See all 3,190 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/79054
GET https://conductscience.org/api/genes/v1/79054/patents?page=2