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Paper · 11073996

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

Nakamura N and 5 others. Mol Cell Biol, 2000. Cited by 491 papers, by iCite.

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ConductScience Library. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Papers, record 11073996. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/11073996

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.
PubMed
Journal
Mol Cell Biol
PubMed
Year
2000
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
491
iCite
Relative citation ratio, by iCite
8.36
iCite
Revised in PubMed
2024-11-18
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Nakamura NN
2Ramaswamy SS
3Vazquez FF
4Signoretti SS
5Loda MM
6Sellers WRW R

Source PubMed

Topics22

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cell CycleMajor topic
Cell Cycle ProteinsMajor topic
Cell DeathMajor topic
DNA-Binding ProteinsMajor topic
Genes, Tumor SuppressorMajor topic
Phosphoric Monoester HydrolasesMajor topic
Transcription FactorsMajor topic
Tumor Suppressor ProteinsMajor topic
Biological Transport
Cell Compartmentation
Cell Nucleus
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases
Gene Expression Regulation, Neoplastic
Half-Life
Microtubule-Associated Proteins
PTEN Phosphohydrolase
Phosphorylation
Signal Transduction
Transcription, Genetic
Transcriptional Activation
Tumor Cells, Cultured

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
R01 CA085912NCI NIH HHSUnited StatesR01CA085912PubMed and NIH
R01CA85912NCI NIH HHSUnited StatesR01CA085912PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References75

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
19,072,974PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.Science1997https://conductscience.org/library/papers/9072974PubMed
22,987,699Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation.Nature1985https://conductscience.org/library/papers/2987699PubMed
39,472,0194E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.Genes Dev1998https://conductscience.org/library/papers/9472019PubMed
42,472,450Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily.J Immunol1989https://conductscience.org/library/papers/2472450PubMed
510,358,014Negative regulation of the forkhead transcription factor FKHR by Akt.J Biol Chem1999https://conductscience.org/library/papers/10358014PubMed
610,363,971Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN.Cancer Res1999https://conductscience.org/library/papers/10363971PubMed
77,690,960Production of high-titer helper-free retroviruses by transient transfection.Proc Natl Acad Sci U S A1993https://conductscience.org/library/papers/7690960PubMed
89,778,245Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.Cell1998https://conductscience.org/library/papers/9778245PubMed
99,381,178Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.Science1997https://conductscience.org/library/papers/9381178PubMed
109,593,664The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.J Biol Chem1998https://conductscience.org/library/papers/9593664PubMed

1 to 10 of 75

See all 75 references

Cited by214

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 491 citations.

PMIDTitleJournalYearIn PapersSource
42,012,657
Co-treatment of Colchicine and Rosiglitazone synergistically inhibits cytokine-driven inflammation and modulates the related hsa-miRNA26a-5p, hsa-miRNA21-5p, and STAT3 expression in non-small cell lung cancer.
Naunyn Schmiedebergs Arch Pharmacol2026https://conductscience.org/library/papers/42012657PubMed
41,777,650Pilot study: predicting the interplay between FOXO1 and its downstream long non-coding RNAs in HCC.Front Oncol2026https://conductscience.org/library/papers/41777650PubMed
41,151,860Expression of Glucocorticoid Receptor and FOXO1/phospho-FOXO1 in Bladder Cancer as Independent Prognosticators.Cancer Genomics Proteomics2025https://conductscience.org/library/papers/41151860PubMed
40,046,255Heparin suppresses FoxO1/pFoxO1 signaling axis in vascular smooth muscle cells.Biochem Biophys Rep2025https://conductscience.org/library/papers/40046255PubMed
39,931,984New Advancements in Prognostic Biomarkers for Upper Tract Urothelial Carcinoma.Curr Med Chem2026https://conductscience.org/library/papers/39931984PubMed
39,533,662FoxO1 signaling in B cell malignancies and its therapeutic targeting.FEBS Lett2025https://conductscience.org/library/papers/39533662PubMed
38,191,912O-GlcNAcylation mediates H2O2-induced apoptosis through regulation of STAT3 and FOXO1.Acta Pharmacol Sin2024https://conductscience.org/library/papers/38191912PubMed
38,038,884Epigallocatechin gallate inhibits ovarian cancer cell growth and induces cell apoptosis via activation of FOXO3A.In Vitro Cell Dev Biol Anim2023https://conductscience.org/library/papers/38038884PubMed
37,533,462Synthetic lethal approaches to target cancers with loss of PTEN function.Genes Dis2023https://conductscience.org/library/papers/37533462PubMed
37,174,744The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors.Cells2023https://conductscience.org/library/papers/37174744PubMed

1 to 10 of 214

See all 214 cited by

Genes8

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
CDKN1B1,027PubTator's text mininghttps://conductscience.org/library/genes/1027NCBI Gene
DCTN610,671PubTator's text mininghttps://conductscience.org/library/genes/10671NCBI Gene
FOXO12,308PubTator's text mininghttps://conductscience.org/library/genes/2308NCBI Gene
FOXO32,309PubTator's text mininghttps://conductscience.org/library/genes/2309NCBI Gene
H3P16644,914PubTator's text mininghttps://conductscience.org/library/genes/644914NCBI Gene
PIK3CD5,293PubTator's text mininghttps://conductscience.org/library/genes/5293NCBI Gene
PTEN5,728PubTator's text mininghttps://conductscience.org/library/genes/5728NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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