Paper · 37533462

Synthetic lethal approaches to target cancers with loss of PTEN function.

Ertay A and 2 others. Genes Dis, 2023. Cited by 20 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Synthetic lethal approaches to target cancers with loss of PTEN function. Papers, record 37533462. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/37533462

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Synthetic lethal approaches to target cancers with loss of PTEN function.; PubMed
Journal: Genes Dis; PubMed
Year: 2023; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/37533462/; PubMed
DOI: https://doi.org/10.1016/j.gendis.2022.12.015; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC7614861/; PubMed
The journal: https://conductscience.org/library/journal-index/101635967; PubMed
Citations, by iCite: 20; iCite
Relative citation ratio, by iCite: 2.16; iCite
Revised in PubMed: 2025-05-30; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Ertay A	Ayse
2	Ewing RM	Rob M
3	Wang Y	Yihua

Source PubMed

Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
MR/S025480/1	Medical Research Council	United Kingdom		PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References186

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	9,778,245	Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.	Cell	1998	https://conductscience.org/library/papers/9778245	PubMed
2	9,593,664	The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.	J Biol Chem	1998	https://conductscience.org/library/papers/9593664	PubMed
3	16,107,342	Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta.	J Biol Chem	2005	https://conductscience.org/library/papers/16107342	PubMed
4	28,497,778	PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3.	Nat Commun	2017	https://conductscience.org/library/papers/28497778	PubMed
5	18,794,879	PTEN: a new guardian of the genome.	Oncogene	2008	https://conductscience.org/library/papers/18794879	PubMed
6	25,125,078	PTEN regulates plasma membrane expression of glucose transporter 1 and glucose uptake in thyroid cancer cells.	J Mol Endocrinol	2014	https://conductscience.org/library/papers/25125078	PubMed
7	19,079,342	Id-1 activates Akt-mediated Wnt signaling and p27(Kip1) phosphorylation through PTEN inhibition.	Oncogene	2009	https://conductscience.org/library/papers/19079342	PubMed
8	14,711,368	The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif.	Biochem J	2004	https://conductscience.org/library/papers/14711368	PubMed
9	11,073,996	Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.	Mol Cell Biol	2000	https://conductscience.org/library/papers/11073996	PubMed
10	22,215,152	The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms.	J Mol Med (Berl)	2012	https://conductscience.org/library/papers/22215152	PubMed

1 to 10 of 186

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Cited by12

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 20 citations.

PMID	Title	Journal	Year	In Papers	Source
42,780,483	Targeting the PI3K/Akt Signaling Pathway: A Promising Therapeutic Strategy to Reduce Cancer Mortality and Overcome Chemoresistance.	Health Sci Rep	2026	https://conductscience.org/library/papers/42780483	PubMed
41,492,079	The actionable transcriptome: a framework for incorporating RNA sequencing into precision oncology.	Nat Rev Clin Oncol	2026	https://conductscience.org/library/papers/41492079	PubMed
40,943,615	Current and Emerging Therapies for Targeting the ERK1/2 & PI3K Pathways in Cancer.	Int J Mol Sci	2025	https://conductscience.org/library/papers/40943615	PubMed
40,810,152	Exploring Phosphatase and Tensin Homologue Deleted on Chromosome Ten (PTEN) as a Potential Therapeutic Target for Cardiac Hypertrophy.	ACS Pharmacol Transl Sci	2025	https://conductscience.org/library/papers/40810152	PubMed
40,278,910	CHD1 dysregulation in cancer: bridging chromatin instability, therapy resistance, and immune evasion.	Mol Biol Rep	2025	https://conductscience.org/library/papers/40278910	PubMed
40,240,755	Perspectives on cancer therapy-synthetic lethal precision medicine strategies, molecular mechanisms, therapeutic targets and current technical challenges.	Cell Death Discov	2025	https://conductscience.org/library/papers/40240755	PubMed
40,149,979	Associations Between Follicular Fluid Biomarkers and IVF/ICSI Outcomes in Normo-Ovulatory Women-A Systematic Review.	Biomolecules	2025	https://conductscience.org/library/papers/40149979	PubMed
40,022,037	Identifying high-risk candidates for prolonging progression-free survival in primary gastric carcinoma subject to "double invasion": an analytical approach utilizing lasso-cox regression.	BMC Cancer	2025	https://conductscience.org/library/papers/40022037	PubMed
39,866,010	DNA Damage Repair in Glioblastoma: A Novel Approach to Combat Drug Resistance.	Cell Prolif	2025	https://conductscience.org/library/papers/39866010	PubMed
39,656,422	Role of BRCA1 in glioblastoma etiology.	Cell Oncol (Dordr)	2024	https://conductscience.org/library/papers/39656422	PubMed

1 to 10 of 12

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Genes95

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
ABL1	25	PubTator's text mining	https://conductscience.org/library/genes/25	NCBI Gene
AKT1	207	PubTator's text mining	https://conductscience.org/library/genes/207	NCBI Gene
AKT1S1	84,335	PubTator's text mining	https://conductscience.org/library/genes/84335	NCBI Gene
AKT2	208	PubTator's text mining	https://conductscience.org/library/genes/208	NCBI Gene
AKT3	10,000	PubTator's text mining	https://conductscience.org/library/genes/10000	NCBI Gene
ANXA2	302	PubTator's text mining	https://conductscience.org/library/genes/302	NCBI Gene
APC	324	PubTator's text mining	https://conductscience.org/library/genes/324	NCBI Gene
APEX1	328	PubTator's text mining	https://conductscience.org/library/genes/328	NCBI Gene
ATM	472	PubTator's text mining	https://conductscience.org/library/genes/472	NCBI Gene
ATR	545	PubTator's text mining	https://conductscience.org/library/genes/545	NCBI Gene

1 to 10 of 95

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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