Paper · 10490103

Structural basis for FGF receptor dimerization and activation.

Plotnikov AN and 3 others. Cell, 1999. Cited by 498 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Structural basis for FGF receptor dimerization and activation. Papers, record 10490103. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/10490103

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Structural basis for FGF receptor dimerization and activation.; PubMed
Journal: Cell; PubMed
Year: 1999; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/10490103/; PubMed
DOI: https://doi.org/10.1016/s0092-8674(00)80051-3; PubMed
The journal: https://conductscience.org/library/journal-index/0413066; PubMed
Citations, by iCite: 498; iCite
Relative citation ratio, by iCite: 9.47; iCite
Revised in PubMed: 2022-03-09; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Plotnikov AN	A N
2	Schlessinger J	J
3	Hubbard SR	S R
4	Mohammadi M	M

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Receptor Protein-Tyrosine Kinases	Major topic
Receptors, Fibroblast Growth Factor	Major topic
Amino Acid Sequence
Animals
Crystallography, X-Ray
Dimerization
Fibroblast Growth Factor 2
Heparin
Ligands
Models, Molecular
Molecular Sequence Data
Muscle Proteins
Myosin-Light-Chain Kinase
Peptide Fragments
Peptides
Protein Structure, Tertiary
Receptor, Fibroblast Growth Factor, Type 1
Sequence Homology, Amino Acid

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by196

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 498 citations.

PMID	Title	Journal	Year	In Papers	Source
42,967,007	Change-of-function fibroblast growth factor receptor 3 mutations causing skeletal dysplasias.	J Cell Commun Signal	2026	https://conductscience.org/library/papers/42967007	PubMed
42,681,846	Synthetic Heparan Sulfate-like Oligosaccharides as Tools to Decipher Growth Factor Recognition.	J Med Chem	2026	https://conductscience.org/library/papers/42681846	PubMed
42,559,254	Reprogramming FGFR isoform specificity in FGF2 by deep mutational scanning.	Chem Sci	2026	https://conductscience.org/library/papers/42559254	PubMed
42,429,045	FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review).	Int J Mol Med	2026	https://conductscience.org/library/papers/42429045	PubMed
42,209,519	Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of estrogen receptor-positive breast cancer brain metastases.	Nat Commun	2026	https://conductscience.org/library/papers/42209519	PubMed
41,226,200	Protein-Ligand Interactions in Cardiometabolic Drug Targets: Focus on Weight Loss and Cardioprotection.	Molecules	2025	https://conductscience.org/library/papers/41226200	PubMed
41,155,018	Fibroblast Growth Factor-Derived Peptides: Sources, Functions, and Applications.	Bioengineering (Basel)	2025	https://conductscience.org/library/papers/41155018	PubMed
40,626,957	Developing FGF2 Mutants with Selectively Reduced Heparan Sulfate Affinity to Explore their Impact on FGFR1 Signaling.	Chembiochem	2025	https://conductscience.org/library/papers/40626957	PubMed
40,497,953	FGF-Mediated Axon Guidance: Role of Downstream Signaling Pathways in Cytoskeletal Control.	Cells	2025	https://conductscience.org/library/papers/40497953	PubMed
40,437,501	Reprogramming FGF1 from the natural growth factor to the engineered heparan sulphate biosensor.	Cell Commun Signal	2025	https://conductscience.org/library/papers/40437501	PubMed

1 to 10 of 196

See all 196 cited by

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
FGF2	2,247	PubTator's text mining	https://conductscience.org/library/genes/2247	NCBI Gene
FGFR1	2,260	PubTator's text mining	https://conductscience.org/library/genes/2260	NCBI Gene
MYLK	4,638	PubTator's text mining	https://conductscience.org/library/genes/4638	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bank	Accession
PDB	1CVS

Source PDB

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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