ConductScience.org, home

Gene · 79054

TRPM8: transient receptor potential cation channel subfamily M member 8

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. TRPM8: transient receptor potential cation channel subfamily M member 8. Genes, record 79054. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/79054

On this page

Gene

Symbol
TRPM8
HGNC
Name
transient receptor potential cation channel subfamily M member 8
HGNC
NCBI Gene ID
79054
NCBI Gene
HGNC ID
HGNC:17961
HGNC
Ensembl
ENSG00000144481
NCBI Gene
Aliases
LTRPC6, LTrpC-6, TRPP8, trp-p8
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q7Z2W7Transient receptor potential cation channel subfamily M member 81,1046Ensembl, GeneID, HGNC

Source UniProt

Patents68

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467649Q7Z2W7Espacenet
JP 2025172101 A2025-11-201Q7Z2W7Espacenet
EP 4641201 A22025-10-295139Q7Z2W7Espacenet
JP 2025529142 A2025-09-045075Q7Z2W7Espacenet
US 12371689 B22025-07-295075Q7Z2W7Espacenet
JP 2025517969 A2025-06-125139Q7Z2W7Espacenet
EP 4487869 A22025-01-08483Q7Z2W7Espacenet
JP 2024069452 A2024-05-211Q7Z2W7Espacenet
KR 1020240027895 A2024-03-04669Q7Z2W7Espacenet
EP 4268814 A22023-11-011Q7Z2W7Espacenet

1 to 10 of 68

See all 68 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
D-3263CHEMBL3707315Transient receptor potential cation channel subfamily M member 8 agonistAGONISTChEMBL
ELISMETREPCHEMBL3682589Transient receptor potential cation channel subfamily M member 8 inhibitorINHIBITORChEMBL
MENTHOLCHEMBL256087Transient receptor potential cation channel subfamily M member 8 openerOPENERChEMBL

Trials17

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

1 to 10 of 17

See all 17 trials

NIH grants1,267

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRPM8 papersNewest fiscal year
R01GM093290Regulation of the epithelial Ca2+ channels TRPV6 and TRPV5122025
U54GM104942West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health72025
R01CA206573Structure and function of Transient Receptor Potential Channels62025
R01NS070711Nociceptive Mechanisms Underlying Sickle Cell Pain62025
R35NS105038Natural products as probes of the pain pathway62025
UL1TR001863Yale Clinical and Translational Science Award62025
R01NS107253Single-Particle Cryo-EM Characterization of AMPA Receptor Functional States52025
R35GM141933Molecular Mechanisms and Regulation Networks of TRPM852025
P30CA068485Cancer Center Support Grant42025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025

1 to 10 of 1,267Source NIH's project files

See all 1,267 nih grants

Papers3,190

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Ophthalmic Treatments and Evolving Management of Sjögren's Disease: An Overview.J Clin Med202642796043PubTator, text miningPubMed
Multiscale Modeling of Icilin and Calcium Binding to Human TRPM8 Ion Channel: Insights From MD, MMPBSA, and QM/MM Analyses.Proteins202642791652PubTator, text miningPubMed
Magnetic Nanotransducers as a Universal Platform for Remote Cell Control: Mechanisms, Design, and Therapeutic Potential.ACS Appl Bio Mater202642779518PubTator, text miningPubMed
Therapeutic effects and analgesic mechanisms of iridoid glycosides from Corni Fructus in chronic nonbacterial prostatitis.J Ethnopharmacol202642772619PubTator, text miningPubMed
From Bibliometrics to Preliminary Clinical Evidence: TRP Channel-Mediated Neuroimmune Crosstalk in Temperature-Sensitive Airway Hyperresponsiveness.J Inflamm Res202642761952PubTator, text miningPubMed
TRPM8 virtual screening: the essential role of target-specific, inactive-enriched machine-learning scoring functions.Digit Discov202642761640PubTator, text miningPubMed
Pharmacological Activity of Motugivatrep, a Novel Antagonist of Transient Receptor Potential Cation Channel Subfamily V Member 1.Biol Pharm Bull202642749621PubTator, text miningPubMed
Molecular basis for cold and menthol sensing by mammalian TRPM8.Nat Commun202642744822PubTator, text miningPubMed
Retraction: TRPM8 facilitates proliferation and immune evasion of esophageal cancer cells.Biosci Rep202642712267PubTator, text miningPubMed
Phosgene inhalation injury in mice: Modeling human pathophysiology, biomarker discovery, and therapeutic target identification.Toxicol Appl Pharmacol202642575345PubTator, text miningPubMed

1 to 10 of 3,190

See all 3,190 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/79054

GET https://conductscience.org/api/genes/v1/79054/patents?page=2